 |
 |
| EVIDENCE FOR EFFICACY (HUMAN DATA) |
|
| |
|
Clinical Trials
|
 |
[A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention and treatment of radiation dermatitis].
Bosley 2003
|
|
| |
Gradual delivery of AV gel to skin by dry-coated Aloe vera gloves produced improved skin integrity, decreased appearance of fine wrinkling, and decreased erythema in occupational dry skin and irritant contact dermatitis.
West 2003
|
|
| |
Aloe vera gel did not significantly reduce radiation-induced skin side effects of breast cancer patients where as aqueous cream was useful in reducing dry desquamation and pain related to radiation therapy
Heggie 2002
|
|
| |
Acemannan Hydrogel Patch significantly reduced the incidence of alveolar osteitis in molar extraction sites compared with clindamycin-soaked Gelfoam.
Poor 2002
|
|
| |
The clinical effects of saline and Aloe vera rinses on periodontal surgical sites. (No abstract)
Rieger 2002
|
|
| |
A clinical trial on whether use of mild soap alone or mild soap + Aloe vera gel would decrease incidence of skin reactions in patients undergoing radiation therapy revealed a protective effect of adding Aloe to the soap regimen only when the cumulative dose increases over time.
Olsen 2001
|
|
| |
Clear benefit could not be established of a gel containing silicon dioxide, aloe
vera, and allantoin for healing of recurrent oral aphthous ulcers in a
randomized 3-4-month trial
Garnick 1998
|
|
| |
Cancer progression was slowed when A. vera tincture (1 ml twice/day) was
added to melatonin (20 mg/day orally) than by melatonin alone in a small trial with 50 cancer patients
Lissoni 1998
|
|
| |
Carrasyn, a hydrogel from aloe approved by the FDA for pressure ulcers, gave no advantage over a moist saline gauze dressing in a randomized trial with 30
patients for 10 weeks
Thomas 1998
|
|
| |
Among cancer patients, radiation therapy-induced dermatitis was not reduced among those getting aloe gel
Williams 1996
|
|
| |
The decline of CD4 in HIV patients was not prevented by acemannan @ 1600
mg/d orally
Montaner 1996
|
|
| |
Slight to moderate chronic plaque-type psoriasis was cured in 4 weeks with 0.5% Aloe extract in 25/30 patients (83.3%) compared to the placebo cure rate of 2/30 (6.6%) and clearing of psoriatic plaques was 328/396 (82.8%) vs placebo 28/366 (7.7%)
Syed 1996
|
|
| |
Burns healed faster with aloe vera gel than vaseline gauze, 12 vs. 18 days in a trial with 27 patients
Visuthikosol 1995
|
|
| |
In a double-blind trial, a combination of celandin, aloe vera and psyllium, showed increased bowel movements, soft stools and less laxative dependence compared to placebo.
Odes 1991
|
|
| |
From 21 women with healing complications after gynecologic surgery, those treated with aloe vera gel required 83 days and those on standard treatment healed in 53 days
Schmidt 1991
|
|
| |
5000 angina patients adding the 'Husk of Isabgol' and 'aloe vera' to their diet had reduced total serum cholesterol, serum triglycerides, fasting and post prandial blood sugar level in diabetic patients, total lipids and also increased HDL
Agarwal 1985
|
|
| |
Double-blind comparison of alophen with its components for cathartic effects. (No abstract)
Chapman 1974
|
|
|
Observational Studies/Case Reports
|
| |
[Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure].
Mitchell 2003
|
|
| |
Review of a total of 108 trials examining 36 herbs and 9 vitamin/mineral supplements, involving 4,565 patients with diabetes revealed that these herbs are generally safe and plants like Aloe vera have positive preliminary results.
Yeh 2003
|
|
| |
Data on atopic dermatitis and chronic venous insufficiency treated with aloe Aloe vera gel and tea tree oil indicated that there is no compelling evidence for their effectiveness as reviewed from the various clinical studies.
Ernst 2002
|
|
| |
Including Aloe vera, 45 plants and their products (active, natural principles and crude extracts) that have been mentioned/used in the Indian traditional system of medicine have shown experimental or clinical evidence of anti-diabetic activity.
Grover 2002
|
|
| |
Beneficial aspects of medicinal plants on skin include: healing of wounds and burn injuries (especially Aloe vera)
Mantle 2001
|
|
| |
Surgeons should question patients about use of common herbal remedies, as some may increase the risk of bleeding, or photosensitivity reaction, and some may be beneficial for wound healing (aloe vera gel).
