| |
SCIENTIFIC NAME:
Aconitum sp.
|
FAMILY NAME:
Ranunculaceae
|
COMMON NAME:
Monkshood, Wolfsbane, Blue Rocket, Friars Cap, Mousebane
|
 |
|
|
|
|
|
|
|
|
|
|
|
| |
|
|
| |
 |
 |
 |
| EVIDENCE FOR EFFICACY (HUMAN DATA) |
|
| |
|
Clinical Trials
|
 |
Anxiety was treated with Aconite 200CH in nine patients, Opium 200CH in three, Ignatia 200CH in two and Arsenicum album 200CH in one according to type of anxiety. One day later, most patients reported a lessening of pain & 89% had reduced anxiety.
Oberbaum 2003
|
|
| |
A double-blind clinical trial of Aconite in 50 children with post-operative pain & agitation shows it was effective for children's postoperative agitation with 95% good results & it is an amazing cure when well prescribed, as much for speediness of its action & its efficiency. [Article in French]
Alibeu 1990
|
|
| |
[Use of muscle relaxants of the aconite group in the treatment of fractures and fractures-dislocations of the bones of the limbs by the method of continuous traction] [Article in Russian]
Gorlianskiĭ 1975
|
|
| |
[Cardiovascular aspects of aconite poisoning in human beings.]
Kapoor 1969
|
|
| |
[Use of muscle relaxants of the aconite group in the treatment of fractures of long tubular bones by the constant traction method] [Article in Russian]
Pashchuk 1969
|
|
| |
[Aconite-induced ventricular tachycardia during radiation sickness.] [Article in French]
Jurkovic 1962
|
|
| |
[Aconite-induced ventricular tachycardia during radiation sickness.] [Article in French]
Jurkovic 1962a
|
|
| |
[Medicinal and poisonous plants. VII. Aconitum napellus.] [Article in Danish]
Larsen 1962
|
|
|
Observational Studies/Case Reports
|
| |
An autopsy case had been gradually revealed to be a murder using aconite poisons. Technical methods have been developed using GC/MS and LC/MS for the quantification of the toxins in biological materials. [Article in Japanese]
Ohno 2006
|
|
| |
[Poisoning with Aconitum napellus (monkshood)] Article in Danish]
S?en 2003
|
|
| |
A 40-year-old woman in Japan, ingested ground aconite and died of aconite intoxication about 4h after ingestion. The Aconitum alkaloids were quantitated using gas chromatography-selected ion monitoring from extracts of the body fluids and organs.
Ito 2000
|
|
| |
A case of self-medication with 'tincture of aconite' resulting in severe bradycardia, reversible panconduction defect evidenced by sinus inactivity, atrioventricular dissociation with idiojunctional rhythm and left bundle branch block pattern resulting in hypotension and syncope was reported.
Guha 1999
|
|
| |
[Sustained ventricular tachycardia in a case of aconite poisoning.]
Gupta 1999
|
|
| |
A 45-year-old male attempted suicide by oral intake of Aconitumalkaloids, which are highly intoxicant extracts of Aconitum tubers was reported & it was estimated that he had ingested approximately 11 mg of diesterditerpene-type alkaloids but was saved by intensive gastric irrigation.
Mizugaki 1998
|
|
| |
A 61-year-old man developed symptoms of nausea, diarrhea, and discomfort of the body about 2h after the ingestion of aconite and the patient fell into a coma and died of brain edema diagnosed by CT on the 6th day.
Yoshioka 1996
|
|
|
|
| |
Aconite is a Chinese herb used as an analgesic by homeopaths; its chief effects are on the cardiovascular and central nervous systems. The first two reported cases of aconite poisoning in Australia are described.
Fatovich 1992
|
|
| |
Both aconite toxins (aconitine, mesaconitine, and hypaconitine) and a pufferfish toxin (tetrodotoxin, TTX) were detected in the blood of a legal autopsy case and it is thought that the toxic effects of aconitine are attenuated by TTX in vivo.
