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| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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Clinical Trials
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A study on the efficacy & safety of a combination of Sabal and Urtica extract (PRO 160/120) in lower urinary tract symptoms-long-term follow-up of a double-blind, multicenter trial of 257 patients revealed that PRO 160/120 increased peak & average urinary flow & decreased residual urine volume.
Lopatkin 2007
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PRO160/120, combined extract of Sabal palm & nettle, in treatment of patients with lower urinary tract symptoms, was superior to placebo by attenuating LUTS assessed by I-PSS, improved obstructive & irritative symptoms, was effective in patients with moderate & severe symptoms. [Article in Russian]
Lopatkin 2006
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A fixed combination of 160 mg sabal fruit extract WS 1473 and 120 mg urtica root extract WS 1031 per capsule is advantageous in obstructive and irritative urinary symptoms and in patients with moderate and severe symptoms caused by benign prostatic hyperplasia.
Lopatkin 2005
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A double-blind placebo-controlled therapeutic study of the combined sabal-urtica preparation PRO 160/120 investigates the changes in the irritative symptoms of benign prostatic hyperplasia (BPH) under the test substance in comparison with placebo. [Article in German]
Popa 2005
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Therapy with Urtica dioica for symptomatic relief of lower urinary tract symptoms secondary to benign prostatic hyperplasia in 620 patients showed beneficial effects.
Safarinejad 2005
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Treatment with Bazoton uno (459 mg dry extract of stinging nettle roots) in 246 patients can be considered a safe therapeutic option for benign prostatic syndrome (BPS), especially for reducing irritative symptoms and BPS-associated complications. [Article in German]
Schneider 2004
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[Long-term efficacy and safety of PRO 160/120 (a combination of sabal and urtica extract) in patients with lower urinary tract symptoms.]
Bondarenko 2003
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The combination of 25mg Pygeum africanum and 300mg stinging nettle extracts produced clinical and urodynamic effects similar to placebo in a group of benign prostatic hyperplasia patients.
Melo 2002
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Randomized controlled trial of nettle sting, for treatment of base-of-thumb pain in 27 patients, reduced both pain and disability, significantly greater than with placebo (P = 0.026 and P = 0.0027).
Randall 2000
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Treatment of 543 patients with benign prostatic hyperplasia, using fixed combination of extracts of saw palmetto fruit and Urtica dioica (PRO 160/120) or finasteride shows that the efficacy of both PRO 160/120 and finasteride was equivalent and unrelated to prostate volume.
Sokeland 2000
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Mouthwash (10 ml, twice a day) with 6.3 mg/ml of Juniperus, Urtica & Achillaea, 1:1:1, has little inhibition of most organisms tested and used twice a day for 3 months had no benefit for gingivitis patients
Van der Weijden 1998
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54 TB patiends getting Urtica, Glycyrrhiza, Tanacetum, Mentha had improvement over the 58 controls
Galitskii 1997
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543 patients in double blind comparison of Sabal+Urtica or finasteride for nearly a year. Results were comparable for urine flow increase and symptom decrease.
Sokeland 1997
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Nettle leaf extract holds down immune reaction cytokines TNF-a and IL-1B in 20 healthy people taking it for 3 weeks. Effect confirmed in vitro.
Teucher 1996
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Sabal extract WS 1473 + Urtica extract WS 1031 improved symptoms for 2080 BPH patients in an open prospective study
Schneider 1995
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Observational Studies/Case Reports
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After assessment of current role of extracts of saw palmetto/urtica in medical management of lower urinary tract symptoms due to benign prostatic enlargement, the American and European Association of Urology has not recommended plant extracts for the management of benign prostatic hyperplasia.
Madersbacher 2008
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A review on risks and benefits of 10 commonly used herbal medicines in Mexico including Urtica dioica revealed that our knowledge of therapeutic benefits and risks of some herbal medicines used in Mexico is still limited and efforts to elucidate them should be intensified.
Rodriguez-Fragoso 2008
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Gynaecomastia in a man and hyper-oestrogenism in a woman attributed to ingestion of nettle (Urtica dioica) as herbal tea in Turkey have been reported.