Pribitkin 2001
|
|
| |
A new bioadhesive patch of Aloe vera hydrogel, tried for aphthous stomatitis found effective in more than 80% of cases with 90% compliance in adhesivity, acceptability and palatability of the formulation. [Article in Italian]
Andriani 2000
|
|
| |
Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively for the prevention and treatment of peptic ulcer and their clinical efficacy documented.
Borrelli 2000
|
|
| |
The effects, clinical studies, side effects, and dosing regimens for aloe vera, arnica, black cohosh, evening primrose oil, and saw palmetto are reviewed.
Cohen 2000
|
|
| |
Studies on Aloe vera, and many other plants indicate that these plants may be of value in selected dermatological indications.
Grimme 1999
|
|
| |
A case of successful treatment of Lichen planus, a disease that involves the skin and mucous membranes, with Aloe vera is described.
Hayes 1999
|
|
| |
Review of Aloe has revealed the therapeutic claims in inflammation, immuno-modulatory properties, antidiabetic, anticancer and antibiotic activities
Reynolds 1999
|
|
| |
Review of authentic literature of Aloe vera based on controlled clinical trials revealed that, even though there are some promising results, clinical effectiveness of oral or topical aloe Aloe vera is not sufficiently defined at present.
Vogle 1999
|
|
| |
Encouraging results for topical and oral aloe treatment of chronic venous leg ulcers call for larger research studies
Atherton 1998
|
|
| |
Nutritional supplements such as aloe vera and other plant derived saccharides
appeared to help improve fibromyalgia and chronic fatigue syndrome in 50
patients followed 9 months
Dykman 1998
|
|
| |
Natural cancer therapy with pineal indole melatonin plus Aloe vera extracts may produce some therapeutic benefits, at least in terms of stabilization of disease and survival, in patients with advanced solid tumors.
Lissoni 1998
|
|
| |
A review which discusses many agents used in treating Inflammatory bowel disease including the aloe vera derivative acemannan.
Robinson 1998
|
|
| |
Review of non conventional topical therapies for wound care including aloe
vera, etc
Rund 1996
|
|
| |
Aloe may be used in domestic conditions for increasing the defensive forces of the body during radiation lesions. [Article in Ukrainian]
Iena IaM 1993
|
|
| |
Dermabrasion healing was faster in areas where aloe was added to
polyethylene oxide gel dressing
Fulton 1990
|
|
| |
In frostbite, application of Aloe vera cream combats the local vasoconstrictive effects of thromboxane.
McCauley 1990
|
|
| |
Combination of chemotherapy in cases of pulmonary tuberculosis using desensitizing agents and tissue preparations (a suspension of placenta tissue and aloe) had an immunomodulating effect. [Article in Russian]
Nersesian
|
|
| |
Aloe injection lowered sGPT levels by 86.8%. in 38 patients of chronic hepatitis with positive HBsAg. [Article in Chinese]
Fan 1989
|
|
| |
Studies and case reports provide support for the use of aloe vera in the treatment of radiation ulcers and stasis ulcers in humans.
Klein 1988
|
|
| |
Three patients with chronic osteoma cutis secondary to acne vulgaris were treated postoperatively, with Aloe-vera-soaked polyethylene oxide gel dressings with excellent cosmetic results.
Fulton 1987
|
|
| |
Dried sap of the Aloe plant was studied in 5 patients with non-insulin-dependent diabetes and in Swiss albino mice made diabetic using alloxan. Aloe contains a hypoglycaemic agent which lowers the blood glucose.
Ghannam 1986
|
|
| |
Modern clinical use of the mucilaginous gel from the parenchymatous cells in
the leaf pulp began in the 1930s, with reports of successful treatment of X-ray
and radium burns
Grindlay 1986
|
|
| |
"Aloe Vera in dentistry " (no abstract)
Sturm 1984
|
|
| |
Use of aloe in complex treatment of patients with focal pulmonary tuberculosis. [Article in Russian](No abstract)
Kurilenko 1974
|
|
|
Traditional and Folk Use
|
| |
Hispanic or non-Hispanic whites aged between 65-74 years revealed that half of them had used herbal medicines like spearmint, chamomile, aloe vera, garlic, brook-mint, osha, lavender, ginger, ginseng, and camphor.
Zeilmann 2003
|
|
| |
77% of population in United States-Mexico border city have been found to use Complementary and alternative medicine. One of the common herbal remedy was aloe vera (8.5%).
Rivera 2002
|
|
| |
Mexican women living in the United States were found to use herbal therapies of traditional Mexican culture, including manzanilla (chamomile), savila (aloe vera), ajo (garlic), una de gato (cat's claw), and yerba buena (spearmint).