Ohno 1992
|
|
| |
The clinical, electrocardiographic, and electropharmacological characteristics of an unusual case of bidirectional tachycardia induced by aconites present in a Chinese herbal decoction consumed by a previously healthy subject was reported in detail.
Tai 1992
|
|
| |
A case of fatal intoxication caused by aconite monk's hood (Aconitum napellus) in a 20 month old child was reported. [Article in German]
Feldkamp 1991
|
|
|
|
| |
A case of homicidal poisoning by aconite is reported and Jesaconitine was detected in the vomitus, stomach contents, plasma and urine at concentrations of 32.2, 5.48, 0.433 and 1.07 micrograms/ml,respectively. [Article in Japanese]
Mori 1990
|
|
|
|
| |
[Aconite: a case study in doctrinal conflict and the meaning of scientific medicine.]
Haller 1984
|
|
| |
[Case of poisoning with aconite tincture] [Article in Russian]
Kuropov 1983
|
|
| |
[Malignant Arrhythmias Induced by Accidental Aconite Poisoning.]
Agarwal 1977
|
|
| |
[Clinical course and treatment of aconite tincture poisoning] [Article in Russian]
Gizamullin 1976
|
|
| |
[2 cases of acute peroral poisoning with aconite] [Article in Russian]
Leshchenko 1975
|
|
| |
[A case of successful resuscitation of a patient after aconite root poisoning] [Article in Russian]
Ganzha 1970
|
|
| |
[A case of aconitine poisoning with cardiac symptoms.] [Article in French]
Dechelotte 1964
|
|
| |
[Aconite poisoning and cardiac arrhythmias: report of 3 cases.]
Merchant 1963
|
|
| |
[Curious case of fatal poisoning caused by aconite.] [Article in French]
Colson 1956
|
|
|
Traditional and Folk Use
|
| |
A general anesthetic called " foamy narcotic powder" thought to contain datura flower, aconite root, rhododendron flower, or jasmine root was used for surgery by Hwa Tuo, the most famous doctor in china, in the second century. [Article in Chinese]
Chu 2004
|
|
| |
The herbal drug Aconite described by Nicander of Colophon (IInd century BC) is studied as to its symptoms and uses. [Article in French]
Skaltsa 1997
|
|
| |
Review on the search for selective anti-anxiety agents indicates that the 1860s, cardioactive drugs such as atropine, aconite, and digitalis were assumed to counteract anxiety because it could be associated with tachycardia and/or melancholia.
Estes 1995
|
|
| |
Poisonous plants including aconite, ergot, Euphorbiaceae/Thymelaeaceae, curare, cardiac glycosides, triterpenoid saponins and animal toxins are widespread in nature and have been used for a great variety of purposes.
Bisset 1991
|
|
| |
A review on the botany of Chinese Aconitum species indicates that 5 species including A. carmichaelii, A. nagarum, & A. stylosum, etc. have been identified as sources of arrow poison.
Bisset 1981
|
|
| |
Discussion on the hunting poisons of the North Pacific region indicates that the most important one used by the Ainu was based on Aconitum species (surku or suruku): on Hokkaido, to some extent A. japonicum Thumb.
Bisset 1976
|
|
|
|
|
|
|
|
|
|
| |
[On a monodemethylacontine.] [Article in French]
Bellet 1960
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Monograph in "A Modern Herbal" by Mrs. M. Grieve at
botanical.com
|
|
|
|
|
Adverse Effects & Toxicity
|
| |
The Toxicology Reference Laboratory, Hong Kong, has confirmed 10 cases of aconite poisoning from March 2004 to May 2006.
Poon 2006
|
|
| |
Documentation of the large variety of dangerous poisons readily available on a popular online auction Web site shows that among 121, 63 products contained "extremely toxic" ingredients including plant extracts of gelsemium & aconite.