Sahin 2007
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[General practice study with nettle extract. Arthrosis patient need fewer non-steroidal anti-inflammatory drugs] [Article in German]
[No authors listed] 2002
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Established medications for benign prostatic hyperplasia in current use are alpha-blockers, finasteride, and the phytotherapeutic agents pumpkin seed, nettle root (urticae radix), the phytosterols contained in Hypoxis rooperi, rye pollen & fruits of saw palmetto. [Article in German]
Vahlensieck 2002
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Urtica dioica and Curcubita pepo may be effective when combined with other plant extracts such as Serenoa and Pygeum for the treatment of symptomatic benign prostatic hyperplasia.
Wilt 2000
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An exploratory study of eighteen self-selected patients using the nettle sting of Urtica dioica to treat joint pain suggests that nettle sting is a useful, safe and cheap therapy.
Randall 1999
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Traditional and Folk Use
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A comparative study on wild food plant consumption in twenty-one local communities in Italy showed 11 plant species including Urtica dioica were commonly consumed.
Ghirardini 2007
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Findings from a study of parents of 88 children with cancer undergoing or having received conventional therapy for treatment at a pediatric oncology unit in eastern Turkey shows the most commonly used alternative modality was herbal tea & herbal meal, mostly stinging nettle (Urtica dioica).
Gozum 2007
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An ethnobotanical survey carried out on the territory of the highest mountain in Central Serbia, Kopaonik, shows that among 83 wild species, the wild plants most commonly used for medicinal purposes include Hypericum perforatum & Urtica dioica.
Jaric 2007
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Among 126 traditional medicinal plants from Kirklareli Province in Turkey, the most used plants include Cotinus coggyria, Malva sylvestris, Urtica dioica, Plantago lanceolata, Rosa canina.
Kultur 2007
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Among 128 plants used for ruminant health and diets in British Columbia, Canada, 10 plants including Plantago major, Calendula officinalis, Urtica dioica, are used for diarrhea and scours.
Lans 2007
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In times of scarcity in Poland, several species were used for food: commonly Chenopodium album, Urtica dioica, U.urens, Elymus repens, Oxalis acetosella & Cirsium spp., but now the use of wild plants is mainly restricted to raw consumption or making juices, jams, wines, preservatives.
Luczaj 2007
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Natural treatment of chronic rhinosinusitis includes nutrients and botanicals (ascorbic acid, bromelain, N-acetylcysteine, quercetin, undecylenic acid, and Urtica dioica and other herbal medicines) and procedures (nasal irrigation and naso-sympatico treatments).
Helms 2006
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The most commonly used herbs by diabetic patients in Jordan includes Trigonella foenumgraecum (22.9%), Lupinus albus (14.6%), Allium sativum (11.5%), Zea mays L. (6.3%), Urtica dioica L. (8.3%).
Otoom 2006
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[Benign prostatic syndrome. Urinary urgency and micturition frequency reduced with plant preparation] [Article in German]
[No authors listed] 2005
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Among 71 species used in human therapy in 175 localities of three regions of Central Italy, Malva sylvestris, Urtica dioica, and Sambucus nigra are particularly highly considered.
Guarrera 2005
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[Benign prostate syndrome: urinary tract symptoms can be eased with phytotherapy] [Article in German]
Popa 2005
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Study of traditional medicine in North-West Turkey (Sakarya province) shows that among twenty four of the plant species that were cultivated, the most used plants were Artemisia absinthium, Equisetum telmateia, Lavandula stoechas, Melissa officinalis, Tussilago farfara and Urtica dioica.
Uzun 2004
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Complementary-alternative medicine therapies were used by 41.1% of subjects with cancer after their diagnosis, and the most commonly used herb was stinging nettle leaf (urtica dioica) or seed of nettle. Almost all (93.2%) of the herbs used were nettle.
Gozum 2003
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[Vegetation, vegetables, vesicles: plants and skin.]
Northall 2003
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Serenoa repens, Pygeum africanum, Urtica dioica radix, and Cucurbita peponis semen are some of the botanical therapies used in the treatment of benign prostatic hyperplasia.
Dvorkin 2002
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Botanical diuretics are discussed with a focus on Solidago spp (goldenrod) herb, Levisticum officinale (lovage) root, Petroselinum crispus (parsley) fruit, and Urtica dioica (stinging nettle) herb.
