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Animal Studies
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Methanol-water (1:1) extract of Camellia sinensis root at 1/10th of its LD50 dose of100 mg/kg i.p inhibited arachidonic acid-induced paw oedema in rats indicating both cyclooxygenase & lypooxygenase pathways are affected and enhanced peritoneal cell count & macrophages number in normal mice.
Chattopadhyay 2004
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The antioxidant epigallocatechin reduced cuff-induced evolving atherosclerotic plaque size at 21 and 42 days by 55% and 73%, respectively but had no effect on established lesions in the aortic sinuses or the rest of the aorta in the apolipoprotein E-null mice.
Chyu 2004
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The aqueous black tea extract may be effective in preventing bone loss due to ovarian hormone deficiency produced in a bilaterally ovariectomized female albino rat model probably by suppressing rate of bone turnover.
Das 2004
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The protective effects of Thea sinensis melanin (TSM ) in doses 10-40 mg/kg 2 h before intoxication with overdoses of acetaminophen at 400 mg/kg intraperitoneally (i.p.) was studied on ICR mice which revealed that TSM preadministration can prevent the multiple toxic effects of acetaminophen.
Hung 2004
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Among the different concentrations (0.1, 0.2, 0.4, & 0.6%) of green tea solution, only the treatment with 0.6% tea preparation significantly reduced lung tumor multiplicity, inhibited angiogenesis & produced apoptosis index significantly higher in lung adenomas in female A/J mice.
Liao 2004
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Trypanocidal action of catechins of Camellia sinensis against developmental stages of Trypanosoma cruzi is reported and gallocatechin gallate and epigallocatechin gallate lysed more than 50% of the parasites present in the blood of infected BALB/c mice at concentrations as low as 0.12 to 85 pM.
Paveto 2004
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Oral administration of(-)-epigallocatechin 3-gallate (1.0 mg or 1.5 mg/rat) 1 h before challenge with fluorescein isothiocyanate-labeled ovalbumin(FITC-OVA) suppressed neutrophil infiltration into air pouch (inflammatory site) in air-pouch type FITC-OVA-induced allergic inflammation in rats.
Takano 2004
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Black tea extract (Camellia sinensis) was found to possess antidiarrhoeal activity in all the rodent models of diarrhoea tested. Naloxone inhibited the antidiarrhoeal activity of the extract, thus indicating a probable role of opioid mechanism involved.
Besra 2003
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Treatment of rats with theafulvins and theaflavins reduced the apoprotein levels but had no effect on intestinal conjugating enzymes, and treatment with theafulvins led to inhibition of glucuronosyl transferase activity.
Catterall 2003
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Green tea catechin aided in normalizing bone metabolic disorders in bone mineral density, bone mineral content and bone calcium content caused by chronic cadmium intoxication in rats.
Choi 2003
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A review of studies showing consistent findings in animal models of skin, lung, colon, liver and pancreatic cancer that tea and tea polyphenol administration inhibit carcinogen-induced increases in the oxidized DNA base, 8-hydroxy-2'-deoxyguanosine.
Frei 2003
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In vivo and in vitro results suggest that melanin derived from tea confers marked protection of the liver against hydrazine-induced oxidative toxicity.
Hung 2003
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Study on apoptotic fragments assay to investigate radiation response of hair follicles and evaluation of radioprotective agents revealed frequency of radiation (100 cGy)-induced apoptosis in hair follicles of mice was reduced by green tea pretreatment and this model useful for similar studies.
Kim 2003
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The literature on the activity of tea & the tea polyphenols studies in animal models and with cell lines have demonstrated cancer preventive activity, but the epidemiological data remain mixed, probably due to difference in lifestyle, variation in bioavailability and bio-transformation etc.
Lambert 2003c
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Frequent intake of black tea can significantly decrease caries formation in inbred hamsters, even in the presence of sugars in the diet.
Linke 2003
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Study showing polyphenols from green tea inhibited uptake of 3H-dopamine and 1-methyl-4-phenylpyridinium (MPP (+))by DA transporters and partially protected dopaminergic neurons from MPP(+)-induced injury in rats. Suggests GT polyphenols have inhibitory effects on DA transporters.
