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| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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Clinical Trials
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The profiles of olive and ash pollen allergens were compared and the degree of cross-reactivity using populations of allergic patients selectively exposed to olive or ash pollen was studied.
Palomares 2006b
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Symptoms of respiratory allergic diseases in the Olea europaea (O.e.) sensitized patients during the O.e. pollination season and after it was observed and documented.
Kirmaz 2005
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Depigmented and glutaraldehyde-polymerized vaccines of Olea europaea pollen are very safe for treating patients with asthma and clinical sensitivity to allergens of this pollen. The clinical efficacy of this new allergen vaccine seems to be dose-dependent.
Guerra 2003
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It is demonstrated that blood pressure and plasma lipids can be modified by the consumption of virgin olive oil in elderly people, but that the extent of such modification depends on the composition and amount of active minor components and triacylglycerol molecular species.
Perona 2003
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Specific immunotherapy (SIT) with olive extract in a group of rhinitic and/or asthmatic patients monosensitized to olive was investigated and it was found that SIT with olive extract proved to be safe and efficacious for asthma and rhinitis.
Gonz?z 2002
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Significant correlations among daily counts of Olea pollen and rhinitis symptoms were obtained. Most monosensitized patients needed a high Olea pollen concentration in the atmosphere (around 400 grains/m3) to suffer at least from mild allergic rhinitis symptoms.
Florido 1999
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Thirty eight patients from two geographical areas of Spain, with great differences in Olea europaea pollen counts were studied to investigate their in vivo and in vitro immune response to this pollen as a consequence of their different environmental allergen exposure.
Casanovas 1997
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A clinical assay of Olea europaea aqueous extract on two groups of patients suffering with essential hypertension showed a statistically significant decrease of blood pressure in all patients and didn't find any side effect in the two groups. [Article in French]
Cherif 1996
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A clinical assay of Olea europaea aqueous extract was carried out on two groups of patients suffering with essential hypertension, and found a statistically significant decrease of blood pressure for all patients without side effects.
Cherif 1996 [Article in French]
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The cutaenous and serological responses to other oleaceae pollens allergens (Ligustrum vulgare and Fraxinus excelsior) in 23 patients with skin positivity to Olea europaea pollen extract was evaluated.
Liccardi 1995
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The clinical efficacy and safety of immunotherapy with an extract of the pollen of the tree Olea europaea administered sublingually in 15 patients allergic to this pollen with rhinitis and/or rhinoconjunctivitis was evaluated.
Casanovas 1994
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The relationship between HLA class II haplotypes and alleles, and the IgE antibody response to a highly purified allergen, Ole e I, in allergic patients was studied.
C?aba 1993
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Olive pollen-specific IgG4 levels were determined in 100 patients, 39 of whom had been subjected to no immunotherapy (IT) for Olea (31 allergic and 8 nonallergic individuals) and 61 of whom had been administered IT as extracts, including Olea pollen.
Guerra 1992
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The changes in specific skin reactivity, specific IgE and specific IgG after immunotherapy were investigated in olive pollinosis with thirty patients.
Macchia 1991
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Observational Studies/Case Reports
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The prevalence of specific IgE (includes a cross-reactive carbohydrate determinants (CCDs), pollens (Lolium perenne & Olea europaea), Hymenoptera venoms & a mite) to CCDs in adults, and its relation to alcohol consumption was investigated in a Population-based survey of 457 adults.
Gonzalez-Quintela 2007
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A case of asthma caused by black seed used as canary food in a 42-year-old woman patient previously allergic to pollen (olea europaea, grass, and mugwort) and sunflower seeds was reported.
Rodr?ez 2003
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A study on cross-reactivity between 4 species of Oleaceae: Olea europaea, Fraxinus excelsior, Ligustrum vulgare & Syringa vulgaris with 51 patients & 13 atopic controls revealed that only O.europaea extract be used in diagnosis & immunotherapy in Oleaceae pollen allergy.
Pajar?997
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Among 187 patients living in Madrid and who came to our centre with a history of rhinitis and/or seasonal asthma, a prevalence of positive skin-prick tests to Platanus of 56%, only surpassed by gramineous pollen 92% and Olea europaea 63% was found.
Subiza 1994
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Traditional and Folk Use
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Six species including tea and chamomile, Jasonia glutinosa, J. tuberosa, have been used for digestive disorders. Rhamnus alaternus, Olea europaea... have been used in high blood pressure in Navarra.
Akerreta 2007
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Documentation of the medicinal plants used to treat endoparasites and stomach problems in dogs, cats and pigs in British Columbia, Canada indicates that 14 plants including Olea europaea were used as anthelmintics.
Lans 2007
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In the Errachidia province in south-eastern Morocco region, the most frequently used plants to treat diabetes and arterial hypertension include Ajuga iva, Allium cepa, Artemisia herba-alba, Carum carvi, Nigella sativa, Olea europea.
Tahraoui 2007
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The use of various taxa in managing malaria menace was compared between five districts within Central Province of Kenya. The commonest species in this pharmacopoeia are: Caesalpinia volkensii Harms, Strychnos henningsii Gilg, Ajuga remota Benth., Warbugia ugandensis Sprague and Olea europaea L.
Njoroge 2006
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Adverse Effects & Toxicity
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Lower respiratory tract obstruction can occur after nasal provocation tests with methacholine as a nonspecific stimulant, therefore, tests performed with nasal Olea europaea extract as a specific allergen in 36 participants was regarded as safer.