Yarnell 2002
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The use of phytopharmaceuticals for the management of benign prostatic hyperplasia & related lower urinary tract symptoms is common, particularly popular are extracts from the fruits of saw palmetto (Sabal serrulata, syn. Serenoa repens) and roots of stinging nettle (Urtica dioica}.
Koch 2001
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Review on phytotherapeutic agents in the treatment of benign prostatic hyperplasia shows the most commonly used preparations originate from the species Serenoa repens, Pygeum africanum, hypoxis rooperi, pinus, picea, urtica dioica, and secale cereale.
Dreikorn 2000
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Review on natural treatment of perennial allergic rhinitis shows that Urtica dioica, bromelain, quercetin, N-acetylcysteine, and vitamin C are safe, natural therapies that may be used as primary therapy or in conjunction with conventional methods.
Thornhill 2000
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Among 626 hypertensive/diabetic patients, in Morocco, 2/3 use herbal medicine. Urtica dioica is among the most used by hypertension patients
Ziyyat 1997
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Traditional use for rheumatoid arthritis. Urtica dioica leaf extract inhibits 5-lipoxygenase
Obertreis 1996
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Adverse Effects & Toxicity
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The ultrastructural aspect of drug-induced acute urticaria is similar to that observed in urticaria caused by Urtica dioica, intradermal histamine and cold urticaria.
Criado 2006
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The effects of heavy metal pollution on food consumption (Urtica dioica leaves) and reproduction of terrestrial snails under semi-realistic field conditions was investigated which showed that high levels of metal pollution strongly negatively affected reproduction.
Notten 2006
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Immunocytochemical methods confirmed the absence of cross-reactivity between 2 related genera, Parietaria and Urtica, and the lowest allergenic potential of U. dioica.
Vega-Maray 2006
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The frequency of pollen alergy for plants Plantago lanceolata, Chenopodium album, Solidago gigantea, Artemisia vulgaris & Urtica dioica in Sarajevo region for the year 2002 was investigated and 115 patients out of 589 tested were found to be sensitive for pollen alergy. [Article in Bosnian]
Saracevic 2005
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[Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema.]
Caliskaner 2004
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The stinging nettle (Urtica dioica), a common weed can cause a wide range of cutaneous reactions. Contact with the hairs or spines on the stems and leaves of the stinging nettle cause itching, dermatitis, and urticaria within moments of contact.
Anderson 2003
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The uncertainty of the toxic effect of stings from the Urtica species of nettle on hunting dogs particularly in the US is discussed.
Edom 2002
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Urtica agglutinin has short term (2 days) effect of stimulating both CD4+ and CD8+ V beta 8.3+ T cells but they fail to proliferate or to produce IL-2 and are lower than in control mice two months later
Galelli 1995
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15 out of 2080 (0.7%) BPH patients in an open prospective study using Sabal extract WS 1473 + Urtica extract WS 1031 were suspected of having developed mild side effects
Schneider 1995
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Urtica tea has weak activity in inducing genetic change in a sensitive Drosophila fruit fly assay
Graf 1994
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Animal Studies
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A study on effects of Urtica urens L. seed extract on 3-methylcholanthrene (MC) induced cytochrome P450-dependent monooxygenase activities of liver, lungs, and kidneys of rats showed that Urtica supplementation reduced the inducing effects of MC on these cytochrome P450-dependent enzymes.
Ozkarsli 2008
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Effects of the polysaccharide fraction of Urtica fissa (UFP) roots & stems was studied on castrated rat prostate hyperplasia model induced by testosterone propionate which showed that UFP inhibited prostatic hyperplasia & decreased the volume index, wet & dry weight index.
Zhang 2008
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Aqueous (150 mg/kg/day) and to a lesser extent petroleum ether (20 mg/kg/day) extract of Urtica dioica given for 30 days to rats fed with normal or high-fat diet, improved the blood lipid profile.
Daher 2006
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The potential role of Urtica dioica (UD) plant for prevention of oxidative stress in muscle tissues generated by tourniquet application in rats was investigated and the results indicate that UD has a potential antioxidant effect on ischemic muscle tissues.
Cetinus 2005
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Nigella sativa and Urtica dioica decrease the lipid per-oxidation and liver enzymes, and increase the anti-oxidant defense system activity in the CCl4-treated rats.