Pan 2003
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Green tea leaves when fed to rats prior to the exposure of carcinogen prevented the growth of N-butyl-N-(4-hydroxybutyl)-nitrosamine (0.05%) induced urinary bladder tumors suggesting green tea may inhibit tumor initiation in the bladder.
Sato 2003
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Green tea polyphenol may ameliorate renal failure induced by excessive dietary arginine by decreasing uremic toxin, and NO production and increasing radical-scavenging enzyme activity.
Yokozawa 2003
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Polyphenols from C. sinenesis scavenge oxygen radicals and prevent activation of stellate cells.
Zhong 2003
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Gastrointestinal tract factors such as limited membrane permeability, transporter mediated intestinal secretion, or gut wall metabolism may contribute more significantly to the low oral bioavailability of green tea catechins in rats.
Cai 2002
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In animal models of Parkinson's disease the preventive effects of tea containing high levels of (-)-epigallocatechin 3-gallate may be explained by the inhibition of nNOS in the substantia nigra.
Choi 2002
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Melanin from Camellia sinensis is reported for the first time and melanin-gadolinium complex has an LD(50) of 1250-1500 mg/kg in mice and its Magnetic Resonance Imaging properties showed more relaxivity and gastrointestinal enhancement compared to free melanin.
Hung 2002
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Findings provide direct evidence that green tea has a profound inhibitory effect on the intestinal absorption of cholesterol and alphaTP in ovariectomized rats.
Loest 2002
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Topical applications of caffeine or EGCG had a small inhibitory effect on proliferation in nonmalignant tumors and also a similar, but nonsignificant, inhibitory effect on proliferation in malignant tumors.
Lu 2002
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Results suggest red wine and black tea polyphenols modulate COX-2, iNOS and glutathione-related gene expression in tumors, suggesting these compounds may have chemotherapeutic activity.
Luceri 2002
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Kidney function in streptozotocin-induced diabetic rats appears to be improved by green tea catechin due to antithrombotic action, which controls the arachidonic acid cascade system.
Rhee 2002a
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Green tea catechin improves microsomal phospholipase A2 activity and arachidonic acid cascade system in the kidney of diabetic rats, thus improving kidney function.
Rhee 2002b
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Chemopreventive effect of black tea infusion, black tea extract, theaflavin & Epigallocatechin Gallate was exhibited by its inhibition of cell proliferation and induced apoptosis in mice exposed to the chemical carcinogen DMBA by activating four detoxification enzymes viz, GST, GPx, SOD and CAT.
Saha 2002
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Green tea polyphenols inhibit metalloproteinase activities in the skin, muscle, and blood of rainbow trout.
Saito 2002
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Endocrinological changes observed in rats were consistent with antithyroid effects and aromatase inhibition effects of P-60 and its constituents.
Satoh 2002
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Study on chemopreventive efficacy of a black tea infusion on azoxymethane induced colonic preneoplastic lesions and the aberrant crypt foci in Sprague-Dawley rats revealed a reduction in aberrant crypt foci by 44% in the 1% tea-treated and by 40% in 2% tea-treated group.
Sengupta 2002
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Green tea extract is beneficial to rats by reducing lipid peroxidation products and protective to liver, blood serum, and CNS tissues by increasing activity of glutathione peroxidase and glutathione reductase and reducing glutathione, lipid hydroperoxides, 4-hydro-ksynonenal and malondialdehyde.
Skrzydlewska 2002
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Study of cholesterol-fed rats found green tea polyphenol may exert an antiatherosclerotic action by virtue of its antioxidant properties and by increasing HDL cholesterol levels.
Yokozawa 2002
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Rat study suggests green tea extract could be effective in decreasing hepatic injury in disease states where ischemia-reperfusion occurs.
Zhong 2002
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Intake of green tea increases excretion of N-OH-IQ-N-glucuronide, a detoxified metabolite of the proximate carcinogen N-OH-IQ in rats.
Embola 2001
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Review of green tea polyphenols as cancer preventative, identification of genes commonly affected, synergistic or additive effects with cancer preventive agents and effectiveness of daily consumption in preventing cancer.
Fujiki 2001
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Green tea polyphenolic fraction consumption caused significant apoptosis of prostate cancer cells and increased survival of male mice.