Kirmaz 2007
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Patients with anaphylactic reaction after eating fruit are also sensitized to Ole e 7, a LTP present in Olea pollen, and suffer pollinic symptoms and polcalcin (Ole e 3) possibly also associated with Olea pollen respiratory and food allergy.
Florido Lopez 2002
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[Cross-reactivity between olive and other species. Role of Ole e 1-related proteins.]
Lombardero 2002
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The prevalence of Ole e 2 for olive allergenic patients has been evaluated by different in vivo and in vitro methods, and the results compared with those obtained for another pollen profilins.
Mart?z 2002
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It is indicated that Ole e 1 and Ole e 2 are major allergens in patients with Olea europaea pollinosis in population of the Mediterranean area.
Quiralte 2002
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Presence of IgE antibodies(IgE AB)to allergens rBet v 1& rBet v 2 was investigated in 10 patients with known sensitization & allergic symptoms to ryegrass and/or olive pollen. All patients showed specific IgE to both fruit & incidence of IgE AB to rBet v 2 was 90%.
Daschner 1998
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Investigation of prevalence of atopic disease, skin test reactivity, total & specific IgE to common allergens, & other variables in a sample of students from M?ga, southern Spain indicates that dermatophagoides pteronyssinus & pollen of Olea europaea were found to be the most common allergens.
Garc?Gonz?z 1998
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92 patients with allergic rhinitis were studied in Japan during pollen season to evaluate cross-reactivity to different antigens including pollen from Olea europaea & orchard grass. There was a reaction in some patients to grass pollinosis that might be induced by Olea pollen.
Miyahara 1997
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Investigation on the incidence of skin-tested sensitivity to olive pollen allergens among subjects with suspected atopic respiratory allergy in various populations of Israelis was carried out.
Geller-Bernstein 1996
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The incidence of positive skin test responses among atopic subjects with suspected respiratory allergy was investigated with commercial and autochthonous pollen extracts of various cultivars of Olea europaea.
Waisel 1996
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Olea europaea, the olive tree with cultivation widespread in the whole Mediterranean basin, is responsible for frequently severe pollinosis, particularly in some regions of the southern Italy.
D'Amato 1992
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It has been found that there is a high degree of cross-reactivity among allergens from native Michigan trees and from olive trees and the cross-reactivity is the most likely reason for skin test reactivity to olive pollen extract in Michigan.
Kernerman 1992
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Animal Studies
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Oleuropein may be of advantage in inhibiting hyperglycemia and oxidative stress induced by diabetes in diabetic Rabbits and the administration of oleuropein may be helpful in the prevention of diabetic complications associated with oxidative stress.
Al-Azzawie 2006
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The mouse model of olive pollen sensitization mimics immunologic features of human pollinosis and could be a useful tool for designing novel forms of immunotherapy for olive pollen allergy based on allergen cocktails.
Barral 2006
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BALB/c mice immunized against Ole e 9 developed a predominantly Th2-like immune response with allergen-specific immunoglobulin induction and airway inflammation accompanied by the infiltration of eosinophils, lymphocytes, and neutrophils in the lung.
Palomares 2006
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Olive leaf extract significanlty increased SOD expression in stimulated rat epithelial lung cells when compared to controls.
Mader 2004
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Three isolates of Olea europaea at a dose of 60 mg/kg b.w. for 6 weeks treatment, prevented the development of severe hypertension and atherosclerosis and improved the insulin resistance of Dahl salt-sensitive, insulin-resistant rat.
Somova 2003
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The effect of an aqueous extract of olive (Olea europaea) leaf on the thyroid activity in rats suggest a stimulatory action on the thyroid, unrelated to the pituitary.
Al-Qarawi 2002
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In this study, polyphenolic extract of Olea europaea leaves showed a significant anticlastogenic activity both before and after X-ray irradiation treatments in the bone marrow of mice.
Benavente-Garcia 2002
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A specially prepared olive leaf extract has been tested for its blood pressure lowering activity in rats rendered hypertensive by daily oral doses of L-NAME (NG-nitro-L-arginine methyl ester, 50 mg/kg) for at least 4 weeks.
Khayyal 2002
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These findings confirm previous reports on the hypotensive effects of olive leaf extract. The extract was shown to give consistent results with little individual variability for induced hypertension in rats.
Pacheco 2002
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Repeated administration of aqueous leaf extract of Olea europaea in female and male rats for 60 days induced an increase of weight growth, an hypotension, an hypoglycaemia and an hypouricaemia. [Article in French]
Fehri 1994
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The apparent digestibility of the dietary fibre and other components of the olive (Olea europaea arolensis) was studied using young Wistar rats revealing significant differences in the digestibility of dry matter, fibre, cellulose and lignin, but not in proteins and fat.
Heredia 1993
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This study found that maximum hypoglycemic activity from olive leaf was obtained from the winter month samples. One of the compounds responsible for this activity was oleuropeoside and demonstrated antidiabetic activity in animals with alloxan-induced diabetes.
Gonzalez 1992
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Antihypertensive effects in SHR rats were observed after the administration of Allium sativum Linn. (bulb), Olea europaea Linn. (leaf) and Hedychium coronarium Koen. (leaf-blade).