Kanter 2005
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Mice with chronic dextran sodium sulphate colitis or IL-10-/- mice treated with the stinging nettle leaf extract, clinically and histologically revealed significantly (p < 0.05) fewer signs of colitis than untreated animals.
Konrad 2005
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Immunostimulant effects of dietary intake of medicinal plant extracts including Viscum album, Urtica dioica, & ginger on fish, rainbow trout (Oncorhynchus mykiss), were investigated which revealed that all plant extracts added to fish diet increased total protein level in plasma except 0.1% ginger.
Dugenci 2003
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The active component of Urtica dioica was found to increase the insulin content of blood sera in normal and streptozotocin diabetic rats that were injected intraperitoneally (i.p.) with the active ingredient of the extract.
Farzami 2003
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Nigella sativa L. (NS) and Urtica dioica L. decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in the CCl4-treated rats.
Kanter 2003
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The hypoglycemic activity of lectin isolated from Urtica pilulifera L. seeds (Urticaceae) was investigated in streptozotocin (STZ) induced diabetic rats and hypoglycemic effect was found at the dose of 100 mg/kg after i.p. administration for 30 days.
Kavalali 2003
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Nigella sativa L. and/or Urtica dioica L. treatments might ameliorate the CCl4-induced disturbances of anemia, some minerals, and body's defense mechanism in CCl4-treated rats.
Meral 2003
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The effects of two doses of an ethanol-water (80%-20%) extract of Urtica dioica L. and butylated hydroxyanisole were investigated, for phase I and phase II enzymes, antioxidant enzymes, lactate dehydrogenase, lipid peroxidation and sulfhydryl groups in the liver of Swiss albino mice.
Ozen 2003
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Changes in the concentration of glutathione S-transferases (GSTs) and malondialdehyde (MDA) were assessed in the liver of normal and diabetic NOD mice with and without treatment with the plant extract P-9801091 which contain 10 plants including Urtica dioica L.
Petlevski 2003
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Nigella sativa L. (Ranunculaceae) and Urtica dioica L. seem to be significantly effective in the prevention of carbon tetrachloride induced hepatotoxicity in rats.
Turkdogan 2003
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10 Antidiabetic herbal preparations including Urtica dioica as ethanol extract (extract 1)& ethanol extract from which ethanol was evaporated on a rotatory evaporator at 45 degreesC (extract 2)were investigated in NOD mice & results showed extract 2 decreased the level of glucose & fructosamine.
Petlevski 2001
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An acute hypotensive action of Urtica dioica indicates a direct effect on the cardiovascular system. Moreover, diuretic and natriuretic effects were also observed, suggesting an action on the renal function of rats.
Tahri 2000
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20% methanol extract of Urtica root inhibits induced prostate growth in mice by 51.4%
Lichius 1997
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UDA has short term (2 days) effect of stimulating both CD4+ and CD8+ V beta 8.3+ T cells which fail to proliferate or to produce IL-2 and are lower than in control mice two months later
Galelli 1995
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Pharmacodynamics
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In vitro nematicidal effects of 7 medicinal plants including Urtica dioica from the Sierra de Huautla, Biosphere Reserve, Morelos, Mexico were evaluated against Haemonchus contortus infective larvae in 24-well cell culture plates.
L?-Aroche 2008
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When 22 aqueous extracts from 17 Turkish plants were screened for antibacterial activity on six bacteria, Urtica dioica leaves & three other extracts gave the best inhibitory activity against Strep. pyogenes, Staph. aureus & Staph. epidermidis. Of th 22 extracts, 20 extracts displayed toxicity.
Turker 2008
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A study on the protective effects of two traditionally consumed Turkish medicinal plants, Camellia sinensis and Urtica dioica L., beverages used against chemical carcinogen trichloroacetic acid (TCA)-exposure in rats revealed a significant protective effect by both herbs.
Celik 2007
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A comprehensive review on the stinging nettle revealed anti-prostatic effect, anti-inflammatory activity, immunomodulatory effect, anti-viral and fungistatic effects.
Chrubasik 2007
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Antioxidant capacity changes and phenolic profile of Echinacea purpurea, nettle (Urtica dioica L.), and dandelion (Taraxacum officinale) after application of polyamine and phenolic biosynthesis regulators were studied.