Gupta 2001
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Both black tea and its active polyphenols theaflavins and thearubigins have significant anticlastogenic effects in bone marrow cells of mice.
Gupta 2001
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Anti-obesity effects of teasaponin, in high-fat diet-treated mice may be partly mediated through delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
Han 2001
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Green tea might suppress LPS + GalN-induced liver injury through inhibition of TNF-alpha-induced apoptosis of hepatocytes, rather than through suppression of TNF-alpha production in rats.
He 2001
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Dietary supplementation with Japanese green tea extract improved therapeutic effects of antibiotic treatment of levofloxacin against enterohemorrhagic Escherichia coli O157 infection in gnotobiotic mice.
Isogai 2001
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Green tea extract significantly suppressed B[a]P-induced mutation by lowering its specific transversion mutation in lacI transgenic male mice.
Jiang 2001
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Pretreatment with green tea extract or (-)-epigallocatechin-3-gallate prevented dopamine neuron loss, depletion in striatal dopamine and tyrosine hydroxylase protein levels in N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxin treated mice.
Levites 2001
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Treatment of mice with EGCG, from green tea, and dacarbazine combined, strongly inhibited melanoma growth and metastasis by inhibition of cell spreading, cell-extracellular matrix and cell-cell interactions, MMP-9 and FAK activities.
Liu 2001
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Nitric oxide plays a role in hot water extract of black tea -mediated improvement of intestinal motility changes and gastric emptying, induced by diethyl maleate, indoacetamide and N-ethyl maleimide in rats.
Maity 2001
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Chronic ingestion of tea extract prevents development of atherosclerosis without changing plasma lipid level in apoE-deficient mice, probably through potent antioxidative activity.
Miura 2001
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Green tea extract and its individual catechin components were effective in inhibiting breast cancer and endothelial cell proliferation and suppressed xenograft size and decreased the tumor vessel density in mice.
Sartippour 2001
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Thearubigin fraction, from black tea, counteracts the effect of tetanus toxin by binding with toxin, and this fraction may be able to apply for prophylaxis of tetanus.
Satoh 2001
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Tea has a protective effect against BaP-induced genetic damage to germ cells in Swiss albino mice.
Shukla 2001
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Review of literature showing green tea has preventive effects on both chronic inflammatory diseases and lifestyle-related diseases resulting in prolongation of life span.
Sueoka 2001
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Two groups of saponins, TS-1&TS-2, isolated from tea root extract inhibited carrageenan-induced paw oedema in rats and its antioxidant activity was evaluated using the xanthine-xanthine oxidase system.
Sur 2001
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Consumption of black tea (Camellia sinensis) for 2 weeks attenuated development and progression of caries in caries-prone young 18-day-old Sprague-Dawley rats fed with cariogenic diet.
Touyz 2001
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Green tea polyphenols decreased spontaneous interferon-gamma and tumor necrosis factor-alpha secretion and inhibited inflammatory responses in interleukin-2-deficient mice.
Varilek 2001
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Treatment with polysaccharide complex from tea was beneficial for subsequent production of interleukin 2 in spleen cells and also prohibited production of too much IL-1 in adjuvant arthritis rats.
Wang 2001
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Natural antioxidant tea polyphenols had protective effects on repeated mild hypobaric hypoxia induced pulmonary free radical metabolic disorder in mice.
Zhan 2001
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Black tea and wine extracts, but not green tea extracts, can protect against azoxymethane induced colon carcinogenesis by a mechanism probably involving increased apoptosis in tumours.
Caderni 2000
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Tea pigments and tea polyphenols are effective in preventing the occurrence and progression of precancerous liver lesions in rats.
Gong 2000
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Green tea extract minimized eicosanoid accumulation, oxidative damage, and reduced neuronal cell death in experimental ischemia-reperfusion brain injury of Wistar rats.
Hong 2000
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Aqueous black tea extract effectively inhibited the onset of tumorigenesis, cumulative number of tumors and average number of tumors in Swiss albino mice dosed with 7, 12 dimethyl-benzanthracene.
Javed 2000
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Tea catechin oxypolymers can inhibit lipid peroxidation and lipoxygenase effectively, and it also can activate red cell SOD and reduce the MDA content in serum of mice very significantly.