Ribeiro 1986
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Pharmacodynamics
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The protective effects of olive (Olea europaea L.) leaves were investigated by incubating human promyelocytic leukemia HL-60 cells with olive leaf extracts from seven principal Tunisian olive varieties, namely, Chemchali, Chemlali, Ch?ui, Gerboui, Sayali, Zalmati and Zarrazi.
Abaza 2007
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The adsorption isotherms of oleuropein and rutin were evaluated at different temperatures, pH values, and solid/liquid ratios. The maximum adsorption capacities were determined as 108 mg of oleuropein/g of silk fibroin and 21 mg of rutin/g of silk fibroin.
Bay? 2007
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The antimycobacterial activity of nine plants including Musa acuminata and Olea europaea, used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases were evaluated including against drug-resistant M. tuberculosis isolates.
Camacho-Corona 2007
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An experimental model of allergic lung inflammation based on a relevant human allergen, olive pollen was developed and the immunological, cellular and functional airway features of the allergic response in this model was established.
Conejero 2007
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Investigation of the immunochemical characteristics of 6 varieties of Olea europaea collected during 5 consecutive years shows that the different varieties of O. europaea pollen demonstrated great differences in allergenic potency and Ole e 1 content.
Fern?ez-Caldas 2007
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The effects of maslinic acid, a triterpenoid compound present in fruit and leaves of Olea europaea on growth, protein-turnover rates and nucleic acid concentration in trout white muscle was investigated.
Fern?ez-Navarro 2007
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A TLC analysis combined with two bioassays were used to detect the antioxidant and anti-rhizopus activities of 18 Lamiaceae medicinal and aromatic plants including Lycopus europaeus, Melissa officinalis, Origanum vulgare subsp. virens and Lavandula latifolia.
L? 2007
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The 135Delta10 mutant with reduced allergenicity, intact T cell reactivity and capacity to induce blocking antibodies could provide a suitable candidate vaccine for efficient and safer therapy of olive pollen allergy.
Marazuela 2007
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It has been suggested that both oleuropein and oleanolic acid, a TGR5 agonist isolated from Olea europaea are involved in the anti-diabetic effect of olive leaves.
Sato 2007
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Olive leaf polyphenols derived from Olea europaea L. leaves inhibited in vitro platelet activation in healthy, non-smoking males.
Singh 2007
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The highest radical-scavenging activity was found in 12 of the 55 herbs including olive leaf, black cohosh, rhubarb, licorice and Virginia skullcap.
Wojcikowski 2007
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Immunologic characterization was performed using immunoblotting and enzyme-linked immunosorbent assay, and histamine release assays with serum samples from allergic patients with well-known reactivity to Fra e 1 or Ole e 1 and with polyclonal antiserum and monoclonal antibodies against Ole e 1.
Barderas 2006
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The antifungal activity of the aldehydes from olive fruit substantiates the use of olive and olive oil in skin diseases and suggests that these natural compounds could be useful agents in the topical treatment of fungal cutaneous infections.
Battinelli 2006
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By using a rabbit antiserum raised to p1 protein, the proteins have been immunolocalized in olive seed tissues, showing that they accumulate in conspicuous protein bodies present in both the endosperm and the cotyledon.
de Dios Alch?006
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An immunoassay was developed to measure Ole e 9 concentration and the variability of this allergen in olive pollen extracts was studied.
Duffort 2006
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The immune reactivity of natural & recombinant major allergens of birch pollen (Bet v 1), grass pollen (Phl p 1 & 5), olive pollen (Ole e 1), & house dust mite (Der p 1 & 2, and Der f 1 & 2) was analysed. For olive, rOle e 1 had a lower IgE binding in RAST but a higher activity in histamine release.
Fernandez-Rivas 2006
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The suitability of using the N- and C-terminal domains of the 1,3-beta-glucanase Ole e 9, a major allergen from olive pollen, for in vitro diagnosis was analyzed.
Palomares 2006a
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Among the 6 compounds isolated and characterized the hydroxytyrosol showed a higher activity than the natural antioxidant rosmarinic acid in scavenging the DPPH model radical. Ligustroside, tyrosol and 7-deoxyloganic acid showed little activity.
P?z-Bonilla 2006
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The in vivo & in vitro characteristics of 3 different types of extracts of Phleumpratense, Olea europaea, Parietaria judaica & Dermatophagoides pteronyssinus were evaluated which showed that the polymerised depigmented extracts are less allergenic than corresponding native & depigmented extracts.
Casanovas 2005
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It is proposed that Oleuropein (Ole), the major phenolic constituent of the olive leaf induces lipid structures similar to the gel-fluid intermediate phase described for PG membranes, in a similar way than low ionic strength does.
Caturla 2005
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Extracts of 21 plants including Origanum vulgare, Melissa officinalis, used in Bulgarian phytotherapy for the treatment of respiratory, gastrointestinal and other inflammatory disorders were screened in vitro for antioxidant activity and phenolic compounds content.
Ivanova 2005
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It is proposed that Olea europaea could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment.
Micol 2005
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Neisseria gonorrhoeae clinical isolates and WHO strains were sensitive to extracts of Ocimum sanctum, Drynaria quercifolia, and Annona squamosa.
Shokeen 2005
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This study reported significant, dose-response vasodepressor effect and sinus bradicardia from four triterpenoid derivatives isolated from the leaves of African wild olive (Olea europaea).