Cantrell 2005
|
|
| |
The clinical problems arising from the use of herbal medicines included the Aristolochia species causing acute renal failure & aconite roots causing aconitine poisoning.
Chan 2005
|
|
| |
[Herbal aconite tea and refractory ventricular tachycardia.]
Lowe 2005
|
|
| |
[Bidirectional ventricular tachycardia resulting from herbal aconite poisoning.]
Smith 2005
|
|
| |
Life-threatening ventricular tachycardia can occur after the consumption of aconite roots. The risk is higher with inadequately processed aconite roots, large doses, or tincture preparations.
Lin 2004
|
|
| |
The cardiovascular adverse effects of herbal medicines that have been implicated repeatedly include aconite, ephedra and licorice.
Ernst 2003
|
|
| |
The number of hospitalisations due to aconitine poisoning markedly decreased from 4 to 6/year in 1989 to 1991 to 1 to 2/year in 1992 to 1993. Publicity measures to promote awareness, among the herbalists and the public, may reduce the incidence of poisoning due to toxic herbs such as aconite roots.
Chan 2002
|
|
| |
A case of poisoning from Aconitum napellus, ingested by a husband and wife who thought the plant was "mountain chicory" was reported and both had tachyarrhythmias and respiratory paralysis. [Article in Italian]
Gaibazzi 2002
|
|
| |
The safety of bayacon, a new drug based on Baikal aconite intended for the treatment of inflammation-proliferative dermatitis (psoriasis), was studied and with respect to a single introduction in rats and mice, the drug is classified as a low-toxicity substance. [Article in Russian]
Karpova 2002
|
|
| |
Review on the diagnosis and management of uncommon poisonings includes alkaloids (e.g. mushroom, aconite, conium) and cantharidin poisoning along with the miscellaneous poisonings of quinine, chloroquine, isoniazid, thyroxine, etc.
Worthley 2002
|
|
| |
[Aconite, poison and drug, sprung from the slaver of Cerberus] [Article in French]
Haas 1999
|
|
| |
In 3 fatal cases of tachyarrhythmia caused by herbal poisoning, the only common denominator was the presence of aconites derived from the rootstocks and lateral root-tubers of Aconitum carmichaeli and the rootstocks of A kusnexoffii.
But 1994
|
|
|
|
| |
[Hemosorption in the combination therapy of acute aconite poisoning] [Article in Russian]
Togaĭbaev 1993
|
|
| |
Life-threatening intoxication has been documented in 17 Chinese subjects after accidental herb-induced aconite poisoning. All patients developed symptoms of aconite toxicity and most developed tachyarrhythmias, including ventricular tachycardia.
Tai 1992
|
|
| |
[Ayurvedic drugs--no more innocent (cardiotoxic aconite)]
Gohel 1991
|
|
| |
Crude aconite was found to be significantly toxic to mice (100% mortality at a dose of 2.6 mg/mouse) whereas the fully processed aconite which undergoes 'samskaras' before being utilised in the Ayurvedic formulations, was absolutely non-toxic.
Thorat 1991
|
|
| |
[Aconite induced reversible ventricular dysrrhythmia.]
Sharma 1990
|
|
| |
[Aconite intoxication and cardiac arrhythmias.]
Gohel 1989
|
|
| |
[Play it again, Voltaire--aconite (Monkshood) poisoning.]
Mack 1985
|
|
| |
[Prevention and treatment of aconite poisoning] [Article in Chinese]
Yang 1985
|
|
| |
[Imported Bupleurum contaminated with Aconite] [Article in Japanese]
Natori 1974
|
|
|
|
|
|
| |
[Recovery in aconite poisoning by intravenous administration of calcium gluconate and magnesium sulfate.] [Article in Dutch]
Begemann 1961
|
|
| |
[Recovery from poisoning by aconitine nitrate due to a habitually fatal dose.] [Article in French]
Molimard 1960
|
|
|
Animal Studies
|
| |
Shenfu (ginseng and aconite root) injection can enhance the physical development and elevate the survival rate of neonatal rats with hypoxic-ischemia (HI) insult, and significantly prevents apoptosis of the hippocampus neurons from HI insult. [Article in Chinese]
Wang 2006
|
|
| |
It is demonstrated that the high muscarinic and high beta 1-adrenergic sensitive mice may be stratified into two groups based upon an antagonistic interaction between higenamine and aconitine.