Hudec 2007
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A study on the antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture revealed Urtica dioica agglutinin as a potential antiviral agent.
van der Meer 2007
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Ethanolic and aqueous extracts from five plant species used in Turkish traditional medicine including Urtica dioica were evaluated for in vivo hypercholesterolaemic and antioxidant activities which revealed that Urtica dioica increased the serum HDL concentration.
Avci 2006
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[Effect of Urtica Dioica on bacterial translocation in mechanic icter model.]
Aydin 2006
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Flavonoids, isolated from plant leaves, produced strong inhibitory effect on thrombin-induced platelet aggregation with an IC(50) of 0.25 +/- 0.05 & 0.40 +/- 0.04 mg/mL for genins and heterosidic flavonoids, respectively which supports traditional use of Urtica dioica for cardiovascular diseases.
El Haouari 2006
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Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor shows that the most active extracts, includes Acorus calamus, marjoram, Zea mays, chilli and Urtica dioica.
Rau 2006
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Aqueous Urtica dioica extract stimulated the proliferation of T-lymphocytes of murine splenocytes and suppressed nitric oxide production in lipopolysaccharide-stimulated macrophages without affecting cell viability of murine peritoneal macrophages when tested in vitro.
Harput 2005
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Investigation of some medicinal herbs: Urtica dioica, Taraxacum officinale, Viscum album, and Myrtus communis with alpha-glucosidase inhibitor activity was conducted to identify a prophylactic effect for diabetes in vitro. All plants showed differing potent alpha-glucosidase inhibitory activity.
Onal 2005
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Both exercise and nettle influenced physiological brain functions of Wistar rats. Nettle supplementation reduces free radical concentration and increases the DNA binding of AP-1, was found to be an effective antioxidant and possible antiapoptotic supplement promoting cell survival in the brain.
Toldy 2005
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A preliminary screening of the antiviral activity of Parietaria diffusa, Sambucus nigra and Urtica dioica preparation against the feline immunodeficiency virus infection was proposed.
Uncini Manganelli 2005
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Aqueous extract of Urtica dioica leaves, results in significant inhibition on adenosine deaminase activity of prostate tissue in patients with prostate cancer.
Durak 2004
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The inhibitory effect of stinging nettle leaf extract on the protease activity of botulinum neurotoxin type A and B light chains was investigated.
Gul 2004
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Water extract of nettle (Urtica dioica L.) (WEN), had powerful antioxidant activity, showed antimicrobial activity against nine microorganisms, antiulcer activity against ethanol-induced ulcerogenesis and analgesic effect on acetic acid-induced stretching.
Gulcin 2004
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Examination of the in vitro anti-aggregant effect of five medicinal plants including Urtica dioica showed that all extracts produced a dose-dependent inhibition of thrombin and ADP-induced aggregation but Urtica dioica had a higher IC50 value.
Mekhfi 2004
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The aqueous extract of Urtica dioica (nettle) (250 mg/kg), has a significant antihyperglycemic effect in OGTT model and the effect may be caused in part by the reduction of intestinal glucose absorption. LD(50) is 3.5 g/kg (i.p.).
Bnouham 2003
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The plant chitinases Urtica dioica agglutinin and Arabidopsis thaliana Chia4 proteins were over-expressed in bacteria and the interaction between these proteins and Phytomonas francai surface was analyzed by immunocytochemistry.
Gomes Rocha 2003
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The suppressive effect of stinging nettle leaf extract IDS 30 on the maturation of human myeloid dendritic cells, leading to reduced induction of primary T cell responses may contribute to the therapeutic effect of IDS 30 on T cell mediated inflammatory diseases like rheumatoid arthritis.
Broer 2002
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By the presence of two chitin-binding domains, BjCHI1 resembles the precursor of UDA (Urtica dioica agglutinin) but, unlike UDA, BjCHI1 retains its chitinase catalytic domain after post-translational processing.
Fung 2002
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Aqueous extract of Nettle produces a vasoconstriction of aorta due to activation of alpha1-adrenergic receptors & induces a strong bradycardia through non-cholinergic & non-adrenergic pathways which might compensate for its vascular effect & account for the hypotensive action of Urtica dioica L.
Legssyer 2002
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Two aspects of population structure in a parasitic plant, the greater dodder (Cuscuta europaea) and its host plant, the stinging nettle (Urtica dioica), using allozyme data from 12 host and eight parasite populations were examined.