Somova 2004
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The suitability of poly(D,L-lactide-co-glycolide) microparticles as a vaccine delivery system for Ole e 1 in therapy against olive allergy has been evaluated.
Batanero 2003
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Beta-sitosteryl-D-glucoside and oleuropein isolated from the olive tree (Olea europaea) and their hydrolysed derivatives were tested by a feeding stimulative activity bioassay using the olive weevil (Dyscerus perforatus).
Kadowaki 2003
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Antioxidant activity of maslinic acid, from Olea europaea was investigated on the susceptibility of plasma or hepatocyte membranes to lipid peroxidation, induced respectively by the hydroxyl radical (OH*) generated by Fe2+/H2O2 ex vivo and by the system Fe3+/ascorbate in vitro.
Montilla 2003
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A murine model of IgE sensitization to Ole e 1, the major allergen of olive pollen, which mimics the immunological features of olive pollinosis in humans was developed and the in vivo antigenicity of the recombinant form of the allergen was investigated.
Batanero 2002
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[Ole e 4 and Ole e 5, important allergens of Olea europaea.]
Carn?2002
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The antigenic and allergenic composition of six different Olea europaea varieties collected in southern Spain was investigated.
Carn?S?hez 2002
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[Antigenic and allergenic differences between 16 different cultivars of Olea europaea.]
Conde Hern?ez 2002
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The IgE from sera of olive-allergic patients showed a significant diversity of binding capacity to the members of the Ole e 1-like family due to the microheterogeneity of their polypeptide sequences, in spite of their highly conserved primary structures.
Gonz?z 2002
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Thirty-four (17%) and 16 (8.2%) out of 195 sera from patients allergic to olive pollen contained specific IgE against Ole e 3 and Ole e 8, respectively. The IgE-binding of 12 allergic sera diminished up to 22% for Ole e 3 and to 82% for Ole e 8, when depleted Ca2+.
Ledesma 2002
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The in-vitro antioxidant activity of natural(essential oils of cilantro, fennel, salvia negra, oregano& vitamin E) or synthetic substances ( tert-butyl hydroxy anisole, Trolox) have been evaluated by monitoring volatile carbonyl compounds released in model lipid systems subjected to peroxidation.
Stashenko 2002
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Essential oil of Ocimum sanctum and eugenol, tested in vitro, showed potent anthelmintic activity.
Asha 2001
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The 'in vitro' activity of 8 aliphatic long-chain aldehydes from olive flavor including hexanal, nonanal, (E)-2-hexenal, against a number of standard and freshly isolated bacterial strains that may be causal agents of human intestinal and respiratory tract infections was reported.
Bisignano 2001
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In addition to potential employment of its active principles as food additives or in integrated pest-management programs, Olea europaea can be also considered as a source of promising antimicrobial agents for treatment of intestinal or respiratory tract infections in humans.
Bisignano 1999
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A series of alpha, beta-unsaturated aldehydes, characterized from the olive oil flavor was found to inhibit the oxidation of L-3, 4-dihydroxyphenylalanine catalyzed by mushroom tyrosinase, & the inhibition kinetics analyzed by a Lineweaver-Burk plot found that they are noncompetitive inhibitors.
Kubo 1999
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The 36-kDa protein constitutes a major allergen for olive-sensitized patients, but it is not equally represented in Olea europaea pollens of different origins.
Mart?z 1999
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A new olive pollen allergen, Ole e 7 of clinical significance has been purified and characterized, contributing to the study of the complete allergogram of the olive tree pollen.
Tejera 1999
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Using the purified monoclonal antibodies produced against sunflower profilin, the common epitope determinants in pollens of different plants like Olea europaea, Cynodon dactylon, have been analyzed.
Arilla 1997
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It was found that IgG4 antibody specific for aeroallergens (i.e., from pollens of several species of Gramineae, Olea europaea, and Parietaria judaica and from house dust) usually exhibits high affinity, except for Dermatophagoides pteronyssinus.
Boluda 1996
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From extracts of olive (Olea europaea) leaves several flavanoids were isolated and strongly inhibited the classical pathway of the complement system.
Pieroni 1996
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Oleuropeoside, a compound in olive leaf decoction, caused relaxation of isolated rat aorta preparations both in the presence and in the absence of endothelium. It seemed likely that at least one other unknown compound was also active.
Zarzuelo 1991
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Study on the importance of the smooth vascular muscle endothelium in the vasodilator action of olive leaf shows that oleuropeoside is a component responsible for vasodilator activity.
Zarzuelo 1991
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[A review of the investigations on hypotensive substances from the leaves of the olive tree, Olea europaea L.] [Article in Dutch]
Julius-Bijlsma 1961
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Analytical Chemistry
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A set of minor constituents of Olea europaea L. leaves have been identified and characterized by electrospray ionization tandem mass spectrometry and high-resolution measurements.
Di Donna 2007
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Two neutral triterpenes and a triterpene acid were identified and quantified directly, in the absence of any purification steps, in a precipitate obtained during the industrial extraction of the leaves of Olea europaea L. using 13C-NMR spectroscopy.
Duquesnoy 2007
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The determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD was reported and their in vitro activity evaluated against several microorganisms that may be causal agents of human intestinal and respiratory tract infections.
