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| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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Clinical Trials
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Update of 2003 Cochrane evidence-based review of Chinese medical herbs for chemotherapy side effects in colorectal cancer patients found that results suggest that decoctions of Huangqi compounds may stimulate immunocompetent cells and decrease side effects in patients treated with chemotherapy.
Taixang 2005
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The study on the effects of six aqueous extracts of Chinese medicine on sperm motility characteristics of 30 infertile male volunteers revealed that Astragalus membranaceus could enhance the motility of human spermatozoa in vitro.
Lin 2004
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Update of 2002 Cochrane evidence-based review of herbal medicines for viral myocarditis found that in low-quality studies performed in China Astragalus membranaceus (either as single herb or compound of herbs) showed significant effects on improving arrhythmia, CPK levels, and cardiac function.
Liu 2004
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Astragalus membranaceus (AM) modulate the imbalance state of Th1/Th2 in 106 patients with herpes simplex keratitis (HSK) and improve their immune function disturbance which shows the significance of AM in treating HSK.[Article in Chinese]
Mao 2004
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[Effect of astragalus injection on insulin resistance in auxiliary treating patients with diabetes mellitus type 2][Article in Chinese].
Huang 2003
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Astragalus Injection improve the immune function [CD4 level and CD4/CD8 ratio increased, levels of soluble interleukin-2 receptor, IgG and IgA lowered significantly] in congestive heart failure (CHF) patients and can used in the treatment of CHF. [Article in Chinese].
Liu 2003
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The clinical improving rate and quality of life elevation rate in 60 patients with advanced non-small cell lung cancer were found to be 80.4% and 43.3% respectively in Astragalus (i.v. drip 60 ml/day) treated group as against 50.0% and 23.3% respectively in control group given chemotherapy alone.
Zou 2003
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The total effective rate of 89.47% was observed in 76 patients with chronic prostatitis administered Nanmiqing capsule (with Astragalus memberanaceus as one of the ingredient),compared to the control group (71.88%).[Article in Chinese].
Dai 2002
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Astragalus injection supplemented with chemotherapy by i.v in 120 tumour patients showed inhibition of tumor development, decreased chemotherapy toxicity, elevated immune function of organism and improved quality of life in patients. [Article in Chinese].
Duan 2002
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The elevated levels of the plasma endothelin-1, platelet granule membrane protein (GMP-140), thromboxane B2 and 24 hrs urinary albumin excretion rate in 86 early diabetic nephropathy patients were lowered by Astragalus injection treatment.[Article in Chinese].
Liu 2001a
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Based on one low quality trial, the medicinal herb 'Jianpi Wenshen recipe' may have antiviral activity in asymptomatic carriers of hepatitis B virus. However, firm evidence for effect of Chinese medicinal herbs for asymptomatic hepatitis B virus carriers is awaited.
Liu 2001b
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Salvia miltiorrhiza & Astragalus membranaceus improved portal hypertension in 42liver cirrhotic patients as they decreased the diameter, quantity of blood flow in portal & splenic vein but increased the speed of blood flow & improved the liver fibrosis indexes.[Article in Chinese].
Tan 2001
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A triplex superimposed treatment scheme of lamivudine, IFN alpha-2b, Astragalus membranaceus was chosen as a treatment scheme for patients who were on the state of hepatitis B (HBV) high replication, which had better efficacy than lamivudine alone.
Wu 2001
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Effect of integrated traditional Chinese medicine which includes Astragalus membranaceus and western medicine,(TCM-WM) in 164 patients improved clinical symptoms and heart function in the TCM-WM group compared to control group and can be tried to treat dilated cardiomyopathy.[Article in Chinese].
Yang 2001
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Astragalus memberanaceus, Codonpsis pilosual and Glycyrrhiza uralensis appear to decrease the airway responsiveness of the patients with asthma.
Wang 1998
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The combination therapy of western and traditional Chinese medicine including Astragalus membranaceus was an effective method in treating 30 patients with acute viral myocarditis.[Article in Chinese].
Gu 1996
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The treatment of 92 ischemic heart diseased patients with Astragalus membranaceus was significantly more effective than Nifedipine and Tab.Salviae miltiorrhizae treated group with 82.6% improvement in electrocardiogram. [Article in Chinese].
Li 1995
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Astragalus membranaceus strengthen the left ventricular[LV] function and had an effect of anti- oxygen free radical in 43 patients with acute myocardial infarction. The ratio of pre-ejection period/LV ejection time correlated with superoxide dismutase and lipid peroxidation.[Article in Chinese].
Chen 1995
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Sanhuang (Astragalus membranaceus, Coptis chinensis, Scutellaria baicalensis) inhibits platelet aggregation in patients as well as aspirin 50 mg/day
Huang 1995
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Routine therapy combined with Astragalus membranaceus could significantly enhance OKT3, OKT4 and OKT4/OKT8 ratio in patients with viral myocarditis. [Article in Chinese].