Mutikainen 2002
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In the lipid peroxidation assay, extracts from leaves of Origanum heracleoticum, Urtica dioica and Tordylium apulum showed a remarkable inhibitory activity (> 50%).
Pieroni 2002
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The monosubstance 13-Hydroxy-octadecatrienic acid is an antiinflammatory substances in Hox alpha (HA) which is a novel stinging nettle (Urtica dioica/Urtica urens) leaf extract used for rheumatic diseases when tested on matrix metalloproteinases in human chondrocytes in vitro.
Schulze-Tanzil 2002
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Urtica dioica can produce hypotensive responses, through a vasorelaxing effect mediated by the release of endothelial nitric oxide and the opening of potassium channels, and through a negative inotropic action.
Testai 2002
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During investigations of micro flora in North Rhine-Westphalia, Germany in the years of 1999 and 2000, some new & rare species of micro fungi as parasites and saprophytes on wild and ornamental plants were collected and identified, including Apomelasmia urticae on Urtica dioica.
Ale-Agha 2001
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Review on current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection indicates that the N-acetylgl ucosamine-specific lectin from Urtica dioica would primarily be targeted at the virus-cell fusion process.
De Clercq 2000
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The antiproliferative effect of 20% methanolic extract of stinging nettle roots observed both in an in vivo model and in an in vitro system clearly indicates a biologically relevant effect of compounds present in the extract.
Konrad 2000
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Two saccharide-binding sites in the structure of Urtica dioica agglutinin suggest that its superantigenic properties arise from the simultaneous fixation of glycans on the T cell receptor and major histocompatibility complex molecules of the T cell and antigen-presenting cell, respectively.
Saul 2000
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It is suggested that part of the antiinflammatory effect of Urtica extract may be ascribed to its inhibitory effect on NF-kappaB activation.
Riehemann 1999
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Stinging nettle lectin interferes with hyphal growth of the fungus Trichoderma viride like the N-terminal domain of endochitinase Ch3 (from chestnut seeds).
Garcia-Casado 1998
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Lignans in Urtica dioica roots bind human sex hormone binding globulin
Schottner 1997
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Urtica dioica agglutinin injection decreases certain mature T-cells bearing V beta 8.3 receptors.
Delcourt 1996
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Binding of Urtica agglutinin to V beta-dependent T cell receptor (TCR) involves J beta segment of the TCR beta chain.
Musette 1996
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Urtica dioica agglutinin (UDA) lectin binds & deletes V beta 8.3+ T cells in MRL lpr/lpr mice, preventing systemic lupus erythematosus-like pathology
Musette 1996
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Urtica dioica root lignan, seco-isolariciresinol or a mixture of isomeric trihydroxy-11-octadecenoic acids reduced binding of human SHBG. Methylation of the latter increased activity 10-fold
Gansser 1995
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Urtica dioica agglutinin, a small lectin containing two homologous 43-amino acid domains, binds the trisaccharide, N,N',N"-triacetylchitotriose
Hom 1995
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Urtica dioica root aqueous extract inhibits binding of 125I-Sex Hormone Binding Globulin (SHBG) to its receptor in a dose related manner starting at 0.6 mg/ml concentration
Hryb 1995
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Lectin from Urtica dioica binds human hyperplastic prostate cells
Kayser 1995
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Analytical Chemistry
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From whole herb of Urtica dioica grown in Nyingchi area, China's Tibet Autonomous Region nine compounds: beta-sitosterol, trans-ferulic acid, dotriacotane, erucic acid, ursolic acid, scopoletin, rutin, quercetin & p-hydroxyl-benzalcohol were isolated. [Article in Chinese]
Ji 2007
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Laser capture microdissection was used for isolating different tissues from the stem of Urtica dioica L. at a semi-preparative scale.
Angeles 2006
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Based exclusively on hyphenated chromatographic techniques the methanolic extracts of Tilia europea, Urtica dioica, Lonicera periclymenum and Hypericum perforatum are initially screened for their antioxidant components via an on-line DPPH and ABTS radical scavenging technique.
Exarchou 2006
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The landsnail Cepaea nemoralis is found to regulate internal Cd levels when fed on Cd-enriched stinging nettle (Urtica dioica) leaves at low, field-relevant concentrations and the study data suggests that Cd excretion via the mucus plays a substantial role in this regulation.