Pereira 2007
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From the cell suspension cultures of Olea europaea, 6 ursane type triterpene acids including ursolic acid, pomolic acid, and 2 oleanane type acids, oleanolic acid and maslinic acid were isolated.
Saimaru 2007
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Some new rapeseed varieties and olive genotypes grown in northwest Turkey were investigated and the tocopherol fractions and contents of both crops were compared using the high-performance liquid chromatographic method.
Seker 2007
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[NMR assignment of the C-terminal domain of Ole e 9, a major allergen from the olive tree pollen.]
Castrillo 2006
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The peak areas from a high-performance liquid chromatography-diode array analysis of biophenols extracted from olive leaves were used as chemotaxonomic markers to construct chemometric models in order to discriminate and classify 13 varieties of Olea europaea olive trees.
Jap?ujan 2006
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2 secoiridoid glycosides were isolated together with 3 known glycosides, oleuropein, oleoside dimethyl ester & secologanoside, from the methanol extract of boron deficient Olea europaea leaves. The structures of isolated compounds were established by means of NMR & MS spectral analyses.
Karioti 2006
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Lipoxygenase from olive fruit was purified to homogeneity for the first time after differential centrifugations and by hydrophobic chromatography.
Lorenzi 2006
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From twenty three samples of 18 Portuguese olive leaf cultivars analysed by a reversed-phase HPLC/DAD procedure, eight flavonoidic compounds were identified and quantified.
Meirenhos 2005
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In this report, the radical scavenging potential of phenolic compounds occurring in Olea europaea and of recently identified hydroxytyrosol metabolites was evaluated by means of quantum chemical calculations.
Nenadis 2005
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A new tyrosol derivative, the oleic ester of tyrosol, was isolated from fruits of Olea europaea, Cassanese cultivar. Salidroside, the known glucosyl derivative of thyrosol, was isolated from the Carolea cultivar.
Bianco 2004
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In this study, identification and quantification of phenolic compounds of the Olea europaea L. cv. Chemlali olive were carried out to examine their profile during maturation.
Bouaziz 2004
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In this study, 1,5-Anhydroxylitol, a compound never found previously in the vegetal kingdom was obtained from Olea europaea leaves in approximately 0.5-1% yield.
Campeol 2004
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The chemical composition of the volatile fractions from leaves of three Olea europaea L. cultivars (Leccino, Frantoio, and Cipressino) harvested at two different times of the year were examined by GC and GC-MS.
Campeol 2003
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A simple method is described for the determination of the ionic content of vegetable samples like extracts of leaves of cucumber, and leaves and roots of Olea europaea by ion chromatography with suppressed conductivity detection.
Cataldi 2003
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The volatiles produced by leaves and fruits of Olea europaea cv. Olivastra Seggianese have been analyzed in two different phenological stages by means of hydrodistillation and SPME. The major constituents were often aldehydes, particularly (E)-2-hexenal (9.8-48.0%).
Flamini 2003
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Two compounds (-)-olivil and (+ )-1-acetoxypinoresinol isolated from Olea europaea showed potent feeding stimulant activity on olive weevil.
Kadowaki 2003
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This investigation characterized phenolic metabolism of the olive cultivar, Hardy's Mammoth, pulp, seed, stone, and new and old season leaves.
Ryan 2003
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Solid-phase microextraction was employed to characterize the volatile profile of virgin olive oils produced in two geographical areas of northern Italy: the region of the Gulf of Trieste and the area near Lake Garda.
Vichi 2003
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Researchers developed a protocol for isolating proteins suitable for two-dimensional electrophoresis (2-DE) from olive leaf.
Wang 2003
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Ole e 1 enzyme-linked immunoadsorbent assay was found to be sensitive, reproducible, specific, and reliable, and therefore, can be helpful for standardization of olive pollen extracts intended for clinical use.
Arilla 2002
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This study used non-homogeneous hyperthermophilic beta-glycosidase immobilised on chitosan, 3,4-dihydroxy-phenylethanol to biotransform oleuropein found in leaf extracts from Olea europaea to hydroxytyrosol.
Briante 2002
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The phenolic composition of olive fruits grown in different areas of Spain was studied by high performance liquid chromatography-mass spectrometry. Different levels of tyrosol, catechin, p-coumaric acid, rutin, luteolin, and oleuropein were observed in the different varieties analyzed.
Bot?2001
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The chemical compositions of the volatile fractions from three Olea europaea L. cultivars were distinguished by GC and GC-MS.
Campeol 2001
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A novel major allergen, Ole e 9, has been isolated from olive pollen by gel permeation, hydrophobic affinity, and reverse-phase high performance liquid chromatography.
Huecas 2001
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Olea europaea leaves of 14 different cultivars have been studied by a new isocratic HPLC method and the qualitative and quantitative determinations of principal compound, oleuropein, was established for each cultivar.
Savournin 2001
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Qualitative and quantitative determinations of 0leuropeins were established for 14 different cultivars of Olea europaea using an isocratic HPLC method.
Savournin 2001
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An anion-exchange chromatographic method that uses isocratic elution and pulsed amperometric detection was described to provide a rapid and convenient means to obtain a complete profile of the sugar components of leaves and roots from olive plants.
Cataldi 2000
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The structure of the isolated recombinant Ole e 1 was determined by chemical and spectroscopic techniques, and its immunological properties analysed by blotting and ELISA inhibition with Ole e 1-specific monoclonal antibodies and IgE from sera of allergic patients.