Zenk 2001
|
|
| |
Aloe vera, Bryophyllum pinnatum, Citrus sp. and Momordica charantia were
the main medicinal plants being used for poultry health problems in Trinidad
and Tobago
Lans 1998
|
|
| |
100 adults in managed care surveyed about herbal use found that the most
used are aloe vera, honey, peppermint, garlic, eucalyptus, and rose hips
Brown 1991
|
|
| |
Traditional medicinals entering modern health include Ammi visnaga,
Cymbopogon proximus, Nigella sativa, Aloe vera, Urginea maritima,
Phytolacca americana, Euphorbia sp., Glycyrrhiza glabra, Cynara scolymus
and Solanum laciniatum
Sayed 1980
|
|
 |
Monograph in "A Modern Herbal" by Mrs. M. Grieve at
botanical.com
|
|
|
|
|
Adverse Effects & Toxicity
|
| |
39-year-old liver transplant patient who took a laxative containing aloe for ten months, developed melanosis coli. One year after stopping the anthranoid, the pigments disappeared but a polypoid lesion appeared.
Willems 2003
|
|
| |
The FDA?s final ruling states that the stimulant laxative ingredients of aloe (including aloe extract and aloe flower extract) in over-the- counter (OTC) drug products are not generally recognized as safe and effective, or are misbranded.
FDA 2002
|
|
| |
Life-long Aloe vera ingestion does not cause any obvious harmful and deleterious side effects in SPF Fisher rats and could also be beneficial for the prevention of age-related pathology.
Ikeno 2002
|
|
| |
A 47-year-old South African, developed acute oliguric renal failure and liver dysfunction after ingestion of an herbal remedy, found by Mass spectrometric and chromatographic analysis, to contain Cape aloes.
Luyckx
|
|
| |
The anthraquinones aloe-emodin, emodin and rhein were found to be phototoxic in vitro. Probable mechanism may be through the involvement of singlet oxygen and stable photoproducts.
Vargas 2002
|
|
| |
Aloe emodin was found to generate singlet oxygen when irradiated with UV light and this photochemical mechanism is the most likely pathway responsible for the phototoxicity of Aloe emodin.
Vath 2002
|
|
| |
In Ovalbumin sensitized rat models treated intranasally with aloe vera there was differentiation of CD4+ lymphocytes, mediated through regulating the expression of Th1 and Th2 cytokines. Aloe vera treatment may be a selective method to treat allergic rhinitis. [Article in Chinese]
Yu 2002
|
|
| |
Medium Lethal Concentrations (LC50 value) of Aloe vera (L.) obtained from Artemia salina L. the brine shrimp larva, was equivalent to in vivo LD50 value done in mice and this could be an alternative method for predicting acute toxicity of plant extracts.
Logarto Parra 2001
|
|
| |
Popular remedies that can cause dermatological side-effects include St John's Wort, kava, aloe vera, eucalyptus, camphor, henna and yohimbine.
Ernst 2000
|
|
| |
Inhibition of the catalytic activity of topoisomerase II contributes to anthraquinone (emodin, danthron, and aloe-emodin) induced genotoxicity and mutagenicity.
Mueller 1999
|
|
| |
Immunosuppressed mice treated with the whole extract of Aloe vera (L) achieved restoration of immunological parameters in cellular immune response and phagocytosis but not humoral immunity.
Oronzo-Barocio 1999
|
|
| |
Formulations of acemannan as a denture adhesive were evaluated for pH changes and adhesive strength in dry and wet conditions. They had some
cytotoxicity to human gingival fibroblasts
Tello 1998
|
|
| |
Toxic low mol. wt compounds of Aloe vera gel, induced disruption of intercellular junctions of chicken fibroblasts and inhibited the production of reactive oxygen species by human polymorphonuclear leukocytes.
Avila
|
|
| |
Data from animal, human metabolism or kinetic studies, clinical trials and rodent carcinogenicity studies do not support concern that emodin and aloe-emodin poses a genotoxic risk to humans under prescribed use conditions.