Notten 2006
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A new, simple method for the separation and determination of nitrate ion in nettle based on reversed-phase ion-pair chromatography has been elaborated.
Szabo 2006
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The qualitative and quantitative analysis of individual isolectins in Urtica dioica extracts is described, which is the first report on using capillary electrophoresis (CE) for the analysis of lectins in plant material at all.
Ganzera 2005
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Polyphenol oxidase of nettle (Urtica dioica) was extracted and purified through (NH4)2SO4 precipitation, dialysis, and CM-Sephadex ion-exchange chromatography and was used for its characterization.
Gullcin 2005
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The concentrations of Zn, Cu, Cd and Pb in the compartments of a soil-plant (Urtica dioica)-snail (Cepaea nemoralis) food chain in four polluted locations was investigated.
Notten 2005
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The adaptation of high-pressure freezing and freeze-substitution for ultrastructural analysis of Urtica dioica leaf tissue with special emphasis on chloroplasts was reported.
Pfeiffer 2005
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An in-vial simple method for combined derivatization & extraction of phenolic acids & flavonoids from plant extracts including Urtica dioica, Mentha spicata & Hypericum perforatum grown wild in north-western Greece & their direct determination with GC-MS, is described.
Fiamegos 2004
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Antioxidant and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, reducing powers and the amount of total phenolic compounds of aqueous and/or methanolic extracts of some medicinal plants used in Eastern Turkey including Urtica dioica were studied.
Mavi 2004
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The major compounds isolated from the methanolic extract of Urtica dioica L. were determined by chromatographic, chemical and spectral (UV, IR, (1)H-NMR, (13)C-NMR) methods. Their immunomodulatory activities were studied in vitro by chemotaxis and intracellular killing activity tests.
Akbay 2003
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As, Ca, Cd, Cu, Fe, Mg, Mn, Pb and Zn were determined by ICP-MS and ET-AAS in preparations made from peppermint and nettle leaves after microwave high pressure digestion with nitric acid.
Fijalek 2003
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Urtica dioica agglutinin, a plant lectin from the stinging nettle, consists of a total of seven individual isolectins. One of these structures, isolectin I, was determined at 1.9 A resolution by the X-ray method.
Harata 2001
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The isolectin VI (Urtica dioica agglutinin -VI) was purified and crystal structures of the isolectin and its complex with tri-N-acetylchitotriose were determined by X-ray analysis.
Harata 2000
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Gelatinase B (MMP-9) from mononuclear white blood cells induced by lectins of Urtica, Calystegia, Convolvulus and Colchicum; suppressed by lectins of Datura stramonium, Viscum album, Bauhinia purpurea, Triticum aestivum & Maackia.
Dubois 1998
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Aeropalynological analysis for 1981-1982 and 1991-1992 aimed at establishing a pollen calendar for the city of Salamanca (Spain) afforded the identification of 48 different types of pollen grain including Urtica dioica (nettle).
Hernandez Prieto 1998
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'Changes in the specific activity of radionuclides during the technological processing of nettle'
Ivanova 1996
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Caffeic malic acid in Urtica dioica leaf extract inhibits 5-lipoxygenase and synthesis of leukotriene B4 in a concentration dependent manner
Obertreis 1996
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Acetylated sphingophospholipids with PAF-like activity has so far been reported only in Urtica dioica
Zanglis 1996
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Methanolic extracts of stinging nettle (URTICA DIOICA L.) roots were investigated for aromatase inhibition. Enzyme inhibition was detected only after appropriate chromatographic separation.
Gansser 1995
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Genetics & Molecular Biology
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It is demonstrated that the N-acetylglucosamine-binding protein from Urtica dioica (UDA) prevents HIV entry and eventually selects for viruses in which conserved N-glycosylation sites in GP120 were deleted.
Balzarini 2005
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A full-length cDNA clone, designated Udp1, was isolated from Urtica dioica (stinging nettle), using a polymerase chain reaction based strategy.
Douroupi 2005
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The gene encoding the precursor to stinging nettle (Urtica dioica L. ) isolectin I was introduced into tobacco (Nicotiana tabacum). In transgenic plants this precursor was processed to mature-sized lectin.