Kimura 1995b
|
|
| |
Administration of Tinctura aconiti (0.6 mg of total alkaloid/kg 2x) intraperitoneally in rabbits to evaluate its toxic effects on the visual system suggests that aconite may cause primarily myelo-optic neuropathy. that aconite may cause primarily myelo-optic neuropathy.
Suk 1994
|
|
| |
Intraperitoneal administration of a single dose of aconitine (0.6 mg/kg), the principal constituent of aconite, in a rabbit model suggests that a toxic dose of aconitine may cause myelo-optic neuropathy in rabbits.
Kim 1991
|
|
| |
8 pyro-type aconitine alkaloids(AA) contained in aconite powder 'Kako-bushi-matsu' were studied for analgesic, antiinflammatory & acute toxic actions. The analgesic activity of pyro-type aconitine alkaloids was lower than that of each of parent AA, mesaconitine, hypaconitine & jesaconitine.
Murayama 1991
|
|
| |
The analgesic effect and acute toxicity of a medical drug "kako-bushi-matsu" (S-01), which was produced through several processing of raw aconite roots, were examined in comparison with those of ibuprofen, indomethacin and aspirin in animal models. [Article in Japanese]
Murayama 1989
|
|
| |
[Comparison of cardiovascular effects of aconite root and higenamine in dogs (author's transl)] [Article in Chinese]
Huang 1980
|
|
| |
[Emetic effect of apomorphine, morphine and aconitine injected into different parts of brain.]
Grechishkin 1964
|
|
| |
[Emetic effect of apomorphine, morphine and aconitine in various modes of administration.] [Article in Russian]
Grechishkin 1963
|
|
| |
[Mechanism of atrial flutter and fibrillation induced by aconitine in the dog, with observations on the role of cholinegic factors.]
Sharma 1963
|
|
| |
[Studies on aconitine-induced atrial fibrillation of the young rabbit by the microelectode technic.] [Article in Japanese]
Yanaga 1961
|
|
| |
[Studies on aconitine-induced auricular fibrillation of the young rabbit by the microelectrode technic.] [Article in Japanese]
Yanaga 1961a
|
|
|
Pharmacodynamics
|
| |
It is demonstrated that disruption of intracellular Ca(2+) homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic cytotoxicity in aconitine-induced cardiomyocytes.
Fu 2007
|
|
| |
It is found that (S)-higenamine, an active ingredient of Aconite tuber, may be more beneficial than (R)-enantiomer in diseases associated with iNOS over-expression, such as septic shock.
Park 2006
|
|
| |
Shenfu (red ginseng and aconite root) injection has protective effect on ischemia-reperfusion injury of rat liver graft. It inhibits the production of oxygen free radical and the activation of Kupffer cells, decreases apoptosis of liver cell, and improves microcirculation.
Zhu 2006
|
|
| |
Decoction for resuscitation & its component herbs incl. aconite root extract, extracts of aconite root & prepared licorice root, increased the content of 6-keto-PGF1alpha/TXB2 but had no effect on TXB2 content in culture medium of rat vascular endothelial cells under hypoxia. [Article in Chinese]
Liu 2004
|
|
| |
Mesaconitine, an aconite alkaloid, stimulated Ca(2+) influx via the Na(+)/Ca(2+) exchangers in endothelial cells and caused relaxation in the aorta.