Huang 1995b
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F3, an immuno-regulatory component of Astragalus membranaceus was shown capable of potentiating the LAK cell inducing activity of rIL-2 and thus minimize the later's toxic side effects when used in vivo.
Chu 1994
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Astragalus membranaceus, a Qi-tonic, increased the cardiac output from 5.09 +/- 0.21 to 5.95 +/- 0.18 L/min 2 weeks after it was administered in 20 patients with angina pectoris. [Article in Chinese].
Lei 1994
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Total cholesterol, triglyceride, apoproteins and lipoprotein-a decreased by Jian Yan Ling (Succinum, Pteria margaritifers & Astragalus membranaceus etc.) in a double blind study with 128 hyperlipemia patients
Lu 1994
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Baoyuan Dahuang Decoction which includes 6 drugs including Astragalus membranaceus improved the quality of life of 56 chronic renal failure patients by reducing the urea nitrogen, adjusting the anemia and regulating the membrane function. [Article in Chinese].
Sheng 1994
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Intervention of iv lidocaine & iv Astragalus membranaceus for 2 weeks was studied on 16 & 22 patients respectively with positive ventricular late potentials. RMS 40 was enlarged only after treatment of A.membranaceus but duration of HFQRSD & LAS were shortened [Article in Chinese].
Shi 1994
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320 patients with chronic hepatitis B treated with Yi-ganning Granule which contains Astragalus membranaceus showed effective recovery of liver function and 60 of 62 patients were in a stabilized state. [Article in Chinese].
Zhang 1993
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Huayu decoction which composed of Astragalus membranaceus reduced the activity of erythrocyte superoxide dismutases in 49 cases of infantile pneumonia in acute stage which returned to normal in convalescence. [Article in Chinese].
Zong 1993
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Shen-Qi (Ginseng-Astragalus) injection along with chemotherapy treatment reduced the toxic effects produced by chemical agents and increased the patient's body weight in 176 cases of malignant tumor of the digestive tract. [Article in Chinese].
Li 1992
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Pre-incubation of peripheral blood mononuclear cells separately with Astragalus membranaceus and Tripterygium hypoglaucum stimulated Natural killer cytotoxicity both in systemic lupus erythematosus patients and healthy donors. [Article in Chinese].
Zhao 1992
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Erythrocyte sodium content decreased and the sodium pump activity increased after 14 days of A. membranaceus 24 g/d i.v. in 45 coronary heart disease patients compared with 22 controls
Jin 1991
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Treatment with Kang Er Xin-I which consists of Astragalus membranaceus improved cardiac functional indexes in 26 patients & it also inactivated Coxsackie B3 virus & protected the heart cells in mice by promoting growth of interferon and by increasing the NK cell's function. [Article in Chinese].
Yan 1991
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51 cases of chronic hepatitis treated with Jiedu Yanggan Gao consisting of Astragalus membranaceus showed a total effective rate of 74.5% where as control group of 45 cases treated with 3 charred medicinal herbs had a total effective rate of 24.4%. [Article in Chinese].
Chen 1990
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Adolescent brain dysfunction improved more with TCM (Bupleurum chinense, Scutellaria baicalensis, Astragalus membranaceus, Codonopsis pilosula, Ligustrum lucidum, Lophatherum gracile & ivory thread) than with Ritalin
Zhang 1990
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Graft-versus-host reaction of mononuclear cells from 13 cancer patients increased to 151 from 57 mm3 by a fraction of Astragalus membranaceus. In rats it reversed the immunosuppressive effect of cyclophosphamide
Chu 1989
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Wen-She decoction which has 7 drugs including Astragalus membranaceus was found to be effective in controlling mild to moderate amount of acute bleeding of upper digestive tract in 7 patients.[Article in Chinese].
Gong 1989
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Astragalus membranaceus polysaccharide FB 10 micrograms/ml augmented the spontaneous 3H-TdR incorporation in the lymphocyte of 18 normal subjects from 310.2 to 910.9 counts per minute (cpm) and of 9 cancer patients from 248.5 to 642.2 cpm. [Article in Chinese].
Wang 1989b
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Using local xenogeneic graft-versus-host reaction (XGVHR) as a model assay for T-cell function, it was shown that preincubation of mononuclear cells derived from cancer patients with fraction 3 of Astragalus membranaceus induced a significant increase in local XGVHR.
Chu 1988
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[Synergism of Astragalus membranaceus with interferon in the treatment of cervical erosion and their antiviral activities].[Article in Chinese].
Qian 1987
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[Treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction.]