Brusick 1997
|
|
| |
Tk-mutations in mouse lymphoma L5178Y cells were induced by emodin,
danthron and aloe-emodin. They also inhibited topoisomerase II-mediated
decatenation
Muller 1996
|
|
| |
Dimethylhydrazine-induced colorectal tumors in male mice were not promoted
by aloin- or sennoside-enriched diets (0.03%)
Siegers 1993
|
|
|
|
| |
Acemannan showed no toxicity at 5% of rat diet for 2 weeks or 2 gm/kg to
rats for 6 months or 1.5 gm/kg to dogs for 3 months
Fogelman 1992b
|
|
| |
No significant toxicity were found with acemannan at 80 mg/kg iv or 200
mg/kg ip in mice, 15 mg/kg iv or 50 mg/kg ip in rats, and 10 mg/kg iv or 50
mg/kg ip in dogs. Increased macrophages & monocytes were observed
Fogleman 1992a
|
|
| |
The LD50 values in mice vary from <250 to >1500 mg/kg IP. In rats there was CNS depression. Post mortem findings showed haemorrhagic lesions. Several rats died within 36 hours of injection, but no abortifacient activity was seen.
Parry 1992
|
|
| |
Burning sensation was experienced by 4 adults after application of aloe vera or
vitamin E preparations to skin that had been subjected to a chemical peel or
dermabrasion
Hunter 1991
|
|
| |
Contact dermatitis to Aloe arborescens (No abstract.
Shoji 1982
|
|
| |
A 47 year old man exhibited hypersensitivity after 4 years of oral and topical
aloe
Morrow 1980
|
|
| |
[Acute bullous allergic dermatitis due to local application of aloe leaves]
[Article in Russian] (No abstract)
Savchak 1977
|
|
| |
[Case of an allergic reaction to the administration of aloe juice into the nose] [Article in Russian] (No abstract
Diba 1974
|
|
| |
[Anaphylactic shock after injection of aloe] [Article in Russian] (No abstract)
Trakhtenberg 1970
|
|
| |
Warning it might cause nausea & dermatitis but no references
U Arizona
|
|
|
Interactions
|
| |
A Review of herbal medication revealed aloe latex to interact with corticosteriods.
Abebe 2003
|
|
| |
Aloin may get metabolized to aloe-emodin (a quinone aglycone) after its ingestion, which may cause acceleration of the ethanol metabolism in rats in vivo.
Chung 1996
|
|
| |
Aloe caused a faster elimination of ethanol from blood of normal rats by preventing the effects of ethanol in decreasing the microsomal enzyme activities relating to its own metabolism
Sakai 1989
|
|
| |
Aloes treatment revealed antimetastatic properties, reduction of tumor mass, metastatic foci and metastasis frequency. It also potentiates the antitumor effect of 5-fluorouracil and cyclophosphamide. [Article in Russian]
Gribel 1986
|
|
|
Animal Studies
|
| |
Life-long intake of aloe had superior anti-oxidative action against lipid peroxidation in vivo, as indicated by reduced levels of hepatic phosphatidylcholine hydroperoxide in rats.
Lim 2003
|
|
| |
Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin in rats.
Muller 2003
|
|
| |
Freeze-dried whole leaves of Aloe arborescens var. natalensis when given with food (5%) to rats, inhibited azoxymethane induced DNA adduct (O(6)-methylguanine and reduced CYP2E1 enzymatic activity.
Shimpo 2003
|
|
|
Pharmacodynamics
|
| |
Aloe vera stimulates gap junctional intercellular communication and proliferation of human skin fibroblasts in diabetes mellitus. It contains a compound that neutralizes and binds with FGF-2 receptor.
Abdullah 2003
|
|
| |
Aloe gel and aloins inhibited Clostridium histolyticum collagenase reversibly and non-competitively and also activity of human stimulated granulocyte matrix metallooproteinases, destabilizing their structure.
Barrantes 2003
|
|
| |
Radical-scavenging effects of Aloe arborescens Miller prevented pancreatic islet B-cell destruction caused by specific pancreatic islet toxins such as Sz, Ax, and HX-XO in rats.
Beppu 2003
|
|
| |
Aloe-emodin affects mice leukemia cells N-Acetyltransferases activity, gene expression (NAT1 mRNA) and DNA-AF on adduct formation.
Chung 2003
|
|
| |
In vitro susceptibilities of Shigella flexneri and Streptococcus pyogenes to inner gel of Aloe barbadensis Miller are described.
Ferro 2003
|
|
| |
Propionibacterium induced reactive oxygen species and pro-inflammatory cytokines from polymorphonuclear leukocytes and monocytes are inhibited by Azadirachta indica and some other herbs but not by Aloe vera.
Jain 2003
|
|
| |
S-100 proteins identified from Aloe, plantain and bilberry inserted membranotropic effect and increased cell growth rate in extremely low doses in short-term tissue culture of mouse's liver in vitro. [Article in Russian]
Krasnov 2003
|
|
| |
Aloe-emodin treatment results in translocation of tumor suppressor gene p53, to the mitochondria inter-membrane space in neuroblastoma cell lines and it could also kill tumor cells harboring p53 mutant genes.