Ogura 2004
|
|
| |
Shenfu Injection (ginesenoside and aconite alkaloid) can depress the apoptosis of intestinal mucosal epithelial cells during ischemia-reperfusion by restraining expression of TNF-alpha, Fas, caspase-3 & accordingly alleviate ischemia and reperfusion injury of intestinal mucosal epithelial cells.
Xia 2004
|
|
| |
It is suggested that mesaconitine, an alkaloid from Aconitum japonicum, elicits vasorelaxation of isolated rat small gastric artery mainly via release of endothelium-derived hyperpolarizing factor.
Mitamura 2002
|
|
| |
The vasorelaxation effects of mesaconitine, one of the aconite alkaloids in Aconiti tuber, on the contraction and free intracellular Ca2+ concentration ([Ca2+]i) level in isolated rat thoracic aorta was investigated.
Mitamura 2002a
|
|
| |
Studies conducted on mouse phrenic nerve-diaphragm muscle preparation revealed that among 2 components contained in aconite root, higenamine increases acetylcholine(ACh) release via activation of beta-adrenoceptor & conversely coryneine depresses ACh release by acting at motor nerve terminal.
Nojima 2000
|
|
| |
The higenamine, an active component of aconite root, inhibits inducible nitric oxide (NO) synthase expression by inhibiting nuclear factor kappaB activation by LPS + IFN-gamma, which may be beneficial in inflammatory diseases in which enhanced formation of NO is the main causative factor.
Kang 1999
|
|
| |
It is suggested that the potentiating interaction between aconitine and higenamine, the major cardioactive compounds from processed aconite, involves "cross-talk" between the beta 1-adrenergic signalling pathway and Gi-protein.
Kimura 1996
|
|
| |
It is indicated that the cortical acetylcholine (ACh) release caused by peripherally administered aconitine does not occur through activation of the central muscarine receptor, and thus its ACh release may not be concerned with the occurrence of bradycardia.
Kimura 1996a
|
|
| |
High levels of corticosterone (CS) increase macrophage response to ifn-gamma on Ia antigen expression & low levels of CS decrease it. Aconite extract & aconitine stimulate the response to IFN-gamma-activated expression of Ia antigen by macrophages caused by increasing plasma CS level.
Kimura 1995
|
|
| |
The influence of cholera toxin, a Gs-protein activator, and pertussis toxin, a Gi-protein inhibitor on the chronotropic interaction between higenamine and a muscarinic agonist, acetylcholine in the isolated right atria of mice have been investigated.
Kimura 1995a
|
|
| |
Investigation of the mode of the neuromuscular blocking action of coryneine derived from aconite root in isolated phrenic nerve-diaphragm muscles and denervated diaphragm muscles of mice shows that it is a mixed-type competitive and noncompetitive neuromuscular blocker.
Kimura 1995b
|
|
| |
It is indicated that higenamine, a component of aconite root, is a beta 1-adrenoceptor full agonist in murine atria and that the aconitine-induced tachyarrhythmia is augmented by the beta 1-adrenergic action of higenamine.
Kimura 1994
|
|
| |
The magnitude of the analgesic therapeutic indices of 3, 15-Diacetylbenzoylaconine (Dia), 3-acetylaconitine (Ace) and aconitine (Aco) in the algo-model were in the order of Dia > Ace > Aco. [Article in Chinese]
Zheng 1994
|
|
| |
The biochemical properties of the lectin from Eranthis hyemalis (winter aconite) was characterized and demonstrated that it possesses the property of inhibition of protein synthesis using in vitro eukaryotic translation systems.
Kumar 1993
|
|
| |
(+/-)-Higenamine (demethylcoclaurine) is a cardiotonic principle from aconite root and it shows positive inotropic effects in papillary muscles of guinea pigs.
Kimura 1989
|
|
|
|
| |
[Letter: Studies on cardiac principle of aconite root.]
Kosuge 1976
|
|
| |
[Role of Nodose ganglion in vomiting reflex to aconitine and veratrine.]
Bobkov 1965
|
|
| |
[The effect of aconitine on the giant axon of the squid.]