Huecas 1999
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This comparison shows significant quantitative differences in some polyphenols, such as verbascoside, anthocyanic compounds, and oleuropein derivatives in among different cultivars of Tuscan Olea europaea.
Romani 1999
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The results demonstrate the potential of electrospray ionisation mass spectrometry for the specific detection and identification of oleuropein and isomers of verbascoside from Olea europaea.
Ryan 1999
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Hesperidin, rutin, luteolin-7-O-glucoside, apigenin, apigenin-7-O-glucoside, quercetin, kaempferol were isolated and identified from the dried leaves of some blooming cultivars of Olea europaea using by UV, 1H-NMR, 13C-NMR, HPLC.
de Laurentis 1998
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The Ole e 6 allergen from olive tree pollen has been isolated by combining gel permeation and reverse-phase chromatographies.
Batanero 1997
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[Application of NMR microscopy to the histochemistry study of olives (Olea europaea L.).]
Gussoni 1993
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A two-site solid-phase radioimmunoassay developed for the quantitation of olive allergen Ole e I in mass units can be a good alternative to RAST inhibition for the standardization of Olea europaea extracts.
Lombardero 1992
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Reversed phase high-performance liquid chromatography was used for qualitative and quantitative analysis of secoiridoid oleuropein and some flavonoids in leaf and bud extracts of Olea europaea
Ficarra 1991
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[Oleuropeic acid: a new compound from Olea europaea.]
Shasha 1959
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Pharmacokinetics (ADME)
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Olive polyphenols were absorbed and metabolized within the body, occurring in plasma mainly in the conjugated form with glucuronic acid and reaching C(max) in 1-2h in healthy volunteers who had consumed 20 olives. Excretion rates were maximum at 0-4h.
Kountouri 2007
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Genetics & Molecular Biology
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The pattern of genetic variability and genetic relationships of wild olive (Olea europaea subsp. europaea var. sylvestris) populations in the north-western Mediterranean was examined.
Belaj 2007
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Representatives of the six olive subspecies were investigated for polyploidization using flow cytometry to estimate genome content, and six highly variable nuclear microsatellites to assess the presence of multiple alleles at co-dominant loci.
Besnard 2007
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To analyze sugar transport processes in Olea europaea, a cDNA encoding a monosaccharide transporter, designated OeMST2 (Olea europaea monosaccharide transporter 2) was cloned.
Conde 2007
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The effectiveness of microsatellite analysis in verifying identity of Collina di Brindisi protected designation of origin(PDO)olive oil was verified & results showed that examination of limited number of DNA microsatellites enables identification of Ogliarola salentina cultivar in this PDO oil.
Pasqualone 2007
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Genotyping with microsatellite-based markers (MBM) of the olive for potential application of olive as legal case evidence, with regard to the degree of variability within the Croatian olive genomic pool and to the effectiveness of the chosen set of MBM in revealing olive divergence was assessed.
Stambuk 2007
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The impact of the genetic factor on the contents of oleuropein in olive leaves was evaluated but the influence exerted by the color/age of leaves (green, green-yellowish, and yellow) and the collecting period (spring or autumn) was also evaluated.
Ranalli 2006
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The set of predominantly SNP-based markers was used to genotype 65 olive samples obtained from Europe and Australia, and was able clearly to discriminate 77% of the cultivars.
Reale 2006
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Genetic structure and evolutionary patterns of the wild olive tree (Olea europaea L.) were investigated with AFLP fingerprinting data at three geographic levels including phylogenetic relationships of the six currently recognized subspecies in Eurasia and Africa.
Rubio de Casas 2006
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To study the molecular bases of water transport in olive, cDNAs from Olea europaea cv "Leccino" related to the aquaporin gene family was characterized.
Secchi 2006
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In olive plants, salinity causes reactive oxygen species-mediated oxidative stress, and plants respond to this situation by inducing different antioxidative enzymes, especially the NADPH-producing dehydrogenases in order to recycle NADPH necessary for the protection against oxidative damages.
Valderrama 2006
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The complete nucleotide sequence of a virus isolated from Olea europaea L. (GP isolate), previously identified as an isolate of Tobacco necrosis virus D (TNV-D) based on its coat protein sequence, was determined.
Cardoso 2005
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The effects of some dietary non-flavonoid phenols from Olea europaea L., both in purified form or in complex mixtures obtained by biotransformation of olive leaf extracts, on the LDL oxidation induced by Cu2+ ions have been studied.
Briante 2004
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In this study unique DNA fingerprint profiles for each olive clone were produced using optimized AP-PCR amplification protocol.
Kockar 2003
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A linkage map of the olive (Olea europaea L.) genome was constructed using random amplified polymorphic DNA and amplified fragment length polymorphisms as dominant markers and a few restriction fragment length polymorphisms and simple-sequence repeats as codominant markers.
la Rosa 2003
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The transferability of microsatellite markers developed for olive cultivars ( Olea europaea L.) has been tested and confirmed in the Olea complex. Thirty two genotypes, belonging to different taxa of the genus Olea were analyzed with four olive SSRs.
Rallo 2003
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In this study, 52 microsatellites or simple sequence repeats (SSRs) from nearly 60 positive clones obtained from two 'Frantoio' olive genomic libraries enriched in (AC/GT) and (AG/CT) repeats were isolated and sequenced.