He 1986
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Study on the in vitro restorative effect of Astragalus membranaceus (10 microgram/ml) in 19 cancer patients and in 15 normal healthy donors showed potent immuno stimulant effect in local graft versus host reaction test assay for T-cell function.
Sun 1983
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Observational Studies/Case Reports
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[Clinical observation on effect of combined use of Astragalus and compound salviae injection in treating acute cerebral infarction][Article in Chinese].
Wu 2003
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The herbal medicines including astragalus memberanaceus (fisch) bge, codonpsis pilosual& glycyrrhiza uralensis fisch decreased the airway responsiveness of 28 asthmatic patients as revealed by increased FVC value, FEV1 and PEF compared to control.[Article in Chinese].
Wang 1998
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Left ventricular function and superoxide dismutase activity of red blood cell was increased in a study with 43 acute myocardial infarction patients
Chen 1995
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T-lymphocyte profile of peripheral blood is improved by A. membranaceus therapy in viral myocarditis patients
Huang 1995
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Angina relief was obtained with A. membranaceus in a study comparing it against nifedipine & Salvia in 92 ischemic heart disease patients
Li 1995
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Adding TCM (leaf of Asiatic Ginseng, root of Astragalus membranaceus Bge, etc) and other adjuvants to chemotherapy improved cancer survival in small cell lung cancer patients
Cha 1994
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Cardiac output increased from 5.1 to 5.9 L/min after 2 weeks Astragalus membranaceus in 20 angina patients
Lei 1994
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Chronic renal failure symptom scores was decreased from 12.5 to 5.6 in 36 patients by Baoyuan Dahuang Decoction (Panax ginseng, Astragalus membranaceus, Cassia cinnamomi, Glycyrrhiza uralensis & Rheum palmatum)
Sheng 1994
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In patients with positive ventricular late potentials, electrocardiogram was normalized in 13.6% (of 22) by Astragalus membranaceus and 12.5% (of 16) by lidocaine
Shi 1994
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320 patients with chronic hepatitis B had greater improvement with Yi-ganning (Astragalus membranaceus , Artemisia capillaris, Codonopsis pilosula, etc.) than oleanolic acid controls
Zhang 1993
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Ozone induced radicals are scavenged by Huayu (Angelica sinensis, Paeonia lactiflora, Ligusticum wallichii, Spathollobus suberectus, Hirudo nipponica, Tabanus bivittatus, Paeonia suffroticosa, Astragalus membranaceus)
Zong 1993
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Shen-Qi (Ginseng-Astragalus) reduced the toxic effects of chemotherapy in 176 cases of malignant tumor of the digestive tract, maintaining immunology parameters
Li 1992
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Campylobacter pyloridis treatment by Fu-zheng qu-xie (Astragalus membranaceus, Atractylodes macrocephala, Paeonia lactiflora, Taraxacum monogolicum & Oldenlandia diffusa)
Fang 1991
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Ventricular late potential duration was shortened by Astragalus membranaceus in a small number of patients
Shi 1991
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Cardiac functional indexes improved in 26 patients by Kang Er Xin-I (Lonicera japonica, Ophiopogon japonicus, Astragalus membranaceus mainly). It also inactivates Coxsackie B3 virus
Yan 1991
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Chronic cervicitis treatment by interferon is synergized by Astragalus membranaceus
Qian 1990
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Coronary heart disease improvement of angina (episodes reduced 90%), ischemic ST-T in ECG (56%), treadmill exercise (348 to 503 M), left ventricular function, etc, by Yi-qi Huo-xue (Ginseng, Astragalus and Angelicae Sinensis
Liao 1989
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Graft reaction was increased in 18 healthy and 9 cancer patients by Astragalus membranaceus polysaccharide extract FB
Wang 1989
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Stroke treatment with Salvia miltiorrhiza + Astragalus + Puraria
Wu 1989
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"Pharmacologic effects of codonopsis pilosula-astragalus injection in the treatment of CHD patients " (no abstract)
Liao 1988
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Changes in proteinuria, renal function and immunity after treatment with injections of a solution of Astragalus membranaceus " (Chinese, no abstract)
Dong 1987
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Synergism of Astragalus membranaceus with interferon in the treatment of cervical erosion and their antiviral activities " (chinese, clinical trial, no abstract)
Qian 1987
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"Treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction " (no abstract)
He 1986
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Local graft versus host reaction (assay for T-cell function) is restored in 9 out of 10 patients by Astragalus membranaceus extract (10 microgram/ml)
Sun 1983
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"A comparison of compositus yiqi huoxue. Huang Qi (Astragalus monogholicus Bunge) and daidzein on acute mountain sickness " (Chinese, no abstract)
Xu 1979
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"The effect of astragalus on the functional status of the liver in patients with chronic circulatory insufficiency " (Russian, no abstract)
Ponomarenko 1966
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Traditional and Folk Use
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Eight herbal products commonly used by cancer patients as complementary/ alternative medicine includes astragalus, essiac, Asian ginseng, etc.