Herzog 1964
|
|
| |
[Influence of autonomic blockade on aconitine induced pulmonary edema.]
Wood 1964
|
|
| |
[Studies on aconitine-induced ventricular fibrillation by simultaneous recording of electrocardiograms and transmembrane potentials in situ.]
Yanaga 1964
|
|
| |
[Studies on the appearance and termination of aconitine-induced atrial fibrillation with microelectrodes.]
Goto 1963
|
|
| |
[The effect of aconitine, adrenalin and procaine, and changes in the ionic concentration in the production of ventricular fibrillation in a hibernator (hedgehog) and a non-hibernator (guinea-pig) at different temperatures.]
Johansson 1963
|
|
| |
[Electrophysiological studies on the effect of quinidine on aconitine poisoning of myocardial fibers.] [Article in German]
Heistracher 1962
|
|
| |
[The action of dichloroisoproterenol (DCI) and several other pharmacological agents upon the aconitine-induced ventricular arrhythmia in the isolated rabbit heart.]
Lucchesi 1962
|
|
| |
[On the transmission of excitation in the atrial muscle during aconitine-induced fibrillation.]
Tamai 1961
|
|
| |
[Experiments with aconitine on the problem of spontaneous stimulus formation in the heart.] [Article in German]
Schmidt 1960
|
|
| |
[Action of aconitine and procaine amide on isolated mammalian auricles.] [Article in Italian]
Sorrentino 1959
|
|
| |
[Mitigation of aconite; a preliminary note.]
Handa 1951
|
|
|
Analytical Chemistry
|
| |
ESI-MS spectrometric method was established to study the influence of different herbal combination with Radix Aconiti in traditional medical formulation(TMF) on content of aconite alkaloids, for elucidating the scientific basis of reducing the toxicity of aconite in TMF. [Article in Chinese]
Yue 2007
|
|
| |
A sensitive LC-MS-MS method was developed & employed in the urine analysis of a 55-year-old male who died after ingestion of aconite root powder. Yunaconitine, crassicauline A and foresaconitine were identified in the urine.
Zhaohongwang 2007
|
|
| |
Using a triple-quadruple tandem mass spectrometer, a group screening method was developed based on the mass-fragmentographic scheme of common aconitum alkaloids. This method is an important diagnostic aid for acute poisoning by aconites of an unclear origin.
Lai 2006
|
|
| |
Three pairs of isomers of aconite alkaloids from Aconitum nagarum var. lasiandrum were investigated by electrospray ionization mass spectrometry and tandem mass spectrometry employing ion-trap and quadrupole time-of-flight mass spectrometers.
Li 2006
|
|
| |
A reliable, reproducible and accurate modified RP-HPLC method was developed for the quantitative determination of all three Aconitum alkaloids, aconitine, mesaconitine and hypaconitine.
Jiang 2005
|
|
| |
Quantitative analysis of the six Aconitum alkaloids in the unprocessed aconite roots and in twelve proprietary Chinese medicines containing processed aconite roots by HPLC method showed that the contents of the alkaloids varied significantly.
Xie 2005
|
|
| |
In two fatal cases with suspected aconite intoxication, aconitine could be detected in blood samples at concentrations of 10.0 and 12.1 ng/g by using liquid chromatography-tandem mass spectrometry.
Beike 2004
|
|
| |
[Total synthesis of (+/-)-nominine, a heptacyclic hetisine-type aconite alkaloid.]
Muratake 2004
|
|
| |
Capillary electrophoresis-mass spectrometry was applied to the determination of alkaloids in Maqianzi and Wutou (aconite root, Radix aconiti praeparata) during the analysis of chinese medicines preparation.