Cipriani 2002
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It is suggested that the inter- and intraspecific changes in the nuclear and genomic traits observed can contribute to the understanding of the phylogenetic relationships between Olea species and in defining parameters to be exploited in varietal identification within cultivated olives.
Bitonti 1999
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Modern Methods of Preparation
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Total polyphenol content of palm oil, olive oil, and sunflower oil supplemented with an extract rich in polyphenols obtained from olive tree leaves were estimated by the Folin-Ciocalteau assay, oleuropein was determined by HPLC analysis, while other individual polyphenols by GC/MS analysis.
Chiou 2007
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Macroporous resin D-101 fits in purification of water-soluble oleuropein and the process was found to be simple and convenient and can be used for industrial production. [Article in Chinese]
Dang 2007
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Olives (Olea europaea cv. Chondrolia) stored under a CO2 atmosphere immediately after harvesting for a period of 12 days were analyzed by HPLC to identify components that may reflect changes in the biochemical behavior of the tissue.
Dourtoglou 2006
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Virgin oil extracted from heated fruit of olives (Olea europaea L.) of the Manzanilla, Picual, and Verdial varieties showed higher concentrations of chlorophylls and carotenes and lower total phenol content.
Garc?2005
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A large amount of highly purified hydroxytyrosol was obtained in a short time by biotransformation of Olea europaea leaf extract with partially purified hyperthermophilic beta-glycosidase immobilized on chitosan support.
Briante 2004
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Ole e 1, was entrapped in poly (DL-lactide glycolide) micro-particles & it was suggested that microparticles of small particle sizes, rapid antigen release & a high allergen/polymer ratio may be a suitable delivery system for antigen in hyposensitization therapy against allergy.
Batanero 2002
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It has been found that heating of olive fruits promotes a reduction of oil bitterness in direct relationship to the time and temperature used and for each olive variety, a good correlation between oil bitterness and content of hydroxytyrosol secoiridoid derivatives was found.
Garc?2001
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Poly (D,L-lactide-co-glycolide) microspheres encapsulating Olea europaea pollen extracts were prepared by using the double emulsion (w/o/w) based on a solvent evaporation/extraction method.
Igartua 2001
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Patents
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Conduct a search on "Olea europaea" or "olive leaf" in the title, abstract or claims section of the
US patent database
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Cultivation, Conservation & Ecology
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The kinetics and molecular properties of polyphenol oxidase (PPO) in fruits and leaves of olive (Olea europaea L.) cv. 'Picual' trees and the relationship between PPO and oleuropein concentration during fruit ripening was studied.
Ortega-Garc?2008
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Xylem ultrastructural modification and the possible participation of phenolic compounds in the natural defense or resistance mechanisms of olive plants infected with Verticillium dahliae Kleb. were studied.
B?ez 2007
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The origin of invasive olives was determined and the importance of historical effects on the genetic diversity of populations was investigated.
Besnard 2007
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The low-affinity, high-capacity, diffusional component of glucose uptake in Olea europaea cell cultures occurs through a channel-like structure whose transport capacity may be regulated by intracellular protonation and phosphorylation/ dephosphorylation.
Conde 2007
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Mannitol transport and compartmentation by OeMaT are important to allocate the source of carbon and energy, as well as for salt tolerance and olive ripening.
Conde 2007
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It is shown that osmotin is positively involved in the acclimation-related programmed cell death, in blocking the cold-induced calcium signalling, and in affecting cytoskeleton in response to cold stimuli of olive tree.
D'Angeli 2007
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The dynamics of airborne Olea europaea pollen in contrast to the allergenic activity of Ole e 1 in the atmosphere was analysed.
De Linares 2007
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It is shown that olive tree bark possesses an efficient photosynthetic mechanism that may significantly contribute not only to the reduction in concentrations of CO(2) in the inner bark, but also to whole-tree carbon balance.
Filippou 2007
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The changes in allomerized chlorophyll during growth & development of olive fruit as well as during the main operations of its processing as green table olive (alkaline treatment and lactic fermentation) were investigated to study their influence in the color alteration known as green staining.
Gallardo-Guerrero 2007
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Study on the effects of sewage sludge application on the soil and olive trees suggests regulations about the utilization of sewage sludge on agricultural land should consider the limit values for salt, and not only metals, in order to minimize the risk of negative effects to plant health.
Gasc?07
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Characterization of four cultivars of the olive trees, Ch?ui, Chemlali, Gerboui, and Cha?, cultivated in three different geographical locations, from pomological and technological points of view was carried out. [Article in French]
Hannachi 2007
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The growth, leaf gas exchange characteristics, water relations, chlorophyll fluorescence, and Na(+) and Cl(-) concentration of two cultivars ('Koroneiki' and 'Picual') of olive trees in response to high salinity (NaCl 100mM) and elevated CO(2) concentration (700muLL(-1)) was compared.
Melgar 2007
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Study of some cement dust effects on olive leaf physiology indicates that dust seems to cause substantial changes to leaf physiology, possibly leading to reduced olive productivity.
Nanos 2007
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Soil application of diuron & simazine herbicides reduced the efficiency of Photosystem II photochemistry of olive trees due to chronic photoinhibition, and this effect was counterbalanced by the addition of organic waste to the soil.