Smith 1999
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Astragalus membranaceus, often used as a "Qi tonifier" to exert therapeutic benefit in treatment of ischemic heart disease, myocardial infarction, heart failure, and relief of anginal pain through its antioxidant activity.
Miller 1998
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Shi-Quan-Da-Bu-Tang (Ten Significant, composed of Rehmannia, Paeonia, Liqusticum, Angelica, Glycyrrhiza, Poria, Atractylodes, Panax, Astragalus membranaceus & Cinnamomum) tones the blood & vital energy, and strengthens health & immunity
Zee-Cheng 1992
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Acute upper digestive tract hemorrhage treatment with Wen-She decoction (Codonopsis, Atractylodes, Poria, Glycyrrhiza, Zingiber, Halloysitum and Astragalus membranaceus)
Gong 1989
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"On the pharmacognosy of Astragalus membranaceus Tish " (Russian, no abstract)
Nikonova 1967
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Adverse Effects & Toxicity
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Research designed to isolate and identify the active compounds present in toxic plants to livestock that graze them has been successful for many plants including Astragalus. The knowledge gained has been used to predict potential outbreaks of poisoning, and treat affected animals.
James 2004
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The ingestion of neurotoxic seeds, fruits and plants including Astragalus which are rich in swainsonine, a toxin that inhibits the enzyme alpha mannosidase can produce different neurological syndromes like locoism manifesting with cerebellar syndrome. [Article in Spanish].
Carod-Artal 2003
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Review of selenium toxicity and dietary requirement leads to a thesis that Se is a pro-oxidant and that carcinostasis benefit is related to toxicity
Spallholz 1994
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Salmonella/AFB1 mutagenic reversion assay was inhibited by Scutellaria barbata > Ligustrum lucidum > Astragalus membranaceus > Oldenlandia diffusa
Wong 1992
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Among 116 Chinese herbal formularies screened to restore immunity in cancer patients, Shi-Quan-Da-Bu-Tang which has 10 drugs including Astragalus membranaceus, was found to be most effective biological response modifier with low toxicity (LD50 > 15 g/kg op murine).
Zee-Cheng 1992
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Selenium clinical signs of weight and hair loss, cracked hooves and inflamed coronary bands were induced in all five pigs fed Na2SeO4 (26.6 ppm Se) but only one fed A. praelongus (31.6 ppm Se) and none fed A. bisulcatus (31.7 ppm Se)
Baker 1989
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Certain birth defects in livestock induced by poisonous plants such as members of the Astragalus, Lupinus, Conium, Nicotiana and Veratrum genera possess clinical similarities to congenital deformities in humans.
Keeler 1988
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"Effects of capitalized wilfordii, angelica and astragalus on glomerular permeability in rats with minimal change nephropathy " (Chinese, no abstract)
Wang 1988
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Cells affected by Astragalus lentiginosus, Swainsona galegifolia or mannosidosis show a similar lectin staining pattern, indicating accumulation of alpha-mannosyl and beta-N-acetyl glucosamine residues
Alroy 1985
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[Syndromes of astragalus poisoning in livestock.]
James 1981
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Field and experimental studies in cattle and sheep poisoned by nitro-bearing Astragalus or their toxins revealed varying degrees of alveolar emphysema in lungs and wallerian degeneration of the spinal cord.
James 1980
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Loss of condition, depression, hyperaesthesia and hyperexcitability observed in Swainsona poisoning of horses in south-western Queensland were similar to those horses suffering from Swainsona poisoning of Astragalus & Oxytropis in North America.
O'Sullivan 1977
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Animal Studies
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When different Chinese herbal medicines and western medicine were compared in treating pulmonary fibrosis in SD rats, the therapeutic effect of Radix Astragalus membranaceus was found to be lesser than that of Radix Salviae miltiorrhizae and hydrocortisone. [Article in Chinese].
Dai 2004
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Prebiotic effects of mushroom and herbal extracts including Astragalus membranaceus Radix extract were studied on chicken infected with avian Mycoplasma gallisepticum on their growth and the effect on cecal microbial ecosystem which was compared with birds treated with antibiotic Apramycin.