Pecere 2003
|
|
| |
Molecules from Aloe vera are known to possess both mast cell stabilizing and gastrointestinal cytoprotective activity.
Penissi 2003
|
|
| |
A glycoprotein (14 kDa) isolated from Aloe vera gel showed radical scavenging activity against superoxide anion, inhibition of cyclooxygenase-2 and reduction of thromboxane A 2 synthase.
Yagi 2003
|
|
| |
Expression of p38 protein is an important determinant of apoptotic death induced by aloe-emodin in human lung nonsmall cell carcinoma cell line.
Yeh 2003
|
|
| |
Aloe-emodin inhibited cell proliferation and induced apoptosis in two human liver cancer cell lines. Mechanisms involved are i) cell cycle arrest in G1 phase and ii) increase in Fas/APO1 receptor and Bax expression.
Kuo 2002
|
|
| |
1,4-naphthoquinone-induced toxicity in rat cultured hepatocytes was inhibited by aloe extract, and this protective effect was due to maintenance of cellular thiols, especially protein-SH.
Norikura 2002
|
|
| |
Aloe emodin was found to be nontoxic for normal cells but to possess specific toxicity for neuroectodermal tumor cells of Merkel cell carcinoma cell line.
Wasserman 2002
|
|
| |
Aaloesin derivatives, isorabaichromone, feruloylaloesin and p-coumaroylaloesin showed antioxidant activity, DPPH radical and superoxide anion scavenging activities and also inhibited cyclooxygenase (Cox)-2.
Yagi 2002
|
|
| |
A glycoprotein fraction is involved in the wound-healing effect of aloe vera via cell proliferation and migration which was confirmed by three-dimensional raft culture model and in hairless mice.
Choi 2001
|
|
| |
Acemannan could induce maturation of immature dendritic cells which was supported by increased allogeneic mixed lymphocyte reaction and IL-12 production and abolished by chemical sulfation.
Lee 2001
|
|
| |
A basic peroxidase was identified in commercial gel of Aloe barbadensis with activity localised in the vascular system of inner aqueous leaf parenchyma. It may scavenge H2O2 in skin surface.
Esteban 2000
|
|
| |
Diethylhexylphthalate isolated from Aloe vera Linne has potent antileukaemic effect (10 microg mL), on human leukaemic cells.
Lee 2000
|
|
| |
Di(2-ethylhexyl)phthalate isolated from Aloe vera Linne, showed anti-mutagenic effects in Salmonella typhimurium strains and anti-tumour effects against three leukaemic cell lines.
Lee 2000a
|
|
| |
Cellulase modified Aloe polysaccharide activated, macrophage cells and stimulated fibroblast growth while, native Aloe barbadensis gel had no effect on macrophage activation.
Qiu 2000
|
|
| |
Alprogen purified from aloe inhibits multiple signals as well as blocking Ca(2+) influx caused by, mast cells activated with specific antigen-antibody reactions, followed by inhibition of histamine and leukotriene release.
Ro 2000
|
|
| |
Different extracts of Aloe and isolated pure components were screened for antifungal activity and evaluated for toxicity against Aspergillus niger, Cladosporium herbarum and Fusarium moniliforme.
Ali 1999
|
|
| |
Efects of Aloe vera on neurotransmission process of crayfish Neuro Muscular Junction preparation suggest that these effects may partially account for Aloe's analgesic and antiinflammatory effects.
Friedman 1999
|
|
| |
Polysaccharides of Aloe barbadensis Miller and some other plants produced both anti-genotoxic and anti-tumor promoting activities in in vitro models and, considered as potential agents for cancer chemoprevention.
Kim 1999
|
|
| |
A Beta-sitosterol from Aloe vera gel showed i) angiogenic activity in
chorioallantoic membrane of chick embryo, ii)in the presence of heparin, neovascularization in mouse Matrigel plug assay and iii) motility of human umbilical vein endothelial cells in wound migration assay.
Moon 1999
|
|
| |
Effect of aloes and biotritis, on lipid peroxidation in parodontium tissues revealed biotritis has a more considerable parodontoprotective effect than aloes[Article in Russian].
Volik 1999
|
|
| |
In vitro angiogenic activity assay revealed a fraction of Aloe vera gel increased proliferation of calf pulmonary artery endothelial cells and induced these cells to invade type 1 collagen gel to form capillary-like tube.