Li 2000
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The effect of 1,2-dimethylhydrazine induced oxidative DNA damage in the colon mucosa of rats is prevented by the consumption of complex polyphenols from black tea.
Lodovici 2000
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Green tea extract reduces cyclooxygenase-2 activity in the colonic mucosa of rats and suppresses the formation of colonic preneoplastic lesions.
Metz 2000
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Saponins from seeds from Camellia sinensis were found to exhibit an inhibitory effect on gastric emptying and an accelerating effect on gastrointestinal transit in mice, with position of acyl groups in the sapogenin moiety showing pharmacological importance.
Murakami 2000
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Liver lipid peroxide levels, plasma alanine transaminase and aspartate transaminase activities were decreased in black tea treated ones compared with CCl4 treated female Wistar rats, however glutathione levels, were not significantly affected, in contrast to the previous data relating to male rats.
Sur-Altiner 2000a
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Liver glutathione & lipid peroxide levels and plasma aspartate transaminase & alanine transaminase activities were significantly decreased in black tea (Camellia sinensis) treated male Wistar rats compared to CCl4 treated group.
Sur-Altiner 2000b
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Four major tea catechins including (-)-epigallocatechin-3-O-gallate and two O-methylated derivatives, (-)-epigallocatechin-3-O-(3-O-methyl)gallate and (-)-epigallocatechin-3-O-(4-O-methyl)gallate, showed inhibitory effects against oxazolone-induced type IV allergy in male ICR mice.
Suzuki 2000
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Chinese green tea lowered plasma cholesterol by increasing fecal bile acids and cholesterol excretion in rats.
Yang 2000
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Acute & chronic administration of black and green tea (Camellia sinensis) extracts significantly accelerated the onset, duration of convulsions and mortality in mice through Ca(2+) channels and not through GABA.
Gomes 1999
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Green tea tannin eliminated oxidative stress and was beneficial to renal function in rats.
Yokozawa 1999
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Antioxidant tea polyphenols had significant protective effects on the hearts of +Gz stressed rats.
Zhan 1999
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Chlorophyll a and b of green tea significantly suppressed, the tumor promotion induced by 12-O-tetradecanoyl-phorbol-13-acetate on BALB/c mouse skin and also reduced TPA-induced inflammatory reaction such as edema formation in BALB/c mouse ear skin.
Higashi-Okai 1998
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Prior administration of hot water black tea extract significantly reduced the incidence of gastric erosions and severity induced by ethanol,diethyldithiocarbamate and diethylmaleate in rats by preventing the reduction in levels of glutathione and glutathione peroxidase caused by them.
Maity 1998
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Sunphenon,a polyphenol compound from leaf of Camellia sinensis, reduced caries incident in S. mutans in infected animals. [Article in Japanese].
Saito 1990
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Pharmacodynamics
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Epigallocatechin gallate, (-)-epigallocatechin,(-)-epicatechin &
caffeine were all delivered transdermally (TD) in polyethylene glycol and citrate-phosphate buffer solutions & adhesive patches containing green tea extract respectively & TD was determined across full thickness pig ear skin.
Batchelder 2004
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Determination of phenolic content, antioxidant capacity and quinone reductase activity of Ardisia compressa (AC) tea in comparison to mate tea and green tea revealed that major polyphenols in AC were not catechins and AC offered protection against cytotoxicity other than by antioxidant effect.
Chandra 2004
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Epigallocatechin gallate, a major constituent of green tea polyphenols, had growth inhibition and cell-cycle arrest effects in NBT-II bladder tumour cells by down-regulating the cyclin D1, cyclin-dependent kinase 4/6 and retinoblastoma protein machinery for regulating cell-cycle progression.
Chen 2004
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Epigallocatechin gallate of Camellia sinensis reduces the Interleukin-1-stimulated expression of both collagenase and stromelysin mRNA species, an effect which may be mediated by inhibition of the JNK/SAPK pathway.
Corps 2004
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Lutein and chlorophyll a and b, the pigments from green tea leaves have potential to protect from dioxin toxicity through suppression of aryl hydrocarbon receptor transformation with 50% inhibitory concentration values against 0.1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Fukuda 2004
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[Unravelling green tea's mechanisms of action: more than meets the eye].