Guo 2004
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Sperm abnormality(SP) induced by Cadmium on rats were reverted by Astragalus membranaceus injection and showed improvement on parameters like Testis coefficient, testicular sperm count,daily sperm production & epididymal sperm count while the % of SP was also decreased.[Article inChinese]
Liang 2004
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In renal interstitial fibrosis-induced unilateral ureteral obstruction UUO rats, and angelica mixture retard the progression of renal fibrosis and renal function deterioration by inhibiting myofibroblasts and suppressing TGF-beta1 expression.[Article in Chinese]
Zhao 2004
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The baroreflex sensitivity in spontaneously hypertensive rats treated with Astragalus membranaceus was higher and there was no change in blood pressure(BP)level in these animals than the control group in which BP was increasing continuously during the observation period.[Article in Chinese]
Chen 2003
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Expression of glutathione S-transferase placenta (GST-P) protein and mRNA induced by diethylnitrosamine , two-thirds partial hepatectomy, and 2-acetylaminofluorene (DEN-PH-AAF) were reduced in rats treated with Astragalus?membranaceus, effectively delaying induced hepatocarcinogenesis.
Cui 2003
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The herbal extract of Astragalus membranaceus at 2 mg/kg/day & 10 mg/kg/day in ovariectomized rats inhibited tibia and lumbar bone loss and did not cause uterine hypertrophy but its main ingredient, 1-monolinolein did not inhibit bone loss.
Kim 2003
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A Chinese herb preparation (including Astragalus membranaceus) significantly reversed chemical-induced liver fibrosis in rats and appeared to stimulate the collagenolytic process in the liver, evidenced by an increase in urinary excretion of hydroxyproline.
Li 2003
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The water extract of Astragali (Astragalus membranaceus Bunge Radix) did not affect singly but potentiated the anti-hyperglycemic action of fangchinoline (0.3 mg/kg) from Stephania tested in streptozotocin-diabetic ddY mice.
Tsutsumi 2003
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Studies with 2 Chinese herbal preparations i)ABCI containing three herbs & ii)Qi containing R. Codonopsis Pilosulae and R. Astragalus membranaceus showed certain inhibitory effect of left ventricular remodeling in rats with left heart failure after myocardial infarction [Article in Chinese].
Wang 2002
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Among the 34 - heathy mature Japanese big-ear rabbits, with renal injury induced by ischemia reperfusion, the Astragalus Membeanaceus treated group showed low serum level of Cr & TNF-alpha and high level of bFGF in kidneys. [Article in Chinese]
Xu 2002
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Treatment of Astragalus and Angelica in rats promote the recovery of glomerular filtration rate & renal plasma flow after ischemia/
reperfusion, prevent the oliguria, reduce the increment of fractional excretion of sodium and improve the histomorphological injury of kidney. [Article in Chinese].
Sheng 2001
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Total flavonoids of Astragalus showed good protective effect against paracetamol-induced hepatic injury and caused significant reduction in paracetamol-prolonged pentobarbital-induced sleep in C57BL/6J mice. [Article in Chinese].
Wang 2001a
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Pre-treatment of total flavonoids of Astragalus (100 mg.kg-1) reduced the death rate by 20% in paracetamol-induced hepatic damaged mice.[Article in Chinese].
Wang 2001b
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The astragaloside IV inhibit the increase in microvascular permeability induced by histamine, which was expressed by changes in the transendothelial electrical resistance in pial microvessels of rat. [Article in Chinese].
Wu 2001
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Astragalus membranaceus injections increased serum Meg-CSA (megakaryocyte colony-stimulating activity) of anemic mice and accelerated the recovery of megekaryocyte hematopoiesis after bone marrow suppression.
Zhu 2001
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Astragalus?membranaceus total saponins increased the cAMP content and the total flavonids decreased the level of malondialdehyede production in the ischemic myocardium of oracotouated rats, inhibiting the production of free radicals.
Zhou 2000
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The flavonoids of Astragalus membranaceus's stem and leaves promoted the proliferation of lymphocytes induced by ConA and raised the T cell count of immunosuppressive mice.
Jiao 1999
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Hairy root of Astragalus membranaceus had similiar senility-preventing, antioxidizing and immunomodulating functions as natural A. membranaceus in a anti-ischemia-reperfusion kidney model of rat.
Jin 1999
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The effect of astragalus on the endothelin in serum and lung of the rats with acute lung injury revealed, concentration of endothelin in the lung of the rats in therapy group was lower than that of the injured rats suggesting a protective role in acute lung injury.
Liu 1999
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Astragaloside (AS) and Astragalus injections have some protective effects on myocardial injury of viral myocarditis mice.
Lu 1999
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Astragalus?membranaceus completely reversed hypothalamic arginine vasopressin (AVP) mRNA expression in both cortex and medulla of the kidney, nephrotic rat, increaseing AVP V2 receptor expressions compared with normal control rat.
Ma 1999
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Astragapolysaccharide reduces the number of antigen-induced eosinophils infiltrating into the airway of sensitized mice and inhibits the proliferation, activation of lymphocytes and IL-2 production and can be useful in the treatment of asthma.