Lee 1998
|
|
| |
Aloesin stimulates proliferation of cultured human hepatoma SK-HEP-1 cells by inducing intracellular cyclin E/CDK2 kinase complex and CDC25A, there by up-regulates cyclin E-dependent kinase activity.
Lee 1997
|
|
| |
Aloe vera gel contains at least two small molecular weight immunomodulators that may prevent UV-B rays induced immune suppression in skin.
Lee 1997a
|
|
| |
Short term exposure of resident murine peritoneal macrophages with acemannan upregulates respiratory burst, phagocytosis and candidicidal activity.
Stuart 1997
|
|
| |
Glycoprotein fraction prepared from leaf gel of Aloe barbadensis Mill. promoted cell growth, while neutral polysaccharide fraction did not show any growth stimulation.
Yagi 1997
|
|
| |
7.5% and 10% lyophilized Aloe barbadensis proved to be spermicidal due to micro elements which were toxic to tail causing immobilization of spermatozoa but produced no irritation or ulceration of rabbit vaginal epithelium.
Fahim 1996
|
|
| |
Acemannan stimulates mouse macrophage cytokine production, nitric oxide release, surface molecule expression, and cell morphologic changes suggesting it may function through macrophage activation.
Zhang 1996
|
|
| |
Cultures of chicken spleen cells and HD11 line cells produce nitric oxide in response to Acemannan which may be mediated through macrophage mannose receptors and accountable for the immunomodulatory effects.
Karaca 1995
|
|
| |
A lectin (35 kDa) isolated from leaf skin of Aloe arborescens showed hemagglutinating activity in rabbit erythrocytes and strong mitogenic activity towards mouse lymphocytes.
Koike1995
|
|
| |
20.8 micrograms/mL of aqueous extract of Aloe barbadensis Miller inhibited within 24 hours 50% of Trichomonas vaginalis. Similar results were obtained at 48, and 72 hours, with a lower concentration.[Article in Spanish].
Rojas 1995
|
|
| |
Aloe extract and purified Aloe emodin inactivated herpes simplex virus type 1 and 2, varicella-zoster virus, pseudorabies virus and influenza virus except adenovirus and rhinovirus.
Sydiskis 1991
|
|
| |
Low -molecular constituents of an aqueous gel-extract inhibit release of reactive oxygen species by PMA-stimulated human PMN leucocytes which may be due diminished availability of intracellular free Ca-ions.
't Hart 1990
|
|
| |
An anti-complementary polysaccharide with immunological adjuvant activity was isolated from leaf parenchyma gel of Aloe vera which inhibited the opsonization of zymosan.
t'Hart 1989
|
|
| |
Upon ultrafiltration of Aloe vera gel, high molecular fraction obtained, depleted both classical and alternative pathway complement activity but low- molecular fraction could only inhibit PMN leucocytes medicated actions.
Hart 1988
|
|
| |
Aloin and aloe-emodin present in the dry aloe extract inhibited protein biosynthesis in vitro by affecting the [14C]-leucine incorporation into proteins.
Paszkiewicz-Gadek 1988
|
|
| |
A glycoprotein containing 34% carbohydrate was isolated from Aloe arborescens which stimulated DNA synthesis in baby hamster kidney cells and also had lectin like action and reacted with sheep blood cells.
Yagi 1985
|
|
| |
Two lectins isolated from Aloe arborescens Mill. One has hemagglutinating activity; other has hemagglutinating activity, mitogenic activity ,serum proteins precipitating activity, and complement C3 activating activity.
Suzuki 1979
|
|
|
|
| |
[The effects of prednisolone, indomethacin, and Aloe vera gel on tissue culture cells].
Brasher 1969
|
|
| |
[Investigations of antibacterial activity in the aloe].
Bruce 1967
|
|
| |
[Studies on anti-bacterial and anti-fungal activities of Cape aloe] [Article in Japanese].
Soeda 1966
|
|
|
Analytical Chemistry
|
| |
A HPLC method was developed for the simultaneous determination of five hydroxyanthraquinones (aloe-emodin, rhein, emodin, chrysophanol, and physcion) in medicinal materials and experiment samples
Ding 2003
|
|
| |
Three-year-old Aloe vera contained significantly higher levels of polysaccharides and flavonoids than two- and four-year-old Aloe vera, and extract of three-year-old Aloe vera exhibited the strongest radical scavenging activity.
Hu 2003
|
|
| |
Two major metabolites, 10-hydroxyaloin B and deacetyllittoraloin were identified
in Aloe littoralis by high-performance liquid chromatography-nuclear magnetic resonance spectroscopy.