Feng 2003
|
|
| |
Nordeterpenoid alkaloids in the crude aconite roots, the decoction of crude aconite roots and aconite roots were analyzed and compared with some other Chinese traditional herbs by electrospray ionization trap tandem mass spectrometry. [Article in Chinese]
Wang 2003
|
|
| |
The alkaloids in processed aconite tuber of Aconitum Carmiechaeli were studied, and five novel alkaloids in extract from processed aconite tuber were found. Based on their multi-stage tandem mass spectrometry, structures of the five novel compounds were elucidated.
Xu 2003
|
|
| |
A rapid, specific and precise HPLC method was developed to evaluate the quality of the pesticide, for the separation and quantitation of alkaloids in the aconite extract and the mixed products (the aconite extract is mixed with emulsion). [Article in Chinese]
Chen 2002
|
|
| |
The analytical findings in a recent death in the UK, resulting from deliberate ingestion of Aconitum napellus extract was described. The concentrations of aconitine measured by HPLC-DAD in the post mortem femoral blood and urine were 10.8 micrograms/L and 264 micrograms/L, respectively.
Elliott 2002
|
|
| |
By applying fragmentation pathways to the aconitines in the ethanolic extract of aconite roots using electrospray ionization/ion trap multistage tandem mass spectrometry, all the known aconitines were detected.
Wang 2002
|
|
| |
Electrospray ionization mass spectrometry combined with multiple tandem mass spectrometry has been applied for simultaneously determining lipo-alkaloids from the aconite tubers. Structures of 12 known lipo-alkaloids including lipoaconitines, lipomesaconitines, were assigned.
Sun 1999
|
|
| |
Analysis of yunaconitine and talatisamine by means of HPLC method, in 10 samples of folk drug Caowu (aconite) shows that the contents and HPLC chromatograms of these alkaloids vary with the samples. [Article in Chinese]
Tong 1991
|
|
| |
Determination of three alkaloids: aconitine, mesaconitine and hypaconitine, contained in 15 samples of Aconite roots by HPLC reveals that most contain the three alkaloids in different contents, and some contain one or two alkaloids. [Article in Chinese]
Tong 1990
|
|
| |
The average recoveries of masaconitine, aconitine and hypaconitine from Aconite roots were 97.3, 96.4, 99.1% and the variation coefficients were 1.81, 1.72, 1.18%, respectively as analyzed by TLC densitometry method. [Article in Chinese]
Wang 1990
|
|
| |
A lectin was isolated from root tubers of winter aconite (Eranthis hyemalis) by affinity chromatography on fetuin-agarose, and it was partially characterized with respect to its biochemical, physicochemical and carbohydrate-binding properties.
Cammue 1985
|
|
| |
[Studies on the ion pair extraction--spectrophotometric method for quantitative determination of aconite alkaloids] [Article in Chinese]
Xiong 1985
|
|
| |
A reliable, reproducible and suitable method for extraction of the crude drug, Aconitum roots, and purification of the extract for its eventual separation and quantitation of the aconitine alkaloids by HPLC technique is described.
Hikino 1983
|
|
| |
[Biological investigation and chemical analysis of big aconite and vine aconites] [Article in Chinese]
Wang 1983
|
|
| |
[High performance liquid chromatographic determination of the main alkaloids in aconite] [Article in Chinese]
Wang 1983a
|
|
| |
[Studies on cardiac principle in Aconite roots. I. Isolation and structural determination of higenamine (author's transl)] [Article in Japanese]
Kosuge 1978
|
|
| |
[Chromatographic and spectrophotometric determination of aconitine in aconite tincture]
[Article in Slovak]
Struh?1969
|
|
| |
[Alkaloids of the chinese drugs, Aconitum spp. ix. alkaloids from Chuan-wu and Fu-tzu, Aconitum carmichaeli debx.] [Article in Chinese]
Chen 1965
|
|
| |
[The alkaloids of chinese drugs, Aconitum spp. 8. alkaloids from Huang-tsao-wu, Aconitum vilmorrianum.] [Article in Chinese]
Chu 1965
|
|
| |
[On the alkaloids of Aconitum ranunculaefolium.] [Article in German]
Mollov 1964
|
|
|
|
| |
[Further studies on cis-aconitic decarboxylase.]