Xue 1999
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Guinea pigs intoxicated with Dimethoate treated with glucoside extracted from the root of Astragalus Membranaceus survived longer and muscular fasciculation, fibrillation, seizures and respiratory tract secretion were significantly reduced
Li 1998
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Experimentally-induced liver fibrosis in male Wistar rats and other morphological alterations were significantly ameliorated by a Chinese medicine, Han-Dan-Gan-Le (Salvia miltorrhiza, Radix paeoniae, Astragalus membranaceus, Stephania tetrandra, and Ginkgo biloba).
Li 1998
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Survival time with dimethoate & atropine poisoning was improved with the root of Astragalus Membranaceus in guinea pigs from 70 to 235 minutes
Li 1998
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The Chinese herb, Astragalus?membranaceus, has therapeutic effects on sodium and water retention in aortocaval fistula-induced heart failure in rats.
Ma 1998
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Astragalus membranaceus decoction reduced capillary hyperpermeability and alleviated dyskinesia caused by cerebral ischemia in rats.
Quan 1998
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Coxsackievirus B3 (CVB3) was significantly reduced in Astragalus?membranaceus (AM) treated mice, especially in AM + taurine group.
Xiong 1998
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Hairy roots of Astragalus membranaceus produced by culture was found to have 5.81% & 0.14% of crude saponin and astragaloside i.v. respectively by RP-HPLC analysis and feeding with aqueous extract of the hairy roots resulted in regaining of the immunity function in rats with low immunity.
Zheng 1998
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Cerebral ischemia induced increase of thromboxane B2 was reduced by A. membranaceus i.v. in rabbits
Deng 1995
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Shi-ka-Ron, and Chinese herbs including Astragalus membranaceus resisted immunosuppression induced by antitumor agent mitomycin C in ICR mice, by stimulation of the reticuloendothelial system, activation of T cell blastogenesis and NK cell cytotoxicity [Article in Chinese].
Jin 1995
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Cyclophosphamide-induced myelosuppression was not affected by 240 mg of crude extract of Astragalus membranaceus or Ligustrum lucidum in rats
Khoo 1995
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RNA replication in myocardial tissue of mice infected with coxsackie B-3 virus is inhibited by A. membranaceus
Peng 1995
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Gentamicin ototoxicity and nephritis in guinea pigs is reduced by a compound injection Pyrola rotundifolia and Astragalus membranaceus, possibly mediated by cAMP
Xuan 1995
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Intestinal flora imbalance induced by ozone was recovered by A. membraceus root decoction in mice
Yan 1995
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IL-2 is increased in splenic lymphocytes of blood-deficient mice given Angelica sinensis or Astragalus membranaceus or Danggui Buxue decoction
Chen 1994
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Aqueous extract of Astragulus membranaceus at 50g/kg (ig) improved the anisodine-induced impairment on memory acquisition and also the alcohol-elicited deficit of memory retrieval in mice. [Article in Chinese].
Hong 1994
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Murine renal carcinoma was inhibited by Astragalus membranaceus & Ligustrum lucidum (500 micrograms each). Splenic macrophage oxidative burst activity was restored
Lau 1994
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Coxsackie virus B3 in mice is slowed by Astragalus membranaceus, possibly by inhibiting replication
Peng 1994
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In Coxsackie B3 virus infected mice survival rate and some abnormal electrophysiological parameters are improved by Astragalus membranaceus
Rui 1994
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Whole blood viscosity is decreased and plasma viscosity is increased by Astragalus membranaceus & Angelica sinensis in a blood stagnation model of rats treated with adrenaline and cold
Xue 1994
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A study on the normal rats showed that Astragalus membranaceus and tail of Angelica sinensis improved hemorrheological indexes, such as the whole blood specific viscosity[SV], the plasma SV, erythrocyte electrophoresis & had significant effects of enriching the blood. [Article in Chinese].