Kaszkin 2004
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3 polymeric black tea polyphenol fractions (PBP-1-3) inhibited microsome-catalyzed [(3)H]-B(a)P-derived DNA adduct formation in vitro in a dose-dependent manner, which is further enhanced on preincubation of microsomes with each of the PBPs.
Krishnan 2004
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Ester bond-containing green tea polyphenols including (-)-epigallocatechin-3-gallate, potently inhibit the proteasomal activity, in intact hepatocellular carcinoma HepG2 and cervical carcinoma HeLa cells, as evident by accumulation of ubiquitinated proteins & 3 natural proteasome targets.
Kuhn 2004
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The inhibitory effect of the crude extracts from 6 herbs including Chinese black tea (Camellia sinensis) on adherence of Streptococcus mutans ATCC 25175 and TPF-1 in vitro revealed that Chinese black tea was the strongest inhibitor.
Limsong 2004
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The green tea extract showed inhibitory effects on both lipoxygenase and hemoglobin -catalyzed oxidation of arachidonic acid and linoleic acid in fish gill. Blood thinning effects were also observed ex vivo by mixing the green tea extract with fish red blood cells.
Liu 2004
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Green tea extract fractions (I-VIII) were more effective against Teladorsagia circumcincta than Trichostrongylus colubriformis larvae as assessed by the larval migration inhibition assay but fractions containing epigallocatechin gallate and proanthocyanidin oligomers were most effective.
Molan 2004
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Numerous studies relate the antioxidant properties of the catechins of epigallocatechin gallate from green tea, with anticancer effects, including the mechanism involving methyl transfers that are subject to allelic variability in the enzyme catechol O-methyl transferase.
Moyers 2004
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Green and black tea inhibited human acetylcholinesterase and human butyrylcholinesterase (IC(50) values of 0.03 mg/mL to 0.06 mg/mL). Green tea also inhibited beta-secretase by 38%. These effects may be relevant to treatment of dementia including Alzheimer's disease.
Okello 2004
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(-)-epicatechin & (+)-catechin derivatives comprised of aromatic groups increased activity and derivatives with acyl chain groups of carbon atoms in close vicinity of C8 - C10 showed strong antimicrobial activity (MIC = 2 - 8 microg/ml) against Gram-positive bacteria and weak activity against fungi.
Park 2004
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Camellia sinensis decreased chromosome damage induced by arsenic to a significant extent, while the addition of ferrous sulphate did not alter the protective action of tea against arsenic in bone marrow cells of laboratory bred Swiss albino mice.
Poddar 2004
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(-) Epigallocatechin gallate, quercetin, gallic acid, green tea, ardisia tea and mate tea extracts were evaluated for their chemopreventive activity using a battery of in vitro marker systems relevant for the prevention of cancer.
Ramirez-Mares 2004
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Green tea in combination with butylated hydroxyanisole increased antimicrobial activity, reduced the hydrophobicity of Streptococcus mutans and greatly inhibited (p<0.001) the formation of hyphae in Candida albicans.
Simonetti 2004
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Modulation of beta-lactam resistance by (-)-epicatechin gallate enhanced activities of flucloxacillin and carbapenem antibiotics imipenem and meropenem against 40 methicillin-resistant Staphylococcus aureus isolates, with MIC(90) values for antibiotics reduced to susceptibility breakpoint or below.
Stapleton 2004
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Tea polyphenols of 0.4microg/mL & 4.0 microg/mL (from either green tea or black tea) down-regulated NADPH oxidase p22phox and p67phox expressions and up-regulated the expressions of catalase which are involved in reactive oxygen species production & elimination in endothelial cells.
Ying 2004
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Epigallocatechin-3-gallate protects against the adverse effects of UV radiation via modulations in NF-kappaB pathway, providing a molecular basis for the photochemopreventive effect.
Afaq 2003
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High antioxidant capacity of some galloylated catechins from tea could be partially due to formation of detergent solubilization resistant membrane structures in which the phospholipids have tightly packed acyl chains and highly hydrated phosphate groups.
Caturla 2003
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Dulbecco's modified Eagle's medium catalyses oxidation of green tea to generate H(2)O(2) which accounted for all of the cytotoxic effects of this beverage on PCl2 cells.