Pal 1964
|
|
| |
[Chromatographic separation of aconitine and pseudo-aconitine.] [Article in French]
Denouel 1963
|
|
| |
[Delphinium dictyocarpum dc. as a source of methyllicaconitine.] [Article in Russian]
Novoseltseva 1963
|
|
| |
Research on the alkaloids of Aconitum ponticum. I. Aconitum ponticum (Rap.) Hand-Mzt.] [Article in Turkish]
Baytop 1962
|
|
| |
[Paper chromatography in the practical study of the hydrolysis of some alkaloid esters. II. Alkaloids of the cocaine, aconitine and eserine groups.] [Article in French]
Vincent 1962
|
|
| |
[Aconite. III. Distribution of alkaloids in plants of various origins. Quantitative study. Toxicity.] [Article in French]
Faugeras 1960
|
|
| |
[Contribution to the determination of the alkaloid content of strychnine and aconite tinctures with aluminum hydroxide (WOELM).] [Article in German]
Kuntze 1959
|
|
| |
[The aconites: study of the distribution of their alkaloids by paper electrophoresis.] [Article in French]
Paris 1959
|
|
| |
[Determination of the total alkaloid content and of the aconitine content of aconite.] [Article in Italian]
Carlassare 1958
|
|
|
Pharmacokinetics (ADME)
|
| |
Examination of Aconite poisoning in 5 patients aged 49 to 78 years old suggested that alkaloid toxicokinetics parameters may reflect the severity of toxic symptoms in aconite poisoning.
Fujita 2007
|
|
|
Contemporary Formulas
|
| |
An electrospray ionization tandem mass spectrometry was used to explore the ester-exchange reactions for aconitine-type diester-diterpenoid alkaloids occurring during the process of decocting aconite root.
Wang 2003
|
|
| |
17 preliminary analysis was carried out on the detoxified recipe and medicines for aconite intoxication in Wu shi er bing fang (Formularies for 52 kinds of disorders). [Article in Chinese]
Tan 2002
|
|
| |
[Formation of an ester of aconitic acid during the stabilization of plant material and during the extraction of organic acids by ethyl alcohol.] [Article in French]
Lascombes 1959
|
|
|
Patents
|
| |
Conduct a search on monkshood or aconite or aconitum in the title, abstract or claims section of the
US patent database
|
|
| |
Conduct a search on aconitine in the title, abstract or claims section of the
US patent database
|
|
|
Cultivation, Conservation & Ecology
|
| |
[Morphological and histological studies on the Chinese medicinal aconite roots, caowu group] [Article in Chinese]
Tong 1986
|
|
| |
[Morphological and histological studies on Chinese medicinal aconite roots, Bangga group and Niubian group] [Article in Chinese]
Tong 1985
|
|
| |
[Morphological and histological studies on the Chinese medicinal aconite roots of miscellaneous group] [Article in Chinese]
Tong 1985a
|
|
| |
[Morphological and histological studies on the Chinese medicinal aconite roots of Xueshangyizhihao group] [Article in Chinese]
Tong 1984
|
|
| |
[A general survey of morphological and histological characters of the Chinese medicinal aconite root] [Article in Chinese]
Tong 1984a
|
|
| |
[Application of statistics on the field of plant internal morphology. IV. On Japanese aconites. (2).]
Saiki 1962
|
|
| |
[Application of statistics in the field of plant internal morphology. V. On Japanese aconites. (3).]
Saiki 1962a
|
|
| |
[Application of statistics on the field of plant internal morphology. III. On Japanese aconites. (1).]
Saiki 1962b
|
|
| |
[Aconite. II. Distribution of alkaloids in plants of various origins. Qualitative study.] [Article in French]
Faugeras 1960
|
|
|
|
| DYNAMIC UPDATES |
| | |