Xue 1993
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Scopolamine induced dysmnesia is reversed and acetylcholinesterase is inhibited in mice by Invigorating-Qi (Codonopsis pilosula, Astragalus membranaceus, Poria cocos, and Glycyrrhiza uralensis)
Liu 1993
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Coxsackie infected mice survival was increased and the percentage of abnormal action potential was lowered by Astragalus membranaceus
Rui 1993
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Phagocytosis was increased by Astragalus membranaceus (1 gm/kg/wk for 12 weeks) or exercise in mice. Superoxide anion production of peritoneal macrophages was also inceased
Sugiura 1993
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Astragalus membranaceus, a TCM for invigoration of vital energy, strengthens the movement and muscle tonus in the intestine (esp. the jejunum) of dogs
Yang 1993
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CCl4 induced liver damage in rats was reduced by YiQi Huoxue (Astragalus membranaceus, Ligusticum, Paeonia, etc)
Fu 1992
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Lymphocytes, serum IgG and thymus weight increased in mice treated with Astragalus membranaceus, Fructus Ligustri Lucidi and Eclipta prostrata for 7 days
He 1992
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There was a positive inotropic action on isolated working rat heart with Astragalus membranaceus saponins 50-200 micrograms/ml but it is negative at a lower dose
Wang 1992
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GSH and survival of endotoxin treated mice was increased by Astragalus polysaccharide (30, 60, 100 mg.kg-1.d-1 x 7d, ip) dose-dependently
Wang 1992
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Collagen in the aorta and lung of old rats is kept lower by Astragalus root
Xu 1991
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Burn induced reduction of cell mediated immunity is restored somewhat by cerium with Astragalus membranaceus or Lonicera japonica in mice
Luo 1990
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Astragalus Membranaceus was found to be effective in the inhibition of Coxsackie B virus propagation and protection of myocardium in 4-week-old male BALB/C mice myocarditis.
Yang 1990
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Coxsackie B-2 virus infected rat heart cells are somewhat protected by Astragalus membranaceus
Yuan 1990
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Stilbenemidine induced liver injury was alleviated by Astragalus membranaceus root ethanol extract fed mice
Zhang 1990
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Qi-Xue (Panax ginseng, Astragalus monogholicus, Angelica sinensis) or verapamil minimized the increase in pulmonary arterial pressure due to hypoxia in rats
Zhao 1990
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Immunodepression by age, cyclophosphamide or radiation is reversed by Astragalus membranaceus extracts injection in mice
Zhao 1990
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Lipid peroxidation was inhibited in vitro and lipofuscin of liver and brain tissues was reduced in mice fed Shou Xing Bu Zhi (Polygonum multiflorum, Codonopsis silvestris, Astragalus membranaceus, Poria cocos, etc.) 10 g/kg/d for 3 months
Chen 1989
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Large dose of Yang-restoring herb medicines which includes Astragalus membranaceus, reduced natural weight gain, decreased serum T3 level, raised rT3 & TRH levels and TSH showed a raising tendency in normal rats. [Article in Chinese].
Chen 1989
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The effects of vitamin A and Astargalus on the splenic TL-CFU of mice were studied by means of T-lymphocytes colony formation in semi-solid culture in vitro& incorporation of 3H-TdR. [Article in Chinese].
Pang 1989
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Antitumor polysaccharide from Astragalus or Radix hedysarum at 500 mg/kg enhanced the third component of complement (C3) cleavage production of macrophages in ICR mouse as shown by immunofluorescent method.
Wang 1989
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Thymus index, spleen index, humoral immunity and cell mediated immunity are promoted in hungry mice by Codonopsis pilosulae and Astragalus injection
Zhou 1989
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Abrogation of graft versus host reaction, maximally by injection of 5.55 mg/d of fraction F3 (MW 20-25 kd) for 8 days in rats, indicates a reversal of the immunosuppressive effect of cyclophosphamide
Chu 1988
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[Effects of capitalized wilfordii, angelica and astragalus on glomerular permeability in rats with minimal change nephropathy].[Article in Chinese].
Wang 1988
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"Effects of Crataegus pinnatifidae, Astragalus memoranaceus and Acanthopanax senticosus on cholesterol metabolism in the guinea pig " (Chinese, no abstract)
Wang 1987
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"Pharmacological action of Astragalus membranaceus on the central nervous system in mice " (Chinese, no abstract)
Pan 1986
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Tetracycline liver toxicity is reduced by vitamin E, sodium selenite or Astragalus, which decrease lipid peroxidation in rats
Skakun 1984
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"Effects of Astragalus membranaceus on enhancement of mouse natural killer cell activity " (Chinese, no abstract)
Chang 1983
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The use of vitamin E combinations with selenium-containing preparations or Astragalus L. infusion markedly or completely arrested the occurrence of hepatotoxic properties of tetracycline on albino rats. [Article in Russian].
Skakun 1983
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"Preliminary observation on the therapeutic effect of Astragalus membranaceus in experimental anti-glomerular basement membrane nephritis in rabbits " (Chinese, no abstract)
Zhao 1983
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"In vitro effect of Astragalus mongholicus on activity of cyclic nucleotide phosphodiesterases (cAMP-PDE) in liver and spleen cells of mice " (Chinese, no abstract)
Liu 1982
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"Effect of Astragalus polysaccharides on phagocytic function in mice " (Chinese, no abstract)
Chen 1981
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"A pharmacological study on Astragalus membranceous root--effect on the irritable state in rats " (Chinese, no abstract)
Song 1981
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Pharmacodynamics
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The investigation of in vitro fermentabilities of two mushrooms, Astragalus membranaceus and their polysaccharide fractions (LenE, TreE, and AstE) using microflora from chicken ceca show promise in altering microbial activities and composition.