Karagianis 2003
|
|
| |
Analytical HPLC-MS studies of exudate of Aloe secundiflora revealed phenolic compounds, mainly anthrones (aloenin, aloenin B, isobarbaloin, barbaloin ), chromones and phenylpyrones.
Rebecca 2003
|
|
| |
To distinguish the 4 Aloe species viz. Aloe vera, A. ferox and A. africana from Aloe arborescens in commercial food products random amplified polymorphic DNA analysis method has been developed [Article in Japanese].
Shioda 2003
|
|
| |
Cinnamoyl, p-coumaroyl, feruloyl, caffeoyl aloesin, and related compounds were isolated from Aloe species and their antiinflammatory and antioxidative activities were attributed to acyl ester groups in aloesin and related compounds.
Yagi 2003
|
|
| |
A method of derivatization of carbohydrates with 1-phenyl-3-methyl-5-pyrazolone (PMP) was developed to analyze carbohydrates in Aloe powder.
Zhang 2003
|
|
| |
An accurate method to quantitatively determine Barbaloin in aloe capsule by high performance liquid chromatography [Article in Chinese].
Chen 2002
|
|
| |
Colour reaction to identify aloes (Rosenthaler reaction), is better with 1,3-dibromo-5,5-dimethylhydantoin (DBH) than with elemental bromine which has some environmental and economical concern.
Hilp 2002
|
|
| |
Anthraquinone contents of Aloe such as barbaloin, homonataloin, aloeresin and aloenin showed variation between young to old leaves and from central part to margin of leaves. [Article in Chinese]
Shen 2002
|
|
| |
Investigations on contents of aloe drinks revealed presence of Barbaloin and isoBarbaloin in 30 of 31 samples and Aloin-dimers A, B, C and D in 8 of 31 samples. [Article in Japanese]
Shindo 2002
|
|
| |
Isolation of three C-glycosyl chromones, four anthraquinones and a mixture of phytosterols from the leaves of Aloe rubroviolacea reported.
Blitzke 2001
|
|
| |
Aloenin, barbaloin and isobarbaloin in Aloe vera and Aloe arborescens were determined within 15 minutes by micellar electrokinetic chromatography.
Kuzuya 2001
|
|
| |
Aloeride, an immunostimulatory polysaccharide charactrerized from commercial aloe vera juice comprises only 0.015% of its dry weight, but accounts fully for macrophage activation.
Pugh 2001
|
|
| |
Phytochemical investigation of leaf exudate of Aloe marlothii resulted in isolation of a new chromone and a new anthrone.
Bisrat 2000
|
|
| |
A phenolic antioxidative compound was isolated from methanolic extract of Aloe barbadensis by combination of column and thin-layer chromatography.
Lee 2000
|
|
| |
Capillary zone electrophoresis, an easy and low-cost method was developed to quantitatively analyze active components of Aloe vera L. [Article in Chinese].
Wang 2000
|
|
| |
Two lectins (glycoproteins) containing approximately 5% neutral sugar were separated and partially purified from leaf pulp of Aloe vera L.
Akev 1999
|
|
| |
123 chemicals containing 42 alcohols, 23 terpenoids, 21 aldehydes, 9 esters, 8 ketones, 6 acids, 5 phenols, and 9 miscellaneous compounds were identified in aloe leaves using gas chromatography and mass spectrometry.
Umano 1999
|
|
| |
10-hydroxyaloin B 6'-O-acetate, an oxanthrone, was identified in Aloe claviflora
leaf exudate
Dagne 1998
|
|
| |
Determination of aloesin from plasma by HPLC
Kim 1998
|
|
| |
The anthraquinone chrysophanol (1,8-dihydroxy-3-methylanthraquinone) is
transformed, by P450 oxidation, to aloe-emodin (1,
8-dihydroxy-3-hydroxymethylanthraquinone)
Mueller 1998
|
|
| |
Verectin antibody showed differential immunoreactivities against nondialysable
fractions of A. arborescens, A. chinensis, and A. vera
Yagi 1998
|
|
| |
Analysis of peroxidase activity and soluble protein content in leaves of Aloe vera by spectrophotometric method showed variations in upper and lower most parts of leaves [Article in Chinese].
Gao1997
|
|
| |
A new chromone (8-[C-beta-D-[2-O-(E)-cinnamoyl] glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone), isolated from Aloe barbadensis exhibited topical anti-inflammatory activity.
