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| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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| Clinical Trials |
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Update of 2005 Cochrane evidence-based review found some evidence in favour of planned management (usually by induction) when women have prelabour rupture of membranes at term. Among twelve trials, one used homoeopathic caulophyllum to induce labor.
Dare 2006
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Update of 2001 Cochrane evidence-based review of homoeopathy for induction of labour found that one trial in which caulophyllum, a commonly used homoeopathic therapy to induce labour, was evaluated may not reflect routine homoeopathy practice.
Smith 2003
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| Observational Studies/Case Reports |
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A 21-y-old female developed tachycardia, diaphoresis, abdominal pain, vomiting and muscle weakness and fasciculations after using blue cohosh (Caulophyllum thalictroides) in an attempt to induce an abortion.
Rao 2002
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[Neonatal effects of maternal consumption of blue cohosh.]
Wright 1999
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[The use of black and blue cohosh in labour.]
Gunn 1996
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| Traditional and Folk Use |
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Monograph in "A Modern Herbal" by Mrs. M. Grieve at
botanical.com
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| Adverse Effects & Toxicity |
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The novel alkaloid thalictroidine, as well as 9 known alkaloids including N-methylcytisine were identified from an extract of C. thalictroides rhizomes. N-Methylcytisine exhibited teratogenic activity in the rat embryo culture (REC), an in vitro method to detect potential teratogens.
Kennelly 1999
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A newborn infant, whose mother took blue cohosh to promote uterine contractions presented with acute myocardial infarction associated with profound congestive heart failure and shock was critically ill for several weeks, eventually recovering
Jones 1998
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| Contraindications |
| No Records |
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| Animal Studies |
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[Proceedings: Observations on the effect of low and high doses of Caulophyllum on the ovaries and the consequential changes in the uterus and thyroid in rats.]
Chandrasekhar 1974
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[Proceedings: Studies on the effect of Caulophyllum on implantation in rats.]
Chandrasekhar 1974
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| Pharmacodynamics |
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[More on blue cohosh and perinatal stroke.]
Chan 2004
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In vitro evaluation of anti-hepatoma activity of 15 natural drugs from Canada including Caulophyllum thalictroides on 5 human liver-cancer cell lines showed that effects of crude drugs on hepatitis B virus genome-containing cell lines were different from those against non hepatitis B virus genomes.
Lin 2002
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[Homeopathic induction. Beyond cimicifuga and caulophyllum.]
Martin 2002
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[Getting to the root of it. A profile of blue cohosh.]
Perri 2002
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Ca2+ channel blockers don't block cauloside induced Ca2+ increase but do inhibit cauloside stimulated proliferation of fibroblasts
Aminin 1999
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Lower pH increases the amount of cauloside C accumulated by tumor cells and changes the pattern of interaction of cauloside C with the membranes
Prokof'eva 1990
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Cauloside C activity at affecting ionic permeability of liposomes is pH dependent. The carbohydrate chain plays an important role
Popov 1982
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Low concentrations of triterpene glycosides: holothurin A, stichoposide A and cauloside C affect the stability of bilayer lipid-sterine membranes
Popov 1982
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Most triterpene glycosides (such as cauloside from Caulophyllum robustum) in low concentrations induced the outflux of K+
Anisimov 1981
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[Effect of triterpene glycosides on 14C-alanine incorporation into rat bone marrow cells].
Prokof'eva 1981
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Leakage of UV-absorbing substances from cells was stimulated by the triterpene glycosides, cauloside, stichoposide and theasaponine. Cauloside maximal effect was at pH 4.8--5.6
Shcheglov 1979
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Cauloside C and theasaponine inhibited ergosterol biosynthesis at the stage of squalene-to-lanosterol transformation by the yeast Saccharomyces carlsbergensis
Anisimov 1978
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Charged amino acides were liberated by cells of Saccharomyces carlsbergensis treated with cauloside, stichoposide and asaponine
Anisimov 1978
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[The antimicrobial activity of the triterpene glycosides of Caulophyllum robustum maxim].
Anisimov 1972
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[A pharmacological study of a crystalline glycoside of Caulophyllum thalictroides.]
FERGUSON 1954
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| Analytical Chemistry |
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An HPLC method has been developed which permits the determination of the triterpene saponins in Caulophyllum thalictroides (blue cohosh) and also the separation of four alkaloids which were detected by evaporative light scattering detection.
Ganzera 2003
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Seven new triterpene saponins were isolated from n-butanol fractions of blue cohosh (Caulophyllum thalictroides) roots and rhizomes. Their structures were established by spectral ((1)H NMR, (13)C NMR, 2D-NMR, and APCI-MS) techniques and chemical reactions.
Jhoo 2001
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Aporphine and quinolizidine alkaloids (methylcystisine, anagyrine, baptifoline, magnoflorine) from Caulophyllum thalictroides root are in the range 0.02-1.1% w/w
Woldemariam 1997
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[Isolation and characterization of alkaloids from Caulophyllum thalictroides.]
Flom 1967
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[The content of therapeutic plants and methods of determination for plant extracts. Comments for an additional edition of the homoepathic pharmacopeia. XIV. XXXVI. Caulophyllum thalictroides. XXXVII. Cepa.] [Article in Undetermined Language]
SCHINDLER 1952
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| Pharmacokinetics (ADME) |
| No Records |
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| Genetics & Molecular Biology |
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| Modern Methods of Preparation |
| No Records |
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| Patents |
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Conduct a search on "Caulophyllum thalictroides" or "blue cohosh" in the title, abstract or claims section of the
US patent database
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Process for co-spray drying liquid herbal extracts with dry silicified MCC.
US patent 7,179,488
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Source of Vitamin B-6 in a nutritional system for nervous system disorders.
US patent 6,399,114
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Female hormonal imbalance mixture comprised of red raspberry, bayberry, blue cohosh, capsicum, cascara sagrada, damiana, ginger, valerian and a binding agent;
US Patent 5,707,630
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| Folk Blends (component) |
| No Records |
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| Contemporary Mixtures (component) |
| No Records |
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| Pictures & Distribution Maps |
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US distribution of Caulophyllum thalictroides at
BONAP
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| Cultivation, Conservation & Ecology |
| No Records |
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| Related Links |
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Monograph from the Australia Naturopathic Network
(ANN)
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Taxonomic information for Caulophyllum at USDA's Germplasm Resources Information Network
(GRIN)
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| HISTORY OF RECORD |
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| RESEARCHED BY: Soaring Bear, Ph.D. December 1999 |
| RESEARCH UPDATED BY: Michael C. Tims, PhD. candidate June 2001 |
| REVISED BY: J Mohanasundaram, MD, PhD March 2006 |
|