Chai 2003
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Black tea extract supplementation decreased oxidative damage in Jurkat T cells by protecting against ferrous ions induced oxidative damage to DNA and affecting the enzyme antioxidant system.
Erba 2003
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Tea polyphenols, had more anti-oxidative activity than that of alpha-tocopherol.
Hashimoto 2003
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Tea catechins and polyphenols are effective scavengers of reactive oxygen species in vitro and may also function indirectly as antioxidants through their effects on transcription factors and enzyme activities.
Higdon 2003
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Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis.
Hsu 2003a
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Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes.
Hsu 2003b
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Determination of certain mechanisms underlying the differential effects of green tea polyphenols on tumor versus normal cells suggest that green tea polyphenols may simultaneously activate multiple pathways.
Hsu 2003c
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Green tea extract inhibits angiogenesis of human umbilical vein endothelial cells through reduction of expression of VEGF receptors.
Kojima-Yuasa 2003
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Epigallocatechin-3-gallate inhibits mitogen-activated protein kinases, cyclin-dependent kinases, matrix metalloproteinases, growth factor-related cell signaling, activation of activator protein 1 and nuclear factor kappaB, topoisomerase I and matrix metalloproteinases etc in human cancer cell lines.
Lambert 2003b
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Pre-incubation with EGCG concentration-dependently inhibited thrombin-induced aggregation, phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2 of human platelets.
Lill 2003
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(-)-Epigallocatechin gallate may inhibit COMT-catalyzed methylation of endogenous and exogenous compounds.
Lu 2003
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Suppression of ERK phosphorylation by epigallocatechin gallate leads to inhibition of expression for MMP-2 and MMP-9 mRNAs, leading to reduction of enzyme activities of cancer cells.
Maeda-Yamamoto 2003
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Green tea components are capable of reducing the vascularization on CAM that is induced by angiogenin-like protein isolated from goat serum.
Maiti 2003
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Green and black teas markedly to significantly decrease the oxygen radical absorbance capacity in rat liver homogenates, by modulating phase II hepatic drug metabolizing enzymes and oxidative status.
Marnewick 2003
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(-)-epigallocatechin-3-gallate was 10X more effective in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase in cultured HeLa cells when combined with inactive catechins.
Morre 2003
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Among 16 constituents of Scurrula atropurpurea a parasitic plant of the tea plant Thea sinensis, a fatty acid octadeca-8,10,12-triynoic acid exhibits more potent inhibitory effect on cancer cell invasion in vitro than flavanes.
Ohashi 2003
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Green tea epigallocatechin-3-gallate is an inhibitor of mammalian histidine decarboxylase.
Rodriguez-Caso 2003
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The chain-breaking antioxidant activity of teas showed higher mean values for green teas than for oolong and black teas, but differences were not large.
Roginsky 2003
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Black tea has a protective efficacy in suppressing benzo(a)pyrene and cyclophosphamide induced mutagenicity in a microbial test system.
Taneja 2003
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Red wine and green tea potently inhibit VacA, a major virulence factor of Helicobacter pylori.
Tombola 2003
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The enzymes Acatechin gallate esters found in green tea cause selective inhibition of certain members of the aggrecan-degrading activity of 3 mammalian DAMTS-1, -4 and -5 with submicromolar IC50 values.
Vankemmelbeke 2003
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Anti-adenoviral activity of Green tea catechin epigallocatechin-3-gallate uses several mechanisms outside and inside the cell, but at effective drug concentrations well above that reported in the serum of green tea drinkers.
Weber 2003
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Tea polyphenol, (-)-epigallocatechin gallate, is a potential modulator of multidrug-resistance in human carcinoma cells.
Wei 2003
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Modulation of human CYP1A expression by the commercial green tea extract Polyphenon 100 can be attributed to the combination of the four tea catechins and such combination of tea (Camellia senensis) catechins is required for optimal inhibition of induced CYP1A expression.
Williams 2003
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Pathways activated by green tea polyphenols or (-)-epigallocatechin-3-gallate in normal epithelial versus tumor cells create different oxidative environments, favoring either normal cell survival or tumor cell destruction.
Yamamoto 2003
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Higher-concentration green tea ployphenols significantly enhanced the neurotoxicity by treatment of sodium nitroprusside in human neuroblastoma SH-SY5Y cells.