Hutter 1996
|
|
| |
7 superoxide dismutases were found in aloe, 32-42 kD. 2 appear to be
mangano-SODs and 5 cupro-zinc SODs
Sabeh 1996
|
|
| |
The major components are in constant ratio of 4:3:2 of aloeresin A, aloesin,
and aloin (both epimers) throughout the natural distribution range. Aloinoside A
and aloinoside B more frequent in the western region
van Wyk 1995
|
|
| |
Simultaneous HPLC analysis of aloesin, aloeresin A, hydroxyaloin, aloin A
and B and aloinoside A and B
Zonta 1995
|
|
| |
"Determination of the position of the O-acetyl group in a beta-(1-->4)-mannan
(acemannan) from Aloe barbardensis " (no abstract)
Manna 1993
|
|
| |
Rapid sensitive detection of the laxatives phenolphthalein, danthron, rhein,
aloin, and bisacodyl and its metabolites in urine by HP-TLC
Perkins 1993
|
|
| |
Glutathione peroxidase activity in aloe gel extracts is attributed to a 62 kD
protein, composed of four 16 kD subunits containing one atom of selenium per
subunit
Sabeh 1993
|
|
| |
"Components of the gel of Aloe vera (L.) " (no abstract)
Yamaguchi 1993
|
|
| |
Iso-aloesin, C19H22O9, which is
2-acetonyl-6-C-beta-D-glucopyranosyl-7-hydroxy-5-methyl-chromone, from the
leaves of Aloe vera
Yuan 1993
|
|
| |
Acemannan is the USAN-accepted name for long-chain polydispersed
beta-(1,4)-acetylated polymannose with interspersed 0-acetyl groups with a
mannose monomer/acetyl ratio of approximately 1:1 and extracted from Aloe
Fogleman 1992
|
|
| |
Human feces bacteria converts aloesin (aloeresin B) to
2-acetonyl-7-hydroxy-5-methylchromone (aloesone) and
dl-7-hydroxy-2-(2'-hydroxypropyl)-5-methylchromone (aloesol) by cleaving the
C-glucosyl bond
Che 1991
|
|
| |
[Isolation and identification of aloesin from the leaves of Aloe vera L. var, chinensis (Haw.) Berger.] [Article in Chinese].
Yuan 1991
|
|
| |
[Gas chromatographic and mass spectral determination of aloenin in skin-care cosmetics].
Nakamura 1990
|
|
| |
Glyoxalase I and glyoxalase II, from the outer green rind of Aloe vera leaves,
are 44 & 27 kD
Norton 1990
|
|
| |
Chrysarobin can be prepared by oxidative cleavage (FeCl3) of aloin. Emodin
anthrone can be prepared by the action of aquous sodium tetraborate on aloin
Rychener 1989
|
|
|
|
| |
Structure determination of polysaccharides in Aloe saponaria (Hill.) Haw. (Liliaceae).
Yagi 1984
|
|
| |
Aloenin, magnesium lactate, aloe-emodin, barbaloin, and succinic acid, were
found in the leaf juice of Aloe arborescens. Aloenin & magnesium lactate
inhibit gastric juice secretion of rats
Hirata 1977
|
|
| |
[Aloe mannan, a ploysaccharide, from Aloe arborescens var. natalensis].
Yagi 1977
|
|
| |
"Studies on the constituents of Aloe arborescens Mill. var. natalensis Berger.
II. The structures of two new aloesin esters " (no abstract)
Makino 1974
|
|
| |
"Comparison of various methods for the spectrophotmetric determination of
aloin in aloe DAB 7-DDR " (no abstract)
Thieme 1973
|
|
| |
"Chromones in aloe species. I. Aloesin--a C-glucosyl-7-hydroxychromone "
(no abstract)
Holdsworth 1971
|
|
| |
"The assessment of purgative principles in aloes" (no abstract)
Mapp 1970
|
|
| |
[A comparative investigation of methods used to estimate aloin and related compounds in Aloes].
McCarthy 1970
|
|
| |
[Anthraquinone drugs. I. Thin-layer chromatographic identification of aloes, cascara, senna, and certain synthetic laxatives in pharmaceutical dosage forms].
Gyanchandani 1969
|
|
| |
[Distribution of glycosyl compounds in South African Aloe species].
McCarthy 1969
|
|
| |
[Methods of quantitative determination of aloin][Article in Russian].
Tareeva 1968
|
|
| |
Recommended methods for the evaluation of drugs. Prepared by the Joint Committee of the Pharmaceutical Society and the Society for Analytical Chemistry. The chemical assay of aloes.
[No authors listed] 1967
|
|
| |
[Research on drugs with anthraquinone bases. XIV. Isolation of a new heteroside from Senna leaves: diglucoside of aloe emodin dianthrone] [Article in French].
Lemli 1967
|
|
|
| |