Does 1999a
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Genomic fragments encoding precursors for Urtica dioica agglutinin-isolectins have been amplified by five independent polymerase chain reactions on genomic DNA from stinging nettle ecotype Weerselo.
Does 1999b
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UDA (Urtica dioica agglutinin) contains two hevein like domains with two non-identical interacting sites and is specific for chitooligosaccharides. The binding of chitooligosaccharides to UDA was studied by Isothermal Titration Calorimetry.
Katiyar 1999
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Study indicated that interaction between Urtica dioica agglutinin (UDA) and Major histocompatibility class (MHC) - I molecules implicated lectin-binding site(s) of UDA. In addition to MHC-II antigens, MHC-I molecules serve as an alternative ligand for UDA.
Rovira 1999
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The interaction between Urtica dioica agglutinin (UDA) and N-acetylglucosamine (GlcNAc) and its beta(1-4)-linked oligomers was studied by fluorescence titration and isothermal titration microcalorimetry.
Lee 1998
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Contemporary Formulas
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An infusion (Diabole) made of dill (Anethum graveolens), nettle (Urtica dioica) and gingko (Gingko biloba) when given in right dosages could be suitable for reducing blood sugar level significantly in II. type of diabetes mellitus. [Article in Hungarian]
Fodor 2006
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A double blind comparison of Sabal+Urtica vs. finasteride for 48 weeks with 543 patients had comparable results for urine urine flow increase (1.9 vs. 2.4 ml/sec) and symptom decrease (see below)
Sokeland 1997
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Serenoa extract, Pumpkin seeds, Urtica or Pollinis siccae extract are approved in Germany
Vahlensieck 1996
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Sabal extract WS 1473 + Urtica extract WS 1031 improved symptoms for 2080 BPH patients in an open prospective study
Schneider 1995
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Patents
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Conduct a search on Urtica dioica or stinging nettles in the title, abstract or claims section of the
US patent database
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Cultivation, Conservation & Ecology
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The polyphagous butterfly Polygonia c-album, which is currently expanding its range in Britain was studied and apparently has altered its host plant preference from Humulus lupulus to include other hosts (particularly Ulmus glabra and Urtica dioica).
Braschler 2007
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The genetic structure of populations of the two-spotted spider mite Tetranychus urticae was investigated along a south-north European transect spanning from southern France to The Netherlands. Mites were collected on Urtica dioica in 6 sampling zones.
Carbonnelle 2007
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A study on the dispersal of vascular plants in a forest mosaic in eastern Britain by four deer & two lagomorph species showed 101 plant species germinated from faecal pellet material, out of which 56% of the seedlings were of Chenopodium album, Urtica dioica and Agrostis stolonifera.
Eycott 2007
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Crosses were performed between individual male and female plants from different sex ratio families to investigate the inheritance pattern of the sex ratio trait in Urtica dioica.
Glawe 2007
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The diversity of the aphidophagous predators was shown to be higher on nettle than in field crops, particularly the Chrysopidae, the Anthocoridae and the Miridae.
Alhmedi 2006
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Cd, Cu and Zn concentrations in soil, pore water and CaCl(2) extracts of soil, in leaves of the plant species Urtica dioica and in earthworms were determined at 15 field sites constituting a gradient in metal pollution.
Hobbelen 2006
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The differences in the microbial use of non-contaminated and heavy metal contaminated nettle shoot residues in three soils subjected to heavy metal pollution (Zn, Pb, Cu, and Cd) by river sediments was evaluated.
Khan 2006
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A leaf imprinting technique combined with a selective medium was used to document the natural occurrence of Beauveria bassiana on phylloplanes of typical hedgerow plants (grasses, stinging nettle and hawthorn) in May, July and September in a hedgerow in Denmark.
Meyling 2006
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The seed sex ratio of the stinging nettle (Urtica dioica) collected from female plants in the field varied between 0.05 and 0.76, and differed significantly between maternal parents.
de Jong 2005
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The results of greenhouse study suggest that resistance and tolerance of nettles to diverse enemies are free to evolve independently of each other but not completely without direct costs in terms of plant fitness.
Puustinen 2004
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It is examined whether parasite relatedness affects competition between parasitic plants (Cuscuta europaea) that share common host plants (Urtica dioica).
Puustinen 2004a
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