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SCIENTIFIC NAME:
Pausinystalia yohimbe
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FAMILY NAME:
Rubiaceae
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COMMON NAME:
yohimbe, johimbe
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History of Records
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History of Record (1)
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BACK TO HOME
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| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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Clinical Trials
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Yohimbine has been evaluated in the management of erectile disorder by means of placebo-controlled
but often poorly designed trials. It does appear to have a modest therapeutic benefit over placebo, particularly in essentially psychogenic erectile disorder.
Riley 1994
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Adverse Effects & Toxicity
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A severe case of intractable priapism associated with the ingestion of yohimbe extract has been reported; management required insertion of a proximal cavernosal spongiosum shunt (Quackles shunt) in the operating room.
Myers 2009
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A study of the effect of Corynanthe yohimbe on germ cells in Swiss albino mice applying reproductive, cytological and biochemical parameters showed decrease in male fertility, abnormalities
and chromosomal aberrations of spermatozoa and changes in biochemical parameters.
Al-Majed 2006
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Clinical evidence on adverse events of herbal food supplements for body weight reduction, including Pausinystalia yohimbe, for which effectiveness data from rigorous clinical trials exist were assessed.
Pittler 2005
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Interactions
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A review on herb-drug interactions revealed plausible cases including increased risk of hypertension when tricyclic antidepressants are combined with yohimbine (Pausinystalia yohimbe).
Fugh-Berman 2000
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Animal Studies
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By mapping the distribution volume of
[(11)C]mirtazapine (a ligand for PET studies of antidepressant binding) in porcine living brain, study showed that alpha(2)-adrenoceptor blockers yohimbine and RX 821002 caused a decrease in [(11)C]mirtazapine pB throughout the forebrain.
Smith 2006
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A study on aqueous extract of Pausinystalia yohimbe (CCD-X) on vascular and renal regional hemodynamics in Sprague Dawley rats revealed that CCD-X possesses endothelin-like actions and affects nitric oxide production in renal circulation.
Ajayi 2003
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Analytical Chemistry
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Qualitative and quantitative analysis of Pausinystalia yohimbe-type alkaloids in the barks of Rubiaceae species was done using analytical approaches like GC-MS & non-aqueous CE (NACE) with diode array detection. The recovery of yohimbine was 91.2-94.0% with RSD 1.4-4.3%.
Chen 2008
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Fourier transform infrared rays and X-ray photoelectron spectroscopy analysis revealed that both sorbents from grape stalks and yohimbe bark wastes were able to reduce Cr(VI) to its trivalent form from aqueous solutions.
Fiol 2008
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A rapid qualitative and quantitative method based on an HPLC-UV-MS technique with atmospheric pressure chemical ionization and electrospray ionization for the analysis of yohimbine in authentic yohimbe bark in a number of commercial aphrodisiac products is reported.
Zanolari 2003
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A method for extraction and capillary gas chromatographic separation of the alkaloids of P. yohimbe was developed and used to analyze a number of commercial yohimbe products.
Betz 1995
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A study of the alkaloid content of trunk-barks of Pausinystalia macroceras resulted in isolation of six alkaloids, five of which are indole alkaloids that belong to the yohimbane and heteroyohimbane groups; yohimbine was found in large amount.
Leb?uf 1981
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Patents
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As a component to promote blood circulation in a composition for topical application to an animal's skin for relief from a variety of symptoms caused by medical conditions or physical injuries
US patent 6,579,543
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A lubricating composition for use in mucosal areas is provided to enhance sexual performance.
US patent 6,428,791
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Describes novel compositions comprising alpha-adrenergic receptor antagonists and compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, or stimulate nitric oxide synthesis useful for treating impotence in males and females.
US patent 6,294,517
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Describes methods for preventing and treating sexual dysfunctions in patients by orally administering at least one .alpha.-adrenergic receptor antagonist (preferably yohimbine) and at least one compound that elevates endogenous nitric oxide or endothelium-derived relaxing factor in vivo.
US patent 6,323,211
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A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof, or effective .alpha..sub.2 -antagonists, skin for inhibiting melanogenesis in the skin leading to skin lightening.
US patent 6,110,448
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Conduct a search for "johimbe" or "yohimbe" in the title, abstract or claims section of the
US patent database
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Related Links
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Taxonomic information for P. johimbe at USDA's Germplasm Resources Information Network
(GRIN)
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Patient Education Monograph of Pausinystalia yohimbe prepared by J. Iverson Riddle Developmental Center
(JIRDC)
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Taxonomic family (Rubiaceae) descriptions, illustrations, identification, and information retrieval by L. Watson and M. J. Dallwitz from the
DELTA DB
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Basic information and links to other information sources
Erowid
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Brief monograph on yohimbe bark extract with references edited and peer-reviewed by contributors to the Natural Standard Research Collaboration
MedLine Plus
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Report on yohimbe prepared by Technical Resources International for the Chemical Selection Working Group of the
National Toxicology Program
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Entry in "A Nurse's Guide to Herbal Remedies" from Salisbury University
Nursing Guide
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