Zhang 2003
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Significant and positive correlations were found between antioxidant capacity and total polyphenol content in a comparative study on the antioxidant capacity of wines and tea and herbal "mate" tea infusions.
Actis-Goretta 2002
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Catechins from green tea were effective at inhibiting proteoglycan and type II collagen breakdown in bovine nasal and metacarpophalangeal cartilage as well as human nondiseased, osteoarthritic and rheumatoid cartilage.
Adcocks 2002
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Green tea polyphenol epigallocatechin-3-gallate causes downregulation of hyperphosphorylated pRb protein that compromises availability of "free" E2F, which leads to stoppage at G1-->S phase transition, causing G0/G1 arrest and apoptotic cell death.
Ahmad 2002
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Results suggest 4-Hydroxynonenal and green tea polyphenol, epigallocatechin-3-gallate, differentially modulate oxidative stress and regulate the growth and survival of astrocytes.
Ahmed 2002
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4-Hydroxynonenal and Green tea polyphenol epigallocatechin-3-gallate differentially modulate oxidative stress and regulate the growth and survival of astrocytes.
Ahmed 2002a
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green tea polyphenol epigallocatechin-3-gallate may afford protection against IL-1 beta-induced production of catabolic mediators NO and PGE(2) in human chondrocytes by regulating the expression and catalytic activity of their respective enzymes.
Ahmed 2002b
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In vitro results suggest an enhancing ("coantimutagenic") effect of selenium in combination with green tea, but in vivo studies are needed.
Amantana 2002
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Tea contains in vitro insulin-enhancing activity and the predominant active ingredient is epigallocatechin gallate.
Anderson 2002
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The green tea polyphenol, (-)-epigallocatechin 3-gallate, acts at both MT1-matrix metalloproteinase gene & protein expression levels in glioblastoma cells and provides a new mechanism for the anticancer properties.
Annabi 2002
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A review showing green tea derivatives as anti-inflammatory, anti-viral and anti-tumor drugs with a focus on inhibitory activity of catechins toward proteases involved in tumor invasion.
Benelli 2002
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The tea polyphenols, (-)-epigallocatechin gallate concentration is 5 times higher in green than in black tea and have greater preventive potential against cancer and cardiovascular diseases. [Article in German].
Bertram 2002
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Green tea polyphenols which bear ortho-dihydroxyl functionality, are good antioxidants for microsomal peroxidation.
Cai 2002
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Tea catechin supplementation may have a role to play in modulating oxidative stress in lead-exposed HepG2 cells.
Chen 2002a
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A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium.
Chen 2002b
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Catechin isolated from tea bush Camellia sinensis, can increase manganese superoxide dismutase gene expression in pheochromocytoma cells (PC-12), and have beneficial effect in tumor prevention.
Chow 2002
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Black tea theafulvins and theaflavins may contribute to anticarcinogenic potential associated with black tea intake.
Dhawan 2002
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Epigallocatechin-3-gallate, component of green tea, strongly inhibited the replication of 2 HIV virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants.
Fassina 2002
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Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures.
Feng 2002
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Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells.
Fujimura 2002
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Green tea (Camellia sinensis) protects against selenite-induced oxidative stress in experimental cataractogenesis.
Gupta 2002
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Green tea catechin (-)-epigallocatechin gallate and other catechol groups are inhibitors that show selectivity for the type 1 isozyme of 5 alpha-reductase.
Hiipakka 2002
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Extracts of green tea made with ethyl ether, which must contain lipophilic components of green tea, inhibited the response elicited by ionotropic gamma-aminobutyric acid.
Hossain 2002a
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The polyphenols (+)-catechin, (-)-epicatechin gallate (ECg), and (-)-epigallocatechin gallate (EGCg), components of green tea, caused an inhibition of the Na(+)/glucose cotransporter response, which was almost independent of glucose concentration.
Hossain 2002b
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Green tea extracts can counteract significant modifications in the fatty acyl pattern induced by doxorubicin in cultured cardiomyocytes.
Hrelia 2002
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The interaction between epigallocatechin gallate and other tea catechins may account for the even stronger ability for green tea polyphenol extract to deactivate ferrylmyoglobin.
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