Guo 2003
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The four compounds Formononetin , 9Z,12Z-octadecadienoic acid , stigmast-4-en-6beta-ol-3-one and 98-E isolated from extracts of Astragalus membranaceus Radix induced growth hormone release in the rat pituitary cell culture and among these 98-E was found to be the most active.
Kim 2003b
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Astragalus membranaceus and Angelica sinensis in 5:1 ratio have certain promotive effect on the formation of capillary (angiogenesis effect) in chick embryo choriollantoic membrane.[Article in Chinese]
Lei 2003a
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Astragalus membranaceus and Angelica sinensis promote vascular endothelial cell proliferation, DNA synthesis, and exhibit synergistic effect when used in combination. [Article in Chinese]
Lei 2003b
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[The effects of endotoxin on the Th1/Th2 cells and immune modulation of Astragalus membranaceus. [Article in Chinese]
Liu 2003a
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Among the 15 extracts from traditional Chinese medicinal plants used to treat topical inflammations, Astragalus membranaceus inhibited 5-lipoxygenase, with IC50 values of 141 microg mL(-1).
Prieto 2003
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Astragali radix extract blocked the effect of interleukin -1beta in leukotriene C(4) production in human amnion, thus exhibited a broad antiinflammatory effect and used as a promising agent to protect preterm labour.
Shon 2003
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The two isomers HDTIC-1 and HDTIC-2 from Astragalus membranceus, maintain non-senescent phenotype of human fetal lung diploid fibroblast (2BS cells) even at late population doubling.
Wang 2003
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The saponin astragaloside IV from the Chinese medical herb Astragalus membranaceus, inhibits the NF-kappaB pathway, thus exhibit anti-inflammatory potential in vivo.
Zhang 2003c
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Equiguard, a herbal preparation containing 9 herbs including Astragalus membranaceus is found to be efficacious in preventing or treating both androgen-dependent and independent prostate carcinoma as it is capable of targeting multiple signal transduction / metabolic pathways of cancer cells.
Hsieh 2002
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The screening of 18 Chinese medical plant extracts including Astragalus membranaceus against epimastigote of Trypanosoma cruzi Bra C15C2 clone in vitro at 250 microg/ml in axenic culture showed 20-100% of growth inhibition.
Schinella 2002
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Astragalus membranaceus extract promote the proliferation of human peripheral blood mononuclear cells, elevate the tumor cell-killing activity of cytotoxic T-lymphocyte, etc thus enhancing the human immuno-function in vitro.[Article in Chinese]
Wang 2002a
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Astragalus injection at 62.5-250 micrograms/ml promote rat's small intestinal crypt-like cell line (IEC-6) differentiation by means of inducing the ornithine decarboxylase activity and biosynthesis of polyamine. [Article in Chinese].
Zhang 2002
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Danggui Buxue Decoction comprising Angelica sinensis and Astragalus membranaceus promoted the proliferation of human umbilical vein endothelial cells and increased the expression of intercellular adhesion molecule-1. [Article in Chinese].
Wu 2001b
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Studies on the protective effects of radix astragali against anoxic damages to in vitro cultured neurons in rats by using NaCN as hypoxic model from newborn rat cerebral cortex revealed the mophological changes were mild, the effluxes of LDH & K+ were decreased & A value increased.
He 2000
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These results demonstrated that Astragali Radix has inhibitory effects on oxidative stress induced by metal.
Toda 2000
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A formulation of Polygonum multiflorum, Angelica sinensis and Astragalus membranaceus appear to sustain the myocardial glutathione antioxidant status under conditions of IR-induced oxidative stress
Yim 2000
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Astragalus membranaceus injection 40 microgms/ml & 400 microgms/ml in culture system, promoted normal murine bone marrow cells (BMC) and anemic murine BMC respectively. [Article in Chinese].
Zhu 2000
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Of 28 extracts, melanocyte proliferation was stimulated by aqueous extracts of Astragalus membranaceous root, Citrus peel, Dictamnus dasycarpus root bark. Ophiopogon japonicus root, Poria cocos sclerotium & Tribulus terrestris fruit
Lin 1999
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Clinical studies with Astragalus membranaceus, a Chinese herb, have indicated that its in vitro antioxidant activity is the mechanism by which it affords its cardioprotective benefit.
Miller 1998
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The anti-herpes simplex virus activities of suppository and ointment combining Astragalus?membranaceus and ecombinant human interferon alpha 2b(IFN) were shown to be significantly higher than that of IFN alone.
Zhang 1998
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