Redondo-G? 2007
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It is found that olive plants exploit the high diversity of the carbohydrate spectrum in specific response to different stresses.
Rejskov?007
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The crude extract of the polyphenol oxidase enzyme from the Manzanilla cultivar (Olea europaea pomiformis) was obtained, and its properties were characterized.
Segovia-Bravo 2007
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The irrigation effects on quality, phenolic composition, and selected volatiles of virgin olive oils cv. Leccino were investigated. Field-grown olive trees were used over two growing seasons to determine the effect of deficit irrigation regimes on virgin olive oil quality.
Servili 2007
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The developing olive fruit was found to accumulate significant amounts of parkeol as an ester conjugate and whatever the stage of development, triterpenoids represent the major triterpenic compounds of the olive fruit.
Stiti 2007
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Saissetia oleae (Olivier) (Hemiptera: Coccidae) populations were studied and compared in citrus and olive (Olea europaea L.) groves to determine the number of generations, crawler emergence periods and changes in population density during the year.
Tena 2007
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Examination and analysis of olive (Olea europaea L.) trees growing in close proximity to a copper dominated spoil tip dating from at least 2000 years BP, on the island of Cyprus, revealed both bioaccumulation and partitioning of copper, lead and zinc in various parts of the tree.
Wilson 2007
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The phenolic composition of wastewaters prepared from different cultivars of Olea europaea for technological utilization has been described.
Bianco 2006
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In olive leaves, the SOD enzymatic system was characterized and was found to be comprised of three isozymes, an Mn-SOD, an Fe-SOD and a CuZn-SOD.
Corpas 2006
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The osmotic adjustment capacity of leaves and roots of young olive (Olea europaea L.) trees during a period of water deficit and subsequent rewatering was evaluated.
Dichio 2006
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The results of excision and perfusion calibration experiments made with mature olive (Olea europaea L. 'Manzanilla de Sevilla'), plum (Prunus domestica L. 'Songal') and orange (Citrus sinensis (L.) Osbeck. 'Cadenero') trees were compared.
Fern?ez 2006
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Soil erosion, runoff and nutrient-loss patterns over a two-year period (1999-2000) were monitored in erosion plots on a mountainside with olive (Olea europaea cv. Picual) trees under 3 different types of soil management including non-tillage with barley (Hordeum vulgare) strips of 4m width.
Francia Mart?z 2006
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The effect of both the degree of ripening of the olive fruit and irrigation management-rain-fed, two different regulated deficit irrigations on the phenolic and volatile composition of Cornicabra virgin olive oils obtained during two crop seasons was investigated.
G?-Rico 2006
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Two EF-hand-type Ca2+-binding allergens from olive pollen, Ole e 3 and Ole e 8, were produced in transgenic Arabidopsis thaliana plants.
Ledesma 2006
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The specific quantification of aeroallergens Ole e 1 and Par j 1-Par j 2 Olea and Urticaceae pollen counts was compared.
Moreno-Grau 2006
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The antigenic profile of Olea europaea pollen from different Mediterranean cultivars was obtained by MALDI mass spectrometry.
Napoli 2006
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[Aftermath of the long-term application of sludge and water from a sewage treatment plant to an olive tree (Olea europaea L.) plantation.]
Menti 2005
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It is indicated that careful planning in orchard design is required for efficient pollination between olive cultivars.
Mookerjee 2005
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In spring, during the active growing season, the oxygen concentration of the sapwood of young olive (Olea europaea L.) trees changed from 80-90 micromol O(2) l(-1) around midday to 20-30 micromol O(2) l(-1) in the night.
Mancuso 2003
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The foliar carbon isotope ratios (delta13C) and gas exchange parameters were measured in order to evaluate the influence of arbuscular mycorrhizal infection on the water use efficiency of two semiarid woodland species including Olea europaea ssp sylvestris.
Querejeta 2003
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It is indicated that in Olea europaea cells sugar levels have a regulatory effect on sugar transport, because the activity for monosaccharide transport was repressed by high sugar concentrations.
Oliveira 2002
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Control analysis, which is a powerful method to quantify the regulation of metabolic pathways have been applied to lipid biosynthesis for the first time by using model tissue culture systems from the important oil crops, Olea europaea and oil palm.
Ramli 2002
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The HPLC phenolic profile of virgin olive oils obtained from young olive trees (Arbequina cv.) grown under different deficit irrigation strategies was studied.
Romero 2002
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The HPLC profiles of phenolic compounds of virgin olive oils obtained from young olive trees (Olea europaea) and the application of a linear irrigation strategy affected these are reported.
Tovar 2001
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Electrical impedance parameters were measured in shoots and leaves of Olea europaea L. for 18 months to determine seasonal variations in intracellular and extracellular resistances and in the state of membranes which were related to rooting ability.
Mancuso 1999
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Phleum pratense and Artemisia vulgaris were the most common pollens in all regions of Turkey, whereas Olea europaea was the most common in Izmir.
Kalyoncu 1995
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[Air pollution effects on the leaf structure of two injury resistant species: Eucalyptus camaldulensis and Olea europaea L.]
Christodoulakis 1991
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| HISTORY OF RECORD |
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| RESEARCHED BY: Michael C. Tims, PhD Candidate February 2005 |
| RESEARCH UPDATED BY: J. Mohanasundaram, MD, PhD January 2008 